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ONTOLOGY REPORT - ANNOTATIONS


Term:p53-dependent G1/S DNA damage checkpoint pathway
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Accession:PW:0000303 term browser browse the term
Definition:The p53-dependent pathway of G1 arrest in response to damaged DNA.
Synonyms:related_synonym: ATM pathway


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altered p53 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ets1 E26 avian leukemia oncogene 1, 5' domain JBrowse link 9 32,636,183 32,757,820 RGD:8663430
G Mdm2 transformed mouse 3T3 cell double minute 2 JBrowse link 10 117,688,875 117,710,758 RGD:2316186
RGD:8663434
G Mdm4 transformed mouse 3T3 cell double minute 4 JBrowse link 1 132,986,105 133,030,587 RGD:8663434
G Mre11a MRE11A homolog A, double strand break repair nuclease JBrowse link 9 14,784,654 14,837,125 RGD:8663431
G Nfya nuclear transcription factor-Y alpha JBrowse link 17 48,386,885 48,409,837 RGD:8663431
RGD:8663430
G Nfyb nuclear transcription factor-Y beta JBrowse link 10 82,748,700 82,764,151 RGD:8663431
RGD:8663430
G Nfyc nuclear transcription factor-Y gamma JBrowse link 4 120,757,435 120,831,579 RGD:8663431
RGD:8663430
G Pin1 protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 JBrowse link 9 20,652,118 20,663,712 RGD:8663430
G Srebf2 sterol regulatory element binding factor 2 JBrowse link 15 82,147,269 82,205,379 RGD:8663431
RGD:8663430
G Trp53 transformation related protein 53 JBrowse link 11 69,580,348 69,591,873 RGD:2316186
RGD:8693397
RGD:8663430
RGD:8663431
RGD:5490966
RGD:5133242
RGD:4143515
G Trp63 transformation related protein 63 JBrowse link 16 25,683,763 25,892,088 RGD:8663431
RGD:8663430
G Trp73 transformation related protein 73 JBrowse link 4 154,056,249 154,139,875 RGD:8663431
RGD:8663430
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor JBrowse link 15 97,854,427 97,908,296 RGD:8663430
p53 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 c-abl oncogene 1, non-receptor tyrosine kinase JBrowse link 2 31,688,244 31,807,093 RGD:6484113
RGD:8662965
G Adgrb1 adhesion G protein-coupled receptor B1 JBrowse link 15 74,516,196 74,589,465 RGD:6907045
G Akt1 thymoma viral proto-oncogene 1 JBrowse link 12 112,653,821 112,674,884 RGD:6484113
G Apaf1 apoptotic peptidase activating factor 1 JBrowse link 10 90,989,311 91,082,743 RGD:6907045
G Atm ataxia telangiectasia mutated JBrowse link 9 53,437,122 53,536,828 RGD:2316155
RGD:6907045
RGD:6484113
RGD:2316156
G Atr ataxia telangiectasia and Rad3 related JBrowse link 9 95,857,597 95,953,217 RGD:6484113
RGD:6907045
G Bax BCL2-associated X protein JBrowse link 7 45,461,695 45,466,903 RGD:6907045
G Bbc3 BCL2 binding component 3 JBrowse link 7 16,308,398 16,318,334 RGD:6907045
G Bid BH3 interacting domain death agonist JBrowse link 6 120,893,119 120,917,062 RGD:6907045
G Brca1 breast cancer 1, early onset JBrowse link 11 101,488,761 101,551,955 RGD:8662965
G Casp3 caspase 3 JBrowse link 8 46,617,291 46,639,698 RGD:6907045
G Casp8 caspase 8 JBrowse link 1 58,795,233 58,847,503 RGD:6907045
G Casp9 caspase 9 JBrowse link 4 141,793,612 141,815,978 RGD:6907045
G Ccna2 cyclin A2 JBrowse link 3 36,564,865 36,573,038 RGD:6484113
G Ccnb1 cyclin B1 JBrowse link 13 100,778,739 100,786,486 RGD:6907045
G Ccnb1-ps cyclin B1, pseudogene JBrowse link 7 42,105,769 42,107,302 RGD:6907045
G Ccnb2 cyclin B2 JBrowse link 9 70,407,689 70,421,554 RGD:6907045
G Ccnb3 cyclin B3 JBrowse link X 6,979,652 7,041,635 RGD:6907045
