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ONTOLOGY REPORT - ANNOTATIONS


Term:eicosanoid signaling pathway
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Accession:PW:0000565 term browser browse the term
Definition:Eicosanoids, derived from omega-3 or omega-6 fatty acids, are represented by the leukotriene and prostanoid classes of which the latter is represented by several families. Some can act as endogenous ligands for members of the peroxisomal proliferator-activated nuclear receptors (PPARs). Once activated, PPARs heterodimerize with the retinoid X receptor (RXR) and modulate the expression of target genes.
Synonyms:related_synonym: PID:200082
 alt_id: PW:0001294


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eicosanoid signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AKT1 AKT serine/threonine kinase 1 RGD:9068941
G ARHGEF1 Rho guanine nucleotide exchange factor 1 JBrowse link 6 49,975,957 49,995,442 RGD:9068941
G ARR3 arrestin 3 JBrowse link X 56,295,107 56,310,507 RGD:9068941
G ARRB2 arrestin beta 2 JBrowse link 12 52,161,776 52,170,362 RGD:9068941
G BLK BLK proto-oncogene, Src family tyrosine kinase JBrowse link 14 14,688,489 14,745,946 RGD:9068941
G DNM1 dynamin 1 JBrowse link 1 268,653,045 268,702,233 RGD:9068941
G EGF epidermal growth factor JBrowse link 8 112,235,607 112,330,062 RGD:9068941
G EGFR epidermal growth factor receptor JBrowse link 9 139,302,410 139,474,632 RGD:9068941
G FGR FGR proto-oncogene, Src family tyrosine kinase JBrowse link 6 84,809,534 84,830,401 RGD:9068941
G FYN FYN proto-oncogene, Src family tyrosine kinase JBrowse link 1 77,584,675 77,810,605 RGD:9068941
G GNA11 G protein subunit alpha 11 JBrowse link 2 75,439,405 75,456,855 RGD:9068941
G GNA12 G protein subunit alpha 12 JBrowse link 3 2,002,494 2,105,937 RGD:9068941
G GNA13 G protein subunit alpha 13 JBrowse link 12 11,922,630 11,966,913 RGD:9068941
G GNA14 G protein subunit alpha 14 JBrowse link 1 230,341,947 230,545,123 RGD:9068941
G GNA15 G protein subunit alpha 15 JBrowse link 2 75,408,723 75,433,809 RGD:9068941
G GNAI2 G protein subunit alpha i2 JBrowse link 13 32,705,326 32,733,804 RGD:9068941
G GNAQ G protein subunit alpha q JBrowse link 1 230,607,469 230,906,988 RGD:9068941
G GNB1 G protein subunit beta 1 JBrowse link 6 63,867,155 63,957,514 RGD:9068941
G GNB5 G protein subunit beta 5 JBrowse link 1 119,545,382 119,589,860 RGD:9068941
G GNG2 G protein subunit gamma 2 JBrowse link 1 181,485,257 181,651,972 RGD:9068941
G GRK2 G protein-coupled receptor kinase 2 JBrowse link 2 5,209,435 5,227,543 RGD:9068941
G GRK3 G protein-coupled receptor kinase 3 JBrowse link 14 43,305,255 43,445,626 RGD:9068941
G HCK HCK proto-oncogene, Src family tyrosine kinase JBrowse link 17 35,708,549 35,751,590 RGD:9068941
G ICAM1 intercellular adhesion molecule 1 JBrowse link 2 69,097,136 69,107,722 RGD:9068941
G LCK LCK proto-oncogene, Src family tyrosine kinase JBrowse link 6 88,719,886 88,745,922 RGD:9068941
G LYN LYN proto-oncogene, Src family tyrosine kinase JBrowse link 4 75,793,273 75,903,710 RGD:9068941
G MAPK11 mitogen-activated protein kinase 11 JBrowse link 5 420,848 428,103 RGD:9068941
G MAPK14 mitogen-activated protein kinase 14 JBrowse link 7 31,791,398 31,861,544 RGD:9068941
G NOS3 nitric oxide synthase 3 JBrowse link 18 6,209,218 6,228,912 RGD:9068941
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma JBrowse link 9 106,698,200 106,748,217 RGD:9068941
G PIK3R5 phosphoinositide-3-kinase regulatory subunit 5 JBrowse link 12 53,979,206 54,046,927 RGD:9068941
G PIK3R6 phosphoinositide-3-kinase regulatory subunit 6 JBrowse link 12 53,910,999 53,971,088 RGD:9068941
G PLCB2 phospholipase C beta 2 JBrowse link 1 131,005,408 131,031,864 RGD:9068941
G PRKACA protein kinase cAMP-activated catalytic subunit alpha JBrowse link 2 65,074,876 65,095,564 RGD:9068941
