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ONTOLOGY REPORT - ANNOTATIONS


Term:p53-dependent G1/S DNA damage checkpoint pathway
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Accession:PW:0000303 term browser browse the term
Definition:The p53-dependent pathway of G1 arrest in response to damaged DNA.
Synonyms:related_synonym: ATM pathway


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p53-dependent G1/S DNA damage checkpoint pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CCNE1 cyclin E1 JBrowse link 6 39,919,541 39,933,224 RGD:9068941
G TP53 tumor protein p53 JBrowse link 12 52,939,643 52,953,786 RGD:9068941
altered p53 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ETS1 ETS proto-oncogene 1, transcription factor JBrowse link 9 55,377,264 55,512,180 RGD:9068941
G MDM2 MDM2 proto-oncogene JBrowse link 5 33,105,717 33,137,602 RGD:9068941
G MDM4 MDM4 regulator of p53 JBrowse link 9 65,175,488 65,219,747 RGD:9068941
G MRE11 MRE11 homolog, double strand break repair nuclease JBrowse link 9 26,572,352 26,634,596 RGD:9068941
G NFYA nuclear transcription factor Y subunit alpha JBrowse link 7 36,385,677 36,409,495 RGD:9068941
G NFYB nuclear transcription factor Y subunit beta JBrowse link 5 80,333,762 80,353,466 RGD:9068941
G NFYC nuclear transcription factor Y subunit gamma JBrowse link 6 170,413,631 170,486,012 RGD:9068941
G PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 JBrowse link 2 68,715,898 68,729,471 RGD:9068941
G SREBF2 sterol regulatory element binding transcription factor 2 JBrowse link 5 6,719,484 6,784,724 RGD:9068941
G TP53 tumor protein p53 JBrowse link 12 52,939,643 52,953,786 RGD:9068941
G TP63 tumor protein p63 JBrowse link 13 127,115,990 127,347,082 RGD:9068941
G TP73 tumor protein p73 JBrowse link 6 65,169,770 65,228,997 RGD:9068941
G VDR vitamin D receptor JBrowse link 5 78,205,807 78,266,505 RGD:9068941
p53 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 1 270,761,641 270,906,708 RGD:9068941
G ADGRB1 adhesion G protein-coupled receptor B1 JBrowse link 4 1,582,321 1,658,639 RGD:9068941
G AKT1 AKT serine/threonine kinase 1 RGD:9068941
G APAF1 apoptotic peptidase activating factor 1 JBrowse link 5 85,166,616 85,258,751 RGD:9068941
G ATM ATM serine/threonine kinase JBrowse link 9 36,620,656 36,759,555 RGD:9068941
G ATR ATR serine/threonine kinase JBrowse link 13 83,175,515 83,289,986 RGD:9068941
G BAX BCL2 associated X, apoptosis regulator JBrowse link 6 54,222,341 54,228,150 RGD:9068941
G BBC3 BCL2 binding component 3 JBrowse link 6 53,037,103 53,046,902 RGD:9068941
G BID BH3 interacting domain death agonist JBrowse link 5 69,849,007 69,874,647 RGD:9068941
G BRCA1 BRCA1 DNA repair associated JBrowse link 12 19,788,087 19,854,515 RGD:9068941
G CASP3 caspase 3 JBrowse link 15 45,744,320 45,753,252 RGD:9068941
G CASP8 caspase 8 JBrowse link 15 104,923,659 104,948,470 RGD:9068941
G CASP9 caspase 9 JBrowse link 6 74,707,597 74,730,033 RGD:9068941
G CCNA2 cyclin A2 JBrowse link 8 102,260,346 102,266,274 RGD:9068941
G CCNB1 cyclin B1 JBrowse link 16 47,338,239 47,348,385 RGD:9068941
G CCNB2 cyclin B2 JBrowse link 1 112,907,047 112,942,218 RGD:9068941
