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Term:p53-dependent G1/S DNA damage checkpoint pathway
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Accession:PW:0000303 term browser browse the term
Definition:The p53-dependent pathway of G1 arrest in response to damaged DNA.
Synonyms:related_synonym: ATM pathway


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p53-dependent G1/S DNA damage checkpoint pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccne1 cyclin E1 JBrowse link NW_004936570 5,536,817 5,547,880 RGD:9068941
G Tp53 tumor protein p53 JBrowse link NW_004936595 919,807 935,367 RGD:9068941
altered p53 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ets1 ETS proto-oncogene 1, transcription factor JBrowse link NW_004936572 3,728,971 3,795,612 RGD:9068941
G Mdm2 MDM2 proto-oncogene JBrowse link NW_004936545 6,709,903 6,732,334 RGD:9068941
G Mdm4 MDM4 regulator of p53 JBrowse link NW_004936567 268,151 299,494 RGD:9068941
G Mre11 MRE11 homolog, double strand break repair nuclease JBrowse link NW_004936674 466,495 528,072 RGD:9068941
G Nfya nuclear transcription factor Y subunit alpha JBrowse link NW_004936476 18,728,575 18,750,917 RGD:9068941
G Nfyb nuclear transcription factor Y subunit beta JBrowse link NW_004936492 10,359,387 10,377,537 RGD:9068941
G Nfyc nuclear transcription factor Y subunit gamma JBrowse link NW_004936474 22,368,279 22,432,671 RGD:9068941
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 JBrowse link NW_004936659 309,530 321,294 RGD:9068941
G Srebf2 sterol regulatory element binding transcription factor 2 JBrowse link NW_004936492 115,923 174,614 RGD:9068941
G Tp53 tumor protein p53 JBrowse link NW_004936595 919,807 935,367 RGD:9068941
G Tp63 tumor protein p63 JBrowse link NW_004936578 492,267 705,282 RGD:9068941
G Tp73 tumor protein p73 JBrowse link NW_004936737 171,894 211,464 RGD:9068941
G Vdr vitamin D receptor JBrowse link NW_004936512 5,741,836 5,800,999 RGD:9068941
p53 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link NW_004936487 17,690,206 17,819,619 RGD:9068941
G Adgrb1 adhesion G protein-coupled receptor B1 JBrowse link NW_004936470 9,247,749 9,313,230 RGD:9068941
G Akt1 AKT serine/threonine kinase 1 JBrowse link NW_004936621 620,163 639,115 RGD:9068941
G Apaf1 apoptotic peptidase activating factor 1 JBrowse link NW_004936492 14,818,561 14,902,231 RGD:9068941
G Atm ATM serine/threonine kinase JBrowse link NW_004936551 359,134 534,672 RGD:9068941
G Atr ATR serine/threonine kinase JBrowse link NW_004936540 4,074,543 4,178,859 RGD:9068941
G Bax BCL2 associated X, apoptosis regulator JBrowse link NW_004936664 2,968,103 2,973,652 RGD:9068941
G Bbc3 BCL2 binding component 3 JBrowse link NW_004936664 962,115 966,797 RGD:9068941
G Bid BH3 interacting domain death agonist JBrowse link NW_004936807 708,340 750,127 RGD:9068941
G Brca1 BRCA1 DNA repair associated JBrowse link NW_004936490 17,735,444 17,801,456 RGD:9068941
G Casp3 caspase 3 JBrowse link NW_004936554 4,571,072 4,593,765 RGD:9068941
G Casp8 caspase 8 JBrowse link NW_004936726 554,627 596,334 RGD:9068941
G Casp9 caspase 9 JBrowse link NW_004936474 3,178,097 3,196,130 RGD:9068941
G Ccna2 cyclin A2 JBrowse link NW_004936662 1,073,460 1,079,136 RGD:9068941
G Ccnb1 cyclin B1 JBrowse link NW_004936480 400,287 407,677 RGD:9068941
G Ccnb2 cyclin B2 JBrowse link NW_004936471 20,216,435 20,238,543 RGD:9068941