G PRKCA protein kinase C alpha JBrowse link 12 12,882,287 13,268,647 RGD:9068941
G PRKCD protein kinase C delta JBrowse link 13 35,290,835 35,323,245 RGD:9068941
G PRKCE protein kinase C epsilon JBrowse link 3 94,351,277 94,864,549 RGD:9068941
G PRKCG protein kinase C gamma JBrowse link 6 56,213,479 56,235,683 RGD:9068941
G PRKCH protein kinase C eta JBrowse link 1 190,205,041 190,439,433 RGD:9068941
G PRKCQ protein kinase C theta JBrowse link 10 64,442,588 64,596,528 RGD:9068941
G PRKCZ protein kinase C zeta JBrowse link 6 64,073,343 64,159,187 RGD:9068941
G PRKG1 protein kinase cGMP-dependent 1 JBrowse link 14 97,558,531 98,793,080 RGD:9068941
G PTGIR prostaglandin I2 receptor JBrowse link 6 52,522,639 52,527,338 RGD:9068941
G RAB11A RAB11A, member RAS oncogene family JBrowse link 1 163,858,254 163,887,741 RGD:9068941
G RAC1 Rac family small GTPase 1 JBrowse link 3 4,781,776 4,803,510 RGD:9068941
G RHOA ras homolog family member A JBrowse link 13 31,918,484 31,991,207 RGD:9068941
G ROCK1 Rho associated coiled-coil containing protein kinase 1 JBrowse link 6 106,163,899 106,314,998 RGD:9068941
G SELE selectin E JBrowse link 4 81,289,061 81,299,657 RGD:9068941
G SLC9A3R1 SLC9A3 regulator 1 JBrowse link 12 6,466,138 6,483,539 RGD:9068941
G SRC SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 17 40,470,970 40,524,862 RGD:9068941
G SYK spleen associated tyrosine kinase JBrowse link 14 2,103,706 2,160,886 RGD:9068941
G TBXA2R thromboxane A2 receptor JBrowse link 2 75,068,413 75,081,305 RGD:9068941
G TGM2 transglutaminase 2 JBrowse link 17 41,186,765 41,221,686 RGD:9068941
G VCAM1 vascular cell adhesion molecule 1 JBrowse link 4 117,496,914 117,511,211 RGD:9068941
G YES1 YES proto-oncogene 1, Src family tyrosine kinase JBrowse link 6 105,505,944 105,600,694 RGD:9068941
prostaglandin D2 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADCY2 adenylate cyclase 2 JBrowse link 16 74,305,729 74,729,999 RGD:9068941
G GNAS GNAS complex locus JBrowse link 17 58,985,580 59,053,022 RGD:9068941
G GNB1 G protein subunit beta 1 JBrowse link 6 63,867,155 63,957,514 RGD:9068941
G GNG12 G protein subunit gamma 12 JBrowse link 6 144,782,478 144,918,556 RGD:9068941
G PRKACB protein kinase cAMP-activated catalytic subunit beta JBrowse link 6 129,520,397 129,636,207 RGD:9068941
prostaglandin I2 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADCY2 adenylate cyclase 2 JBrowse link 16 74,305,729 74,729,999 RGD:9068941
G GNAS GNAS complex locus JBrowse link 17 58,985,580 59,053,022 RGD:9068941
G GNB1 G protein subunit beta 1 JBrowse link 6 63,867,155 63,957,514 RGD:9068941
G GNG12 G protein subunit gamma 12 JBrowse link 6 144,782,478 144,918,556 RGD:9068941
G MYL3 myosin light chain 3 JBrowse link 13 29,730,271 29,735,616 RGD:9068941
G MYLK myosin light chain kinase JBrowse link 13 136,509,878 136,809,674 RGD:9068941
G PRKACB protein kinase cAMP-activated catalytic subunit beta JBrowse link 6 129,520,397 129,636,207 RGD:9068941
G PTGIR prostaglandin I2 receptor JBrowse link 6 52,522,639 52,527,338 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5633
    signaling pathway 2422
      lipid signaling pathway 206
        eicosanoid signaling pathway 61
          eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma 0
          leukotriene signaling pathway 0
          prostanoid signaling pathway + 8
Path 2
Term Annotations click to browse term
  pathway 5633
    signaling pathway 2422
      hormone signaling pathway 551
        lipid hormone signaling pathway 144
          eicosanoid signaling pathway 61
            eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma 0
            leukotriene signaling pathway 0
            prostanoid signaling pathway + 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.