G Ccnd1 cyclin D1 JBrowse link 7 144,929,931 144,939,937 RGD:6907045
G Ccnd2 cyclin D2 JBrowse link 6 127,125,162 127,152,188 RGD:6907045
G Ccnd3 cyclin D3 JBrowse link 17 47,505,051 47,599,689 RGD:6907045
G Ccne1 cyclin E1 JBrowse link 7 38,097,984 38,107,490 RGD:6907045
G Ccne2 cyclin E2 JBrowse link 4 11,190,433 11,204,779 RGD:6907045
G Ccng1 cyclin G1 JBrowse link 11 40,748,552 40,755,309 RGD:6484113
RGD:6907045
G Ccng2 cyclin G2 JBrowse link 5 93,267,573 93,276,231 RGD:6907045
G Cd82 CD82 antigen JBrowse link 2 93,419,102 93,462,950 RGD:6907045
G Cdk1 cyclin-dependent kinase 1 JBrowse link 10 69,335,146 69,352,912 RGD:6907045
G Cdk2 cyclin-dependent kinase 2 JBrowse link 10 128,697,938 128,705,051 RGD:6907045
G Cdk4 cyclin-dependent kinase 4 JBrowse link 10 127,063,535 127,067,288 RGD:6907045
G Cdk6 cyclin-dependent kinase 6 JBrowse link 5 3,341,004 3,531,008 RGD:6907045
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) JBrowse link 17 29,090,979 29,100,722 RGD:6907045
G Cdkn2a cyclin dependent kinase inhibitor 2A JBrowse link 4 89,274,473 89,294,619 RGD:6907045
G Chek1 checkpoint kinase 1 JBrowse link 9 36,708,482 36,726,658 RGD:2316155
RGD:6907045
RGD:6484113
RGD:2316156
G Chek2 checkpoint kinase 2 JBrowse link 5 110,839,800 110,874,140 RGD:2316155
RGD:6907045
RGD:6484113
RGD:2316156
G Cop1 COP1, E3 ubiquitin ligase JBrowse link 1 159,232,156 159,354,872 RGD:2316155
RGD:6907045
RGD:6484113
G Crebbp CREB binding protein JBrowse link 16 4,081,334 4,213,957 RGD:2316155
RGD:8662965
RGD:6484113
G Cse1l chromosome segregation 1-like (S. cerevisiae) JBrowse link 2 166,906,041 166,946,389 RGD:6484113
G Csnk1a1 casein kinase 1, alpha 1 JBrowse link 18 61,554,236 61,590,320 RGD:6484113
G Csnk1d casein kinase 1, delta JBrowse link 11 120,957,709 120,991,350 RGD:6484113
G Csnk1e casein kinase 1, epsilon JBrowse link 15 79,417,852 79,455,579 RGD:6484113
G Csnk1g1 casein kinase 1, gamma 1 JBrowse link 9 65,908,968 66,045,015 RGD:6484113
G Csnk1g2 casein kinase 1, gamma 2 JBrowse link 10 80,622,676 80,640,771 RGD:6484113
G Csnk1g3 casein kinase 1, gamma 3 JBrowse link 18 53,862,082 53,955,684 RGD:6484113
G Cycs cytochrome c, somatic JBrowse link 6 50,562,563 50,566,569 RGD:6907045
G Cyct cytochrome c, testis JBrowse link 2 76,353,942 76,360,453 RGD:6907045
G Daxx Fas death domain-associated protein JBrowse link 17 33,909,404 33,915,590 RGD:6484113
G Ddb2 damage specific DNA binding protein 2 JBrowse link 2 91,211,545 91,237,132 RGD:6907045
G Dyrk2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 JBrowse link 10 118,855,602 118,889,245 RGD:6484113
G E4f1 E4F transcription factor 1 JBrowse link 17 24,443,778 24,455,392 RGD:6484113
G Ei24 etoposide induced 2.4 mRNA JBrowse link 9 36,779,153 36,797,334 RGD:6907045
G Ep300 E1A binding protein p300 JBrowse link 15 81,586,209 81,652,077 RGD:6484113
G Fas Fas (TNF receptor superfamily member 6) JBrowse link 19 34,290,647 34,327,775 RGD:6907045
G Fbxo11 F-box protein 11 JBrowse link 17 87,990,859 88,066,090 RGD:6484113
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha JBrowse link 6 67,035,096 67,037,407 RGD:6907045
G Gadd45b growth arrest and DNA-damage-inducible 45 beta JBrowse link 10 80,930,091 80,932,204 RGD:6907045
G Gadd45g growth arrest and DNA-damage-inducible 45 gamma JBrowse link 13 51,846,675 51,848,475 RGD:6907045
G Gm10053 predicted gene 10053 JBrowse link 19 24,875,626 24,876,875 RGD:6907045
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 16 38,089,001 38,246,084 RGD:6484113