G Ccnb3 cyclin B3 JBrowse link NW_004936721 1,729,979 1,782,399 RGD:9068941
G Ccnd2 cyclin D2 JBrowse link NW_004936606 4,474,801 4,496,158 RGD:9068941
G Ccnd3 cyclin D3 JBrowse link NW_004936476 17,799,754 17,886,835 RGD:9068941
G Ccne1 cyclin E1 JBrowse link NW_004936570 5,536,817 5,547,880 RGD:9068941
G Ccne2 cyclin E2 JBrowse link NW_004936544 7,839,730 7,852,251 RGD:9068941
G Ccng1 cyclin G1 JBrowse link NW_004936515 614,287 621,213 RGD:9068941
G Ccng2 cyclin G2 JBrowse link NW_004936676 1,026,113 1,035,313 RGD:9068941
G Cdk1 cyclin dependent kinase 1 JBrowse link NW_004936614 2,300,682 2,313,611 RGD:9068941
G Cdk2 cyclin dependent kinase 2 JBrowse link NW_004936646 379,849 385,648 RGD:9068941
G Cdk4 cyclin dependent kinase 4 JBrowse link NW_004936646 1,886,262 1,889,260 RGD:9068941
G Cdk6 cyclin dependent kinase 6 JBrowse link NW_004936803 1,025,047 1,229,396 RGD:9068941
G Cdkn1a cyclin dependent kinase inhibitor 1A JBrowse link NW_004936476 22,717,308 22,725,127 RGD:9068941
G Chek1 checkpoint kinase 1 JBrowse link NW_004936743 2,004,535 2,027,287 RGD:9068941
G Chek2 checkpoint kinase 2 JBrowse link NW_004936657 2,805,947 2,848,180 RGD:9068941
G Cop1 COP1 E3 ubiquitin ligase JBrowse link NW_004936481 12,262,415 12,437,627 RGD:9068941
G Crebbp CREB binding protein JBrowse link NW_004936694 552,447 663,237 RGD:9068941
G Cse1l chromosome segregation 1 like JBrowse link NW_004936514 5,112,961 5,157,584 RGD:9068941
G Csnk1a1 casein kinase 1 alpha 1 JBrowse link NW_004936504 5,351,354 5,394,856 RGD:9068941
G Csnk1d casein kinase 1 delta JBrowse link NW_004936594 5,720,887 5,743,206 RGD:9068941
G Csnk1g1 casein kinase 1 gamma 1 JBrowse link NW_004936471 24,642,337 24,795,633 RGD:9068941
G Csnk1g2 casein kinase 1 gamma 2 JBrowse link NW_004936588 1,140,332 1,148,265 RGD:9068941
G Csnk1g3 casein kinase 1 gamma 3 JBrowse link NW_004936575 3,858,996 3,965,758 RGD:9068941
G Daxx death domain associated protein JBrowse link NW_004936476 25,546,091 25,550,390 RGD:9068941
G Ddb2 damage specific DNA binding protein 2 JBrowse link NW_004936562 1,960,406 1,974,809 RGD:9068941
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 JBrowse link NW_004936545 5,542,873 5,555,469 RGD:9068941
G E4f1 E4F transcription factor 1 JBrowse link NW_004936694 1,811,131 1,829,193 RGD:9068941
G Ei24 EI24 autophagy associated transmembrane protein JBrowse link NW_004936743 1,957,948 1,970,885 RGD:9068941
G Ep300 E1A binding protein p300 JBrowse link NW_004936492 696,982 778,132 RGD:9068941
G Fas Fas cell surface death receptor JBrowse link NW_004936735 209,369 234,582 RGD:9068941
G Fbxo11 F-box protein 11 JBrowse link NW_004936508 4,622,695 4,708,694 RGD:9068941
G Gadd45a growth arrest and DNA damage inducible alpha JBrowse link NW_004936591 3,998,359 4,001,491 RGD:9068941
G Gadd45b growth arrest and DNA damage inducible beta JBrowse link NW_004936588 1,476,580 1,479,444 RGD:9068941
G Gadd45g growth arrest and DNA damage inducible gamma JBrowse link NW_004936780 501,452 503,272 RGD:9068941
G Gsk3b glycogen synthase kinase 3 beta JBrowse link NW_004936536 6,730,070 6,893,818 RGD:9068941
G Gtse1 G2 and S-phase expressed 1 JBrowse link NW_004936629 3,590,101 3,607,625 RGD:9068941
G Hdac1 histone deacetylase 1 JBrowse link NW_004936474 15,320,635 15,351,418 RGD:9068941
