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ONTOLOGY REPORT - ANNOTATIONS


Term:eicosanoid signaling pathway
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Accession:PW:0000565 term browser browse the term
Definition:Eicosanoids, derived from omega-3 or omega-6 fatty acids, are represented by the leukotriene and prostanoid classes of which the latter is represented by several families. Some can act as endogenous ligands for members of the peroxisomal proliferator-activated nuclear receptors (PPARs). Once activated, PPARs heterodimerize with the retinoid X receptor (RXR) and modulate the expression of target genes.
Synonyms:related_synonym: PID:200082
 alt_id: PW:0001294


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eicosanoid signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6484113
G Arhgef1 Rho guanine nucleotide exchange factor 1 JBrowse link 1 81,769,212 81,797,237 RGD:6484113
G Arr3 arrestin 3 JBrowse link X 70,438,590 70,452,140 RGD:6484113
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:6484113
G Blk BLK proto-oncogene, Src family tyrosine kinase JBrowse link 15 46,555,552 46,593,778 RGD:6484113
G Dnm1 dynamin 1 JBrowse link 3 11,338,081 11,382,043 RGD:6484113
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6484113
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6484113
G Fgr FGR proto-oncogene, Src family tyrosine kinase JBrowse link 5 151,172,189 151,199,746 RGD:6484113
G Fyn FYN proto-oncogene, Src family tyrosine kinase JBrowse link 20 44,436,354 44,630,316 RGD:6484113
G Gna11 G protein subunit alpha 11 JBrowse link 7 11,033,400 11,047,284 RGD:6484113
G Gna12 G protein subunit alpha 12 JBrowse link 12 15,890,202 15,971,212 RGD:6484113
G Gna13 G protein subunit alpha 13 JBrowse link 10 97,647,196 97,680,030 RGD:6484113
G Gna14 G protein subunit alpha 14 JBrowse link 1 235,165,775 235,347,986 RGD:6484113
G Gna15 G protein subunit alpha 15 JBrowse link 7 11,054,249 11,075,152 RGD:6484113
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:6484113
G Gnaq G protein subunit alpha q JBrowse link 1 233,382,778 233,622,584 RGD:6484113
G Gnb1 G protein subunit beta 1 JBrowse link 5 172,914,025 172,981,403 RGD:6484113
G Gnb5 G protein subunit beta 5 JBrowse link 8 82,248,951 82,286,493 RGD:6484113
G Gng2 G protein subunit gamma 2 JBrowse link 15 4,748,242 4,853,555 RGD:6484113
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:6484113
G Grk3 G protein-coupled receptor kinase 3 JBrowse link 12 49,626,871 49,750,389 RGD:6484113
G Hck HCK proto-oncogene, Src family tyrosine kinase JBrowse link 3 148,579,917 148,623,026 RGD:6484113
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:6484113
G Lck LCK proto-oncogene, Src family tyrosine kinase JBrowse link 5 147,750,976 147,779,627 RGD:6484113
G Lyn LYN proto-oncogene, Src family tyrosine kinase JBrowse link 5 16,526,058 16,642,648 RGD:6484113
G Mapk11 mitogen-activated protein kinase 11 JBrowse link 7 130,121,678 130,129,199 RGD:6484113
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6484113
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6484113
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma JBrowse link 6 51,465,696 51,501,234 RGD:6484113
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6484113
G Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 JBrowse link 10 55,085,269 55,135,069 RGD:6484113
G Plcb2 phospholipase C, beta 2 JBrowse link 3 110,497,760 110,517,563 RGD:6484113
G Prkaca protein kinase cAMP-activated catalytic subunit alpha JBrowse link 19 25,095,089 25,118,869 RGD:6484113