G Gtse1 G two S phase expressed protein 1 JBrowse link 15 85,859,691 85,876,573 RGD:6907045
G Hdac1 histone deacetylase 1 JBrowse link 4 129,516,104 129,542,646 RGD:2316155
G Hipk2 homeodomain interacting protein kinase 2 JBrowse link 6 38,687,512 38,876,331 RGD:6484113
G Huwe1 HECT, UBA and WWE domain containing 1 JBrowse link X 151,800,785 151,935,417 RGD:6484113
G Igf1 insulin-like growth factor 1 JBrowse link 10 87,858,265 87,937,047 RGD:6907045
G Igfbp3 insulin-like growth factor binding protein 3 JBrowse link 11 7,206,086 7,215,498 RGD:6907045
G Kat2a K(lysine) acetyltransferase 2A JBrowse link 11 100,704,746 100,712,485 RGD:8662965
G Kat2b K(lysine) acetyltransferase 2B JBrowse link 17 53,566,774 53,672,721 RGD:6484113
RGD:8662965
G Kat5 K(lysine) acetyltransferase 5 JBrowse link 19 5,603,014 5,611,556 RGD:2316155
RGD:8662965
RGD:6484113
G Kat8 K(lysine) acetyltransferase 8 JBrowse link 7 127,912,517 127,925,838 RGD:2316155
RGD:6484113
G Kmt5a lysine methyltransferase 5A JBrowse link 5 124,439,930 124,462,311 RGD:6484113
G Mapk14 mitogen-activated protein kinase 14 JBrowse link 17 28,691,342 28,748,405 RGD:6484113
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 14 33,377,898 33,447,353 RGD:6484113
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 11 49,846,728 49,886,421 RGD:6484113
G Mdm2 transformed mouse 3T3 cell double minute 2 JBrowse link 10 117,688,875 117,710,758 RGD:2316155
RGD:6907045
RGD:6484113
RGD:2316156
G Mdm4 transformed mouse 3T3 cell double minute 4 JBrowse link 1 132,986,105 133,030,587 RGD:2316155
RGD:6907045
RGD:6484113
RGD:2316156
G Muc1 mucin 1, transmembrane JBrowse link 3 89,229,056 89,233,381 RGD:8662965
G Nedd8 neural precursor cell expressed, developmentally down-regulated gene 8 JBrowse link 14 55,662,263 55,671,880 RGD:6484113
G Perp PERP, TP53 apoptosis effector JBrowse link 10 18,845,071 18,857,073 RGD:6907045
G Pidd1 p53 induced death domain protein 1 JBrowse link 7 141,438,113 141,447,565 RGD:6907045
G Pin1 protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 JBrowse link 9 20,652,118 20,663,712 RGD:6484113
RGD:8662965
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 66,458,604 66,465,558 RGD:6907045
G Pou4f1 POU domain, class 4, transcription factor 1 JBrowse link 14 104,461,675 104,468,118 RGD:8662965
G Pou4f2 POU domain, class 4, transcription factor 2 JBrowse link 8 78,433,009 78,436,647 RGD:8662965
G Ppm1d protein phosphatase 1D magnesium-dependent, delta isoform JBrowse link 11 85,311,254 85,347,071 RGD:6484113
RGD:6907045
G Ppp1r13b protein phosphatase 1, regulatory subunit 13B JBrowse link 12 111,828,457 111,908,119 RGD:8662965
G Ppp1r13l protein phosphatase 1, regulatory subunit 13 like JBrowse link 7 19,359,724 19,378,540 RGD:6484113
RGD:8662965
G Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform JBrowse link 11 52,098,824 52,122,749 RGD:6484113
G Prkcd protein kinase C, delta JBrowse link 14 30,595,353 30,626,414 RGD:6484113
G Prmt5 protein arginine N-methyltransferase 5 JBrowse link 14 54,507,182 54,517,470 RGD:6484113
G Pten phosphatase and tensin homolog JBrowse link 19 32,757,577 32,826,160 RGD:6907045
G Ptpa protein phosphatase 2 protein activator JBrowse link 2 30,416,050 30,447,807 RGD:6484113
G Rassf1 Ras association (RalGDS/AF-6) domain family member 1 JBrowse link 9 107,551,434 107,562,267 RGD:6484113
G Rchy1 ring finger and CHY zinc finger domain containing 1 JBrowse link 5 91,948,842 91,963,145 RGD:2316155
RGD:6907045
RGD:6484113
G Rpl11 ribosomal protein L11 JBrowse link 4 136,049,354 136,053,393 RGD:6484113