G CCNB3 cyclin B3 JBrowse link X 43,922,729 43,988,939 RGD:9068941
G CCND1 cyclin D1 JBrowse link 2 3,621,242 3,633,380 RGD:9068941
G CCND2 cyclin D2 JBrowse link 5 66,092,483 66,114,575 RGD:9068941
G CCND3 cyclin D3 JBrowse link 7 37,087,336 37,182,462 RGD:9068941
G CCNE1 cyclin E1 JBrowse link 6 39,919,541 39,933,224 RGD:9068941
G CCNE2 cyclin E2 JBrowse link 4 41,802,090 41,821,870 RGD:9068941
G CCNG1 cyclin G1 JBrowse link 16 60,349,255 60,356,737 RGD:9068941
G CCNG2 cyclin G2 JBrowse link 8 72,790,394 72,800,553 RGD:9068941
G CD82 CD82 molecule JBrowse link 2 17,751,153 17,803,172 RGD:9068941
G CDK1 cyclin dependent kinase 1 JBrowse link 14 64,233,945 64,255,290 RGD:9068941
G CDK2 cyclin dependent kinase 2 JBrowse link 5 21,365,723 21,372,170 RGD:9068941
G CDK4 cyclin dependent kinase 4 JBrowse link 5 23,039,206 23,041,959 RGD:9068941
G CDK6 cyclin dependent kinase 6 JBrowse link 9 72,510,858 72,765,631 RGD:9068941
G CDKN1A cyclin dependent kinase inhibitor 1A JBrowse link 7 32,354,776 32,363,771 RGD:9068941
G CHEK1 checkpoint kinase 1 JBrowse link 9 52,759,224 52,790,878 RGD:9068941
G CHEK2 checkpoint kinase 2 JBrowse link 14 45,699,833 45,967,350 RGD:9068941
G COP1 COP1 E3 ubiquitin ligase JBrowse link 9 117,913,504 118,114,268 RGD:9068941
G CREBBP CREB binding protein JBrowse link 3 38,388,366 38,530,243 RGD:9068941
G CSE1L chromosome segregation 1 like JBrowse link 17 50,744,896 50,796,835 RGD:9068941
G CSNK1A1 casein kinase 1 alpha 1 JBrowse link 2 150,612,845 150,662,431 RGD:9068941
G CSNK1D casein kinase 1 delta JBrowse link 12 768,856 794,495 RGD:9068941
G CSNK1G1 casein kinase 1 gamma 1 JBrowse link 1 107,690,049 107,884,054 RGD:9068941
G CSNK1G2 casein kinase 1 gamma 2 JBrowse link 2 76,573,979 76,609,631 RGD:9068941
G CSNK1G3 casein kinase 1 gamma 3 JBrowse link 2 127,013,736 127,129,547 RGD:9068941
G CYCS cytochrome c, somatic JBrowse link 18 47,169,921 47,172,212 RGD:9068941
G DAXX death domain associated protein JBrowse link 7 29,676,854 29,681,145 RGD:9068941
G DDB2 damage specific DNA binding protein 2 JBrowse link 2 15,342,614 15,370,623 RGD:9068941
G DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 JBrowse link 5 32,047,614 32,064,231 RGD:9068941
G E4F1 E4F transcription factor 1 JBrowse link 3 39,757,679 39,773,024 RGD:9068941
G EI24 EI24 autophagy associated transmembrane protein JBrowse link 9 52,704,560 52,724,966 RGD:9068941
G EP300 E1A binding protein p300 JBrowse link 5 7,311,165 7,394,515 RGD:9068941
G FAS Fas cell surface death receptor JBrowse link 14 100,927,305 100,954,781 RGD:9068941
G FBXO11 F-box protein 11 JBrowse link 3 92,696,402 92,792,623 RGD:9068941
G GADD45A growth arrest and DNA damage inducible alpha JBrowse link 6 144,940,702 144,944,089 RGD:9068941
G GADD45B growth arrest and DNA damage inducible beta JBrowse link 2 76,107,928 76,111,458 RGD:9068941
G GADD45G growth arrest and DNA damage inducible gamma JBrowse link 14 1,166,000 1,167,538 RGD:9068941
G GSK3B glycogen synthase kinase 3 beta JBrowse link 13 140,136,109 140,370,197 RGD:9068941
G GTSE1 G2 and S-phase expressed 1 JBrowse link 5 3,227,813 3,246,679 RGD:9068941
G HDAC1 histone deacetylase 1 JBrowse link 6 88,749,611 88,785,220 RGD:9068941