G Hipk2 homeodomain interacting protein kinase 2 JBrowse link NW_004936592 3,800,619 3,934,347 RGD:9068941
G Huwe1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 JBrowse link NW_004936751 478,978 622,818 RGD:9068941
G Igf1 insulin like growth factor 1 JBrowse link NW_004936492 11,709,623 11,784,028 RGD:9068941
G Igfbp3 insulin like growth factor binding protein 3 JBrowse link NW_004936478 20,511,490 20,518,251 RGD:9068941
G Kat2a lysine acetyltransferase 2A JBrowse link NW_004936490 16,952,698 16,960,424 RGD:9068941
G Kat2b lysine acetyltransferase 2B JBrowse link NW_004936473 12,341,545 12,415,637 RGD:9068941
G Kat5 lysine acetyltransferase 5 JBrowse link NW_004936599 3,767,526 3,775,416 RGD:9068941
G Kat8 lysine acetyltransferase 8 JBrowse link NW_004936501 13,475,676 13,487,617 RGD:9068941
G Kmt5a lysine methyltransferase 5A JBrowse link NW_004936558 1,346,040 1,366,601 RGD:9068941
G Mapk14 mitogen-activated protein kinase 14 JBrowse link NW_004936476 23,237,762 23,310,211 RGD:9068941
G Mapk8 mitogen-activated protein kinase 8 JBrowse link NW_004936728 1,775,746 1,893,895 RGD:9068941
G Mapk9 mitogen-activated protein kinase 9 JBrowse link NW_004936739 551,678 602,027 RGD:9068941
G Mdm2 MDM2 proto-oncogene JBrowse link NW_004936545 6,709,903 6,732,334 RGD:9068941
G Mdm4 MDM4 regulator of p53 JBrowse link NW_004936567 268,151 299,494 RGD:9068941
G Muc1 mucin 1, cell surface associated JBrowse link NW_004936580 4,691,870 4,694,092 RGD:9068941
G Nedd8 NEDD8 ubiquitin like modifier JBrowse link NW_004936722 331,116 338,496 RGD:9068941
G Perp p53 apoptosis effector related to PMP22 JBrowse link NW_004936560 5,285,071 5,301,253 RGD:9068941
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 JBrowse link NW_004936659 309,530 321,294 RGD:9068941
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link NW_004936497 4,985,995 4,986,720 RGD:9068941
G Pou4f1 POU class 4 homeobox 1 JBrowse link NW_004936511 2,857,017 2,859,705 RGD:9068941
G Pou4f2 POU class 4 homeobox 2 JBrowse link NW_004936535 2,705,184 2,711,785 RGD:9068941
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent 1D JBrowse link NW_004936490 2,139,201 2,183,850 RGD:9068941
G Ppp1r13b protein phosphatase 1 regulatory subunit 13B JBrowse link NW_004936621 1,383,137 1,447,376 RGD:9068941
G Ppp1r13l protein phosphatase 1 regulatory subunit 13 like JBrowse link NW_004936706 1,835,306 1,846,821 RGD:9068941
G Ppp2ca protein phosphatase 2 catalytic subunit alpha JBrowse link NW_004936647 1,031,118 1,055,961 RGD:9068941
G Prkcd protein kinase C delta JBrowse link NW_004936473 3,892,625 3,923,467 RGD:9068941
G Prmt5 protein arginine methyltransferase 5 JBrowse link NW_004936722 1,379,515 1,388,538 RGD:9068941
G Pten phosphatase and tensin homolog JBrowse link NW_004936735 1,252,414 1,338,318 RGD:9068941
G Ptpa protein phosphatase 2 phosphatase activator JBrowse link NW_004936487 16,536,740 16,564,087 RGD:9068941
G Rassf1 Ras association domain family member 1 JBrowse link NW_004936529 1,857,177 1,866,198 RGD:9068941
G Rchy1 ring finger and CHY zinc finger domain containing 1 JBrowse link NW_004936598 436,559 453,137 RGD:9068941
G Rpl11 ribosomal protein L11 JBrowse link NW_004936474 8,855,782 8,858,287 RGD:9068941
G Rpl23 ribosomal protein L23 JBrowse link NW_004936490 14,240,635 14,245,194 RGD:9068941
G Rpl5 ribosomal protein L5 JBrowse link NW_004936537 6,341,961 6,344,831 RGD:9068941