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:6484113
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:6484113
G Prkce protein kinase C, epsilon JBrowse link 6 9,483,400 9,973,396 RGD:6484113
G Prkcg protein kinase C, gamma JBrowse link 1 64,407,098 64,433,698 RGD:6484113
G Prkch protein kinase C, eta JBrowse link 6 96,479,243 96,677,368 RGD:6484113
G Prkcq protein kinase C, theta JBrowse link 17 70,971,915 71,105,286 RGD:6484113
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:6484113
G Prkg1 protein kinase cGMP-dependent 1 JBrowse link 1 248,982,039 250,300,952 RGD:6484113
G Ptgdr prostaglandin D2 receptor JBrowse link 15 19,195,606 19,196,508 RGD:6484113
G Ptgir prostaglandin I2 receptor JBrowse link 1 78,833,449 78,835,832 RGD:6484113
G Rab11a RAB11a, member RAS oncogene family JBrowse link 8 70,192,975 70,215,719 RGD:6484113
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:6484113
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:6484113
G Rock1 Rho-associated coiled-coil containing protein kinase 1 JBrowse link 18 1,273,490 1,390,790 RGD:6484113
G Sele selectin E JBrowse link 13 82,355,234 82,365,323 RGD:6484113
G Slc9a3r1 SLC9A3 regulator 1 JBrowse link 10 103,713,045 103,730,145 RGD:6484113
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:6484113
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:6484113
G Tbxa2r thromboxane A2 receptor JBrowse link 7 11,253,153 11,259,233 RGD:6484113
G Tgm2 transglutaminase 2 JBrowse link 3 154,597,165 154,627,257 RGD:6484113
G Vcam1 vascular cell adhesion molecule 1 JBrowse link 2 219,071,193 219,090,931 RGD:6484113
G Yes1 YES proto-oncogene 1, Src family tyrosine kinase JBrowse link 9 121,802,471 121,918,906 RGD:6484113
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acaa1a acetyl-CoA acyltransferase 1A JBrowse link 8 128,027,880 128,036,471 RGD:6907045
G Acaa1b acetyl-Coenzyme A acyltransferase 1B JBrowse link 8 127,836,235 127,845,296 RGD:6907045
G Acadl acyl-CoA dehydrogenase, long chain JBrowse link 9 73,833,368 73,871,857 RGD:6907045
G Acadm acyl-CoA dehydrogenase medium chain JBrowse link 2 260,124,418 260,148,589 RGD:6907045
G Acox1 acyl-CoA oxidase 1 JBrowse link 10 104,724,534 104,748,003 RGD:6907045
G Acox2 acyl-CoA oxidase 2 JBrowse link 15 18,449,304 18,481,472 RGD:6907045
G Acox3 acyl-CoA oxidase 3, pristanoyl JBrowse link 14 80,313,202 80,358,115 RGD:6907045
G Acsbg1 acyl-CoA synthetase bubblegum family member 1 JBrowse link 8 59,184,111 59,240,133 RGD:6907045
G Acsbg2 acyl-CoA synthetase bubblegum family member 2 JBrowse link 9 10,172,317 10,203,550 RGD:6907045
G Acsl1 acyl-CoA synthetase long-chain family member 1 JBrowse link 16 48,937,456 49,003,898 RGD:6907045
G Acsl3 acyl-CoA synthetase long-chain family member 3 JBrowse link 9 84,569,601 84,593,565 RGD:6907045
G Acsl4 acyl-CoA synthetase long-chain family member 4 JBrowse link X 113,596,247 113,660,024 RGD:6907045
G Acsl5 acyl-CoA synthetase long-chain family member 5 JBrowse link 1 276,240,703 276,290,012 RGD:6907045
G Acsl6 acyl-CoA synthetase long-chain family member 6 JBrowse link 10 39,654,771 39,717,592 RGD:6907045
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:6907045
G Angptl4 angiopoietin-like 4 JBrowse link 7 18,627,814 18,634,043 RGD:6907045
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:6907045
G Apoa2 apolipoprotein A2 JBrowse link 13 89,596,872 89,598,805 RGD:6907045
G Apoa5 apolipoprotein A5 JBrowse link 8 50,559,079 50,561,720 RGD:6907045