G HIPK2 homeodomain interacting protein kinase 2 JBrowse link 18 9,940,535 10,141,815 RGD:9068941
G HUWE1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 JBrowse link X 46,281,958 46,444,315 RGD:9068941
G IGF1 insulin like growth factor 1 JBrowse link 5 81,762,027 81,909,253 RGD:9068941
G IGFBP3 insulin like growth factor binding protein 3 JBrowse link 18 50,002,921 50,009,425 RGD:9068941
G KAT2A lysine acetyltransferase 2A JBrowse link 12 20,638,493 20,647,464 RGD:9068941
G KAT2B lysine acetyltransferase 2B JBrowse link 13 6,985,151 7,099,771 RGD:9068941
G KAT5 lysine acetyltransferase 5 JBrowse link 2 6,560,544 6,572,461 RGD:9068941
G KAT8 lysine acetyltransferase 8 JBrowse link 3 17,362,326 17,373,110 RGD:9068941
G KMT5A lysine methyltransferase 5A JBrowse link 14 29,523,102 29,543,522 RGD:9068941
G LOC100523244 casein kinase I JBrowse link 5 9,594,461 9,620,483 RGD:9068941
G LOC102164547 zinc finger protein 420 JBrowse link 6 46,479,566 46,530,528 RGD:9068941
G MAPK14 mitogen-activated protein kinase 14 JBrowse link 7 31,791,398 31,861,544 RGD:9068941
G MAPK8 mitogen-activated protein kinase 8 JBrowse link 14 88,988,914 89,108,875 RGD:9068941
G MAPK9 mitogen-activated protein kinase 9 JBrowse link 2 78,338,466 78,399,108 RGD:9068941
G MDM2 MDM2 proto-oncogene JBrowse link 5 33,105,717 33,137,602 RGD:9068941
G MDM4 MDM4 regulator of p53 JBrowse link 9 65,175,488 65,219,747 RGD:9068941
G MUC1 mucin 1, cell surface associated JBrowse link 4 94,626,317 94,631,194 RGD:9068941
G NEDD8 NEDD8 ubiquitin like modifier JBrowse link 7 75,069,947 75,085,905 RGD:9068941
G P14ARF p14ARF protein JBrowse link 1 200,774,496 200,799,149 RGD:9068941
G PERP p53 apoptosis effector related to PMP22 JBrowse link 1 26,301,254 26,317,046 RGD:9068941
G PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 JBrowse link 2 68,715,898 68,729,471 RGD:9068941
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 1 161,184,458 161,188,138 RGD:9068941
G POU4F1 POU class 4 homeobox 1 JBrowse link 11 50,729,746 50,732,626 RGD:9068941
G POU4F2 POU class 4 homeobox 2 JBrowse link 8 82,044,443 82,046,377 RGD:9068941
G PPM1D protein phosphatase, Mg2+/Mn2+ dependent 1D JBrowse link 12 37,485,601 37,536,159 RGD:9068941
G PPP1R13B protein phosphatase 1 regulatory subunit 13B RGD:9068941
G PPP1R13L protein phosphatase 1 regulatory subunit 13 like JBrowse link 6 51,763,214 51,779,902 RGD:9068941
G PPP2CA protein phosphatase 2 catalytic subunit alpha JBrowse link 2 136,497,780 136,522,630 RGD:9068941
G PRKCD protein kinase C delta JBrowse link 13 35,290,835 35,323,245 RGD:9068941
G PRMT5 protein arginine methyltransferase 5 JBrowse link 7 76,110,956 76,119,619 RGD:9068941
G PTEN phosphatase and tensin homolog JBrowse link 14 99,929,590 100,021,619 RGD:9068941
G PTPA protein phosphatase 2 phosphatase activator JBrowse link 1 269,401,776 269,431,465 RGD:9068941
G RASSF1 Ras association domain family member 1 JBrowse link 13 32,816,156 32,825,486 RGD:9068941
G RCHY1 ring finger and CHY zinc finger domain containing 1 JBrowse link 8 71,155,388 71,182,020 RGD:9068941
G RPL11 ribosomal protein L11 JBrowse link 6 81,523,510 81,526,925 RGD:9068941