G Rpl23 ribosomal protein L23 JBrowse link 11 97,777,526 97,782,439 RGD:6484113
G Rpl5 ribosomal protein L5 JBrowse link 5 107,900,508 107,909,005 RGD:6484113
G Rprm reprimo, TP53 dependent G2 arrest mediator candidate JBrowse link 2 54,084,093 54,085,552 RGD:6907045
G Rrm2 ribonucleotide reductase M2 JBrowse link 12 24,708,254 24,714,146 RGD:6907045
G Rrm2b ribonucleotide reductase M2 B (TP53 inducible) JBrowse link 15 37,923,952 37,961,119 RGD:6907045
G Serpinb5 serine (or cysteine) peptidase inhibitor, clade B, member 5 JBrowse link 1 106,861,175 106,883,348 RGD:6907045
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 JBrowse link 5 137,061,504 137,072,272 RGD:6907045
G Sesn1 sestrin 1 JBrowse link 10 41,810,574 41,908,436 RGD:6907045
G Sesn2 sestrin 2 JBrowse link 4 132,492,804 132,510,456 RGD:6907045
G Sesn3 sestrin 3 JBrowse link 9 14,276,301 14,326,134 RGD:6907045
G Setd7 SET domain containing (lysine methyltransferase) 7 JBrowse link 3 51,515,318 51,560,823 RGD:2316155
RGD:6484113
G Sfn stratifin JBrowse link 4 133,600,556 133,602,168 RGD:6907045
G Shisa5 shisa family member 5 JBrowse link 9 109,038,567 109,057,792 RGD:6907045
G Siah1a siah E3 ubiquitin protein ligase 1A JBrowse link 8 86,720,454 86,746,006 RGD:6907045
G Siah1b siah E3 ubiquitin protein ligase 1B JBrowse link X 164,070,703 164,076,493 RGD:6907045
G Sirt1 sirtuin 1 JBrowse link 10 63,319,005 63,339,035 RGD:2316155
G Skp2 S-phase kinase-associated protein 2 (p45) JBrowse link 15 9,111,982 9,155,425 RGD:6484113
G Smyd2 SET and MYND domain containing 2 JBrowse link 1 189,880,492 189,922,495 RGD:2316155
RGD:6484113
G Steap3 STEAP family member 3 JBrowse link 1 120,226,414 120,271,082 RGD:6907045
G Thbs1 thrombospondin 1 JBrowse link 2 118,111,876 118,127,133 RGD:6907045
G Trim28 tripartite motif-containing 28 JBrowse link 7 13,024,152 13,031,032 RGD:6484113
G Trp53 transformation related protein 53 JBrowse link 11 69,580,348 69,591,873 RGD:2316155
RGD:6907045
RGD:6484113
RGD:2316156
G Trp53bp2 transformation related protein 53 binding protein 2 JBrowse link 1 182,409,167 182,462,436 RGD:8662965
G Trp73 transformation related protein 73 JBrowse link 4 154,056,249 154,139,875 RGD:6907045
G Tsc2 TSC complex subunit 2 JBrowse link 17 24,595,816 24,632,676 RGD:6907045
G Ttc5 tetratricopeptide repeat domain 5 JBrowse link 14 50,765,409 50,785,520 RGD:6484113
G Ube2d1 ubiquitin-conjugating enzyme E2D 1 JBrowse link 10 71,254,980 71,285,384 RGD:6484113
G Usp7 ubiquitin specific peptidase 7 JBrowse link 16 8,688,722 8,757,067 RGD:2316155
RGD:6484113
G Ybx1 Y box protein 1 JBrowse link 4 119,277,327 119,296,265 RGD:8662965
G Yy1 YY1 transcription factor JBrowse link 12 108,792,945 108,820,148 RGD:6484113
G Zfp385a zinc finger protein 385A JBrowse link 15 103,313,895 103,340,086 RGD:8662965
G Zfp420 zinc finger protein 420 JBrowse link 7 29,859,967 29,877,302 RGD:8662965
G Zmat3 zinc finger matrin type 3 JBrowse link 3 32,334,792 32,365,665 RGD:6907045
G Znhit1 zinc finger, HIT domain containing 1 JBrowse link 5 136,982,194 136,987,959 RGD:8662965

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6011
    regulatory pathway 3631
      pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis 1647
        cell cycle pathway 229
          cell cycle checkpoint pathway 136
            G1/S DNA damage checkpoint pathway 135
              p53-dependent G1/S DNA damage checkpoint pathway 135
                p53 signaling pathway + 135
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.