G Rprm reprimo, TP53 dependent G2 arrest mediator homolog JBrowse link NW_004936469 24,313,850 24,315,318 RGD:9068941
G Rrm2 ribonucleotide reductase regulatory subunit M2 JBrowse link NW_004936532 6,348,041 6,390,144 RGD:9068941
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B JBrowse link NW_004936470 41,354,387 41,401,308 RGD:9068941
G Serpinb5 serpin family B member 5 JBrowse link NW_004936497 2,067,796 2,089,965 RGD:9068941
G Serpine1 serpin family E member 1 JBrowse link NW_004936543 1,032,543 1,040,956 RGD:9068941
G Sesn1 sestrin 1 JBrowse link NW_004936564 5,187,152 5,291,201 RGD:9068941
G Sesn2 sestrin 2 JBrowse link NW_004936474 12,416,652 12,436,799 RGD:9068941
G Sesn3 sestrin 3 JBrowse link NW_004936700 2,429,535 2,491,752 RGD:9068941
G Setd7 SET domain containing 7, histone lysine methyltransferase JBrowse link NW_004936535 8,094,479 8,143,108 RGD:9068941
G Sfn stratifin JBrowse link NW_004936474 11,274,927 11,279,427 RGD:9068941
G Shisa5 shisa family member 5 JBrowse link NW_004936529 266,671 292,103 RGD:9068941
G Siah1 siah E3 ubiquitin protein ligase 1 JBrowse link NW_004936475 1,589,997 1,621,506 RGD:9068941
G Sirt1 sirtuin 1 JBrowse link NW_004936521 10,296,097 10,316,673 RGD:9068941
G Skp2 S-phase kinase associated protein 2 JBrowse link NW_004936518 5,635,856 5,664,057 RGD:9068941
G Smyd2 SET and MYND domain containing 2 JBrowse link NW_004936628 3,917,898 3,965,382 RGD:9068941
G Steap3 STEAP3 metalloreductase JBrowse link NW_004936469 51,084,250 51,121,738 RGD:9068941
G Thbs1 thrombospondin 1 JBrowse link NW_004936471 3,064,466 3,081,125 RGD:9068941
G Tp53 tumor protein p53 JBrowse link NW_004936595 919,807 935,367 RGD:9068941
G Tp53bp2 tumor protein p53 binding protein 2 JBrowse link NW_004936526 936,981 1,000,070 RGD:9068941
G Tp53i3 tumor protein p53 inducible protein 3 JBrowse link NW_004936493 7,897,757 7,906,106 RGD:9068941
G Tp73 tumor protein p73 JBrowse link NW_004936737 171,894 211,464 RGD:9068941
G Trim28 tripartite motif containing 28 JBrowse link NW_004937062 126,832 132,938 RGD:9068941
G Tsc2 TSC complex subunit 2 JBrowse link NW_004936694 1,958,152 1,993,373 RGD:9068941
G Ttc5 tetratricopeptide repeat domain 5 JBrowse link NW_004936877 504,406 520,295 RGD:9068941
G Ube2d1 ubiquitin conjugating enzyme E2 D1 JBrowse link NW_004936614 4,621,702 4,655,200 RGD:9068941
G Usp7 ubiquitin specific peptidase 7 JBrowse link NW_004936530 7,693,681 7,724,215 RGD:9068941
G Ybx1 Y-box binding protein 1 JBrowse link NW_004936474 24,026,459 24,047,724 RGD:9068941
G Yy1 YY1 transcription factor JBrowse link NW_004936604 3,911,407 3,945,405 RGD:9068941
G Zmat3 zinc finger matrin-type 3 JBrowse link NW_004936566 4,066,683 4,102,643 RGD:9068941
G Znf385a zinc finger protein 385A JBrowse link NW_004936512 11,562,635 11,585,026 RGD:9068941
G Znhit1 zinc finger HIT-type containing 1 JBrowse link NW_004936543 1,098,095 1,104,731 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5482
    regulatory pathway 3362
      pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis 1586
        cell cycle pathway 216
          cell cycle checkpoint pathway 126
            G1/S DNA damage checkpoint pathway 125
              p53-dependent G1/S DNA damage checkpoint pathway 125
                p53 signaling pathway + 125
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.