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Term:endometrial cancer pathway
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Accession:PW:0000611 term browser browse the term
Definition:Endometrial cancer affects the lining of the uterus, or endometrium. Hormonal and genetic alterations play a role in the development of this carcinoma type. Mutations in genes acting in several pathways have been associated with the condition and its types.
Synonyms:related_synonym: KEGG:05213;   endometrial neoplasm pathway

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endometrial cancer pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link NW_004955538 3,208,711 3,224,386 RGD:9068941
G Akt2 AKT serine/threonine kinase 2 JBrowse link NW_004955578 950,258 1,004,438 RGD:9068941
G Akt3 AKT serine/threonine kinase 3 JBrowse link NW_004955406 6,907,876 7,163,672 RGD:9068941
G Apc APC regulator of WNT signaling pathway JBrowse link NW_004955418 2,567,804 2,675,062 RGD:9068941
G Apc2 APC regulator of WNT signaling pathway 2 JBrowse link NW_004955495 6,466,434 6,489,612 RGD:9068941
G Araf A-Raf proto-oncogene, serine/threonine kinase JBrowse link NW_004955516 521,479 532,980 RGD:9068941
G Axin1 axin 1 JBrowse link NW_004955442 16,845,728 16,898,301 RGD:9068941
G Axin2 axin 2 JBrowse link NW_004955478 4,952,551 4,982,223 RGD:9068941
G Bad BCL2 associated agonist of cell death JBrowse link NW_004955422 20,795,585 20,809,039 RGD:9068941
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link NW_004955494 2,567,238 2,712,708 RGD:9068941
G Casp9 caspase 9 JBrowse link NW_004955527 2,613,691 2,630,217 RGD:9068941
G Ccnd1 cyclin D1 JBrowse link NW_004955422 16,449,921 16,462,676 RGD:9068941
G Cdh1 cadherin 1 JBrowse link NW_004955484 7,782,409 7,861,082 RGD:9068941
G Ctnna1 catenin alpha 1 JBrowse link NW_004955418 1,592,555 1,754,423 RGD:9068941
G Ctnna2 catenin alpha 2 JBrowse link NW_004955424 5,985,170 7,055,830 RGD:9068941
G Ctnna3 catenin alpha 3 JBrowse link NW_004955425 18,623,645 20,126,200 RGD:9068941
G Ctnnb1 catenin beta 1 JBrowse link NW_004955420 29,030,716 29,047,447 RGD:9068941
G Egf epidermal growth factor JBrowse link NW_004955496 325,954 401,430 RGD:9068941
G Egfr epidermal growth factor receptor JBrowse link NW_004955456 321,222 456,431 RGD:9068941
G Elk1 ETS transcription factor ELK1 JBrowse link NW_004955516 431,081 444,871 RGD:9068941
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link NW_004955451 14,442,816 14,456,009 RGD:9068941
G Foxo3 forkhead box O3 JBrowse link NW_004955411 33,655,958 33,770,829 RGD:9068941
G Grb2 growth factor receptor bound protein 2 JBrowse link NW_004955553 2,186,590 2,258,964 RGD:9068941
G Gsk3b glycogen synthase kinase 3 beta JBrowse link NW_004955427 19,489,972 19,671,137 RGD:9068941
G Hras HRas proto-oncogene, GTPase JBrowse link NW_004955476 11,508,446 11,510,333 RGD:9068941
G Ilk integrin linked kinase JBrowse link NW_004955414 22,316,243 22,322,979 RGD:9068941
G Kras KRAS proto-oncogene, GTPase JBrowse link NW_004955413 20,298,852 20,328,756 RGD:9068941
G Lef1 lymphoid enhancer binding factor 1 JBrowse link NW_004955496 1,728,840 1,827,749 RGD:9068941
G Map2k1 mitogen-activated protein kinase kinase 1 JBrowse link NW_004955450 9,181,851 9,205,277 RGD:9068941
G Map2k2 mitogen-activated protein kinase kinase 2 JBrowse link NW_004955495 4,695,239 4,718,380 RGD:9068941
G Mapk1 mitogen-activated protein kinase 1 JBrowse link NW_004955442 17,284,232 17,380,026 RGD:9068941
G Mapk3 mitogen-activated protein kinase 3 JBrowse link NW_004955493 6,870,699 6,876,836 RGD:9068941
G Mlh1 mutL homolog 1 JBrowse link NW_004955421 3,890,291 3,936,892 RGD:9068941
G Msh6 mutS homolog 6 JBrowse link NW_004955441 14,451,207 14,471,316 RGD:9068941
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link NW_004955461 2,714,022 2,718,872 RGD:9068941
G Nras NRAS proto-oncogene, GTPase JBrowse link NW_004955435 18,001,517 18,009,105 RGD:9068941
G Pdpk1 3-phosphoinositide dependent protein kinase 1 JBrowse link NW_004955442 14,685,089 14,772,870 RGD:9068941
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link NW_004955420 8,355,415 8,427,024 RGD:9068941
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta JBrowse link NW_004955501 251,829 381,255 RGD:9068941
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta JBrowse link NW_004955486 3,813,923 3,837,563 RGD:9068941
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma JBrowse link NW_004955410 11,402,476 11,433,335 RGD:9068941
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link NW_004955446 1,020,707 1,098,327 RGD:9068941
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link NW_004955524 3,234,111 3,241,445 RGD:9068941
G Pik3r5 phosphoinositide-3-kinase regulatory subunit 5 JBrowse link NW_004955467 8,025,231 8,091,406 RGD:9068941
G Pten phosphatase and tensin homolog JBrowse link NW_004955425 5,007,811 5,091,829 RGD:9068941
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link NW_004955429 17,980,956 18,049,723 RGD:9068941
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link NW_004955441 6,649,895 6,724,271 RGD:9068941
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link NW_004955409 12,542,353 12,622,165 RGD:9068941
G Tcf7 transcription factor 7 JBrowse link NW_004955408 5,362,423 5,388,684 RGD:9068941
G Tcf7l1 transcription factor 7 like 1 JBrowse link NW_004955424 2,139,576 2,286,183 RGD:9068941
G Tcf7l2 transcription factor 7 like 2 JBrowse link NW_004955431 18,020,309 18,207,926 RGD:9068941
G Tp53 tumor protein p53 JBrowse link NW_004955467 9,241,391 9,256,716 RGD:9068941

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  pathway 5435
    disease pathway 1797
      cancer pathway 378
        urogenital cancer pathway 163
          endometrial cancer pathway 52
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.