G Apoc3 apolipoprotein C3 JBrowse link 8 50,529,318 50,531,498 RGD:6907045
G Aqp7 aquaporin 7 JBrowse link 5 57,358,297 57,372,332 RGD:6907045
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:6907045
G Cpt1a carnitine palmitoyltransferase 1A JBrowse link 1 218,568,157 218,629,679 RGD:6907045
G Cpt1b carnitine palmitoyltransferase 1B JBrowse link 7 130,395,211 130,404,731 RGD:6907045
G Cpt1c carnitine palmitoyltransferase 1c JBrowse link 1 100,955,094 100,970,579 RGD:6907045
G Cpt2 carnitine palmitoyltransferase 2 JBrowse link 5 127,505,646 127,523,016 RGD:6907045
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 JBrowse link 9 81,968,285 81,998,213 RGD:6907045
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 JBrowse link 5 134,492,734 134,507,158 RGD:6907045
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 JBrowse link 5 134,196,910 134,207,888 RGD:6907045
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 JBrowse link 5 134,468,666 134,484,851 RGD:6907045
G Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 JBrowse link 5 133,978,953 134,008,255 RGD:6907045
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 JBrowse link 5 19,358,734 19,368,431 RGD:6907045
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 JBrowse link 8 130,548,418 130,550,388 RGD:6907045
G Dbi diazepam binding inhibitor, acyl-CoA binding protein JBrowse link 13 36,147,667 36,156,076 RGD:6907045
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase JBrowse link 11 82,945,104 82,978,364 RGD:6907045
G Fabp1 fatty acid binding protein 1 JBrowse link 4 99,063,181 99,066,957 RGD:6907045
G Fabp2 fatty acid binding protein 2 JBrowse link 2 227,080,912 227,083,654 RGD:6907045
G Fabp3 fatty acid binding protein 3 JBrowse link 5 148,528,854 148,535,597 RGD:6907045
G Fabp4 fatty acid binding protein 4 JBrowse link 2 93,792,666 93,797,267 RGD:6907045
G Fabp5 fatty acid binding protein 5 JBrowse link 2 93,981,662 93,985,322 RGD:6907045
G Fabp6 fatty acid binding protein 6 JBrowse link 10 29,191,621 29,196,593 RGD:6907045
G Fabp7 fatty acid binding protein 7 JBrowse link 20 40,769,624 40,773,156 RGD:6907045
G Fads2 fatty acid desaturase 2 JBrowse link 1 225,906,582 226,152,568 RGD:6907045
G Gk glycerol kinase JBrowse link X 54,227,291 54,303,897 RGD:6907045
G Gk2 glycerol kinase 2 JBrowse link 14 13,751,284 13,753,136 RGD:6907045
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 JBrowse link 2 200,452,623 200,480,785 RGD:6907045
G Ilk integrin-linked kinase JBrowse link 1 170,578,941 170,585,192 RGD:6907045
G Lpl lipoprotein lipase JBrowse link 16 22,537,687 22,561,487 RGD:6907045
G Me1 malic enzyme 1 JBrowse link 8 94,256,830 94,368,834 RGD:6907045
G Mmp1 matrix metallopeptidase 1 JBrowse link 8 5,703,206 5,723,593 RGD:6907045
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 JBrowse link 3 80,004,130 80,014,197 RGD:6907045
G Olr1 oxidized low density lipoprotein receptor 1 JBrowse link 4 163,239,853 163,261,937 RGD:6907045
G Pck1 phosphoenolpyruvate carboxykinase 1 JBrowse link 3 171,213,936 171,219,885 RGD:6907045
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) JBrowse link 15 34,216,735 34,224,357 RGD:6907045
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6907045
G Pltp phospholipid transfer protein JBrowse link 3 161,304,469 161,322,289 RGD:6907045
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:6907045
G Ppard peroxisome proliferator-activated receptor delta JBrowse link 20 7,818,289 7,883,482 RGD:6907045