G RPL23 ribosomal protein L23 JBrowse link 12 23,279,965 23,285,538 RGD:9068941
G RPL5 ribosomal protein L5 JBrowse link 4 124,359,786 124,367,612 RGD:9068941
G RPRM reprimo, TP53 dependent G2 arrest mediator homolog JBrowse link 15 61,140,687 61,143,397 RGD:9068941
G RRM2 ribonucleotide reductase regulatory subunit M2 JBrowse link 3 126,357,198 126,367,145 RGD:9068941
G RRM2B ribonucleotide reductase regulatory TP53 inducible subunit M2B JBrowse link 4 34,823,869 34,859,777 RGD:9068941
G SERPINB5 serpin family B member 5 JBrowse link 1 158,167,756 158,195,896 RGD:9068941
G SERPINE1 serpin family E member 1 JBrowse link 3 8,863,738 8,871,572 RGD:9068941
G SESN1 sestrin 1 JBrowse link 1 75,056,731 75,170,374 RGD:9068941
G SESN2 sestrin 2 JBrowse link 6 85,321,982 85,348,044 RGD:9068941
G SESN3 sestrin 3 JBrowse link 9 27,207,239 27,279,205 RGD:9068941
G SETD7 SET domain containing 7, histone lysine methyltransferase JBrowse link 8 87,478,266 87,527,190 RGD:9068941
G SHISA5 shisa family member 5 JBrowse link 13 31,180,844 31,205,724 RGD:9068941
G SIAH1 siah E3 ubiquitin protein ligase 1 JBrowse link 6 36,337,770 36,365,784 RGD:9068941
G SIRT1 sirtuin 1 JBrowse link 14 71,091,167 71,126,351 RGD:9068941
G SKP2 S-phase kinase associated protein 2 JBrowse link 16 21,463,270 21,500,925 RGD:9068941
G SMYD2 SET and MYND domain containing 2 JBrowse link 9 129,263,524 129,316,226 RGD:9068941
G STEAP3 STEAP3 metalloreductase JBrowse link 15 24,736,556 24,785,376 RGD:9068941
G THBS1 thrombospondin 1 JBrowse link 1 131,728,781 131,746,098 RGD:9068941
G TP53 tumor protein p53 JBrowse link 12 52,939,643 52,953,786 RGD:9068941
G TP53BP2 tumor protein p53 binding protein 2 JBrowse link 10 19,823,932 19,889,883 RGD:9068941
G TP53I3 tumor protein p53 inducible protein 3 JBrowse link 3 114,599,285 114,605,455 RGD:9068941
G TP73 tumor protein p73 JBrowse link 6 65,169,770 65,228,997 RGD:9068941
G TRIM28 tripartite motif containing 28 JBrowse link 6 63,094,382 63,101,532 RGD:9068941
G TSC2 TSC complex subunit 2 JBrowse link 3 39,898,924 39,935,579 RGD:9068941
G TTC5 tetratricopeptide repeat domain 5 JBrowse link 7 78,578,247 78,600,794 RGD:9068941
G UBE2D1 ubiquitin conjugating enzyme E2 D1 JBrowse link 14 92,296,314 92,330,432 RGD:9068941
G USP7 ubiquitin specific peptidase 7 JBrowse link 3 33,754,357 33,810,480 RGD:9068941
G YBX1 Y-box binding protein 1 JBrowse link 6 168,716,782 168,736,475 RGD:9068941
G YY1 YY1 transcription factor JBrowse link 7 121,132,168 121,170,699 RGD:9068941
G ZMAT3 zinc finger matrin-type 3 JBrowse link 13 117,113,272 117,147,639 RGD:9068941
G ZNF385A zinc finger protein 385A JBrowse link 5 19,560,317 19,583,254 RGD:9068941
G ZNHIT1 zinc finger HIT-type containing 1 JBrowse link 3 8,918,873 8,926,595 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5635
    regulatory pathway 3440
      pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis 1607
        cell cycle pathway 224
          cell cycle checkpoint pathway 131
            G1/S DNA damage checkpoint pathway 130
              p53-dependent G1/S DNA damage checkpoint pathway 130
                p53 signaling pathway + 130
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.