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6907045
G RGD1565355 similar to fatty acid translocase/CD36 JBrowse link 4 14,071,705 14,112,330 RGD:6907045
G Rxra retinoid X receptor alpha JBrowse link 3 6,272,560 6,295,354 RGD:6907045
G Rxrb retinoid X receptor beta JBrowse link 20 3,822,673 3,829,138 RGD:6907045
G Rxrg retinoid X receptor gamma JBrowse link 13 85,818,473 85,868,555 RGD:6907045
G Scd stearoyl-CoA desaturase JBrowse link 1 264,159,966 264,173,061 RGD:6907045
G Scd2 stearoyl-Coenzyme A desaturase 2 JBrowse link 1 264,059,374 264,072,433 RGD:6907045
G Scd4 stearoyl-coenzyme A desaturase 4 JBrowse link 1 264,094,007 264,105,473 RGD:6907045
G Scp2 sterol carrier protein 2 JBrowse link 5 127,647,934 127,735,703 RGD:6907045
G Slc27a1 solute carrier family 27 member 1 JBrowse link 16 19,997,823 20,016,193 RGD:6907045
G Slc27a2 solute carrier family 27 member 2 JBrowse link 3 119,014,620 119,052,531 RGD:6907045
G Slc27a4 solute carrier family 27 member 4 JBrowse link 3 8,363,937 8,376,858 RGD:6907045
G Slc27a5 solute carrier family 27 member 5 JBrowse link 1 65,576,599 65,587,192 RGD:6907045
G Slc27a6 solute carrier family 27 member 6 JBrowse link 18 53,609,497 53,667,833 RGD:6907045
G Sorbs1 sorbin and SH3 domain containing 1 JBrowse link 1 259,373,921 259,502,108 RGD:6907045
G Ubc ubiquitin C JBrowse link 12 36,638,457 36,642,734 RGD:6907045
G Ucp1 uncoupling protein 1 JBrowse link 19 24,456,976 24,464,808 RGD:6907045
prostaglandin D2 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adcy2 adenylate cyclase 2 JBrowse link 1 37,043,071 37,698,390 RGD:10402751
G Gnas GNAS complex locus JBrowse link 3 172,374,957 172,434,988 RGD:10402751
G Gnb1 G protein subunit beta 1 JBrowse link 5 172,914,025 172,981,403 RGD:10402751
G Gng12 G protein subunit gamma 12 JBrowse link 4 97,634,925 97,763,478 RGD:10402751
G Prkacb protein kinase cAMP-activated catalytic subunit beta JBrowse link 2 252,602,197 252,691,886 RGD:10402751
G Ptgdr prostaglandin D2 receptor JBrowse link 15 19,195,606 19,196,508 RGD:10402751
prostaglandin I2 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adcy2 adenylate cyclase 2 JBrowse link 1 37,043,071 37,698,390 RGD:10402751
G Gnas GNAS complex locus JBrowse link 3 172,374,957 172,434,988 RGD:10402751
G Gnb1 G protein subunit beta 1 JBrowse link 5 172,914,025 172,981,403 RGD:10402751
G Gng12 G protein subunit gamma 12 JBrowse link 4 97,634,925 97,763,478 RGD:10402751
G Myl3 myosin light chain 3 JBrowse link 8 119,030,852 119,036,996 RGD:10402751
G Mylk myosin light chain kinase JBrowse link 11 69,013,060 69,260,039 RGD:10402751
G Prkacb protein kinase cAMP-activated catalytic subunit beta JBrowse link 2 252,602,197 252,691,886 RGD:10402751
G Ptgir prostaglandin I2 receptor JBrowse link 1 78,833,449 78,835,832 RGD:10402751

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6016
    signaling pathway 2585
      lipid signaling pathway 275
        eicosanoid signaling pathway 137
          eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma 75
          leukotriene signaling pathway 0
          prostanoid signaling pathway + 9
Path 2
Term Annotations click to browse term
  pathway 6016
    signaling pathway 2585
      hormone signaling pathway 619
        lipid hormone signaling pathway 223
          eicosanoid signaling pathway 137
            eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma 75
            leukotriene signaling pathway 0
            prostanoid signaling pathway + 9
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.