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ONTOLOGY REPORT - ANNOTATIONS


Term:endometrial cancer pathway
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Accession:PW:0000611 term browser browse the term
Definition:Endometrial cancer affects the lining of the uterus, or endometrium. Hormonal and genetic alterations play a role in the development of this carcinoma type. Mutations in genes acting in several pathways have been associated with the condition and its types.
Synonyms:related_synonym: KEGG:05213;   endometrial neoplasm pathway

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endometrial cancer pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AKT1 AKT serine/threonine kinase 1 JBrowse link 14 104,769,349 104,795,748 RGD:6907045
G AKT2 AKT serine/threonine kinase 2 JBrowse link 19 40,230,317 40,285,531 RGD:6907045
RGD:13432140
G AKT3 AKT serine/threonine kinase 3 JBrowse link 1 243,488,233 243,851,079 RGD:6907045
G APC APC regulator of WNT signaling pathway JBrowse link 5 112,707,498 112,846,239 RGD:6907045
RGD:13432145
G APC2 APC regulator of WNT signaling pathway 2 JBrowse link 19 1,446,268 1,473,244 RGD:6907045
G ARAF A-Raf proto-oncogene, serine/threonine kinase JBrowse link X 47,561,100 47,571,921 RGD:6907045
G AXIN1 axin 1 JBrowse link 16 287,440 355,226 RGD:6907045
G AXIN2 axin 2 JBrowse link 17 65,528,563 65,561,648 RGD:6907045
RGD:13432159
G BAD BCL2 associated agonist of cell death JBrowse link 11 64,269,828 64,284,704 RGD:6907045
RGD:13432162
G BRAF B-Raf proto-oncogene, serine/threonine kinase JBrowse link 7 140,719,331 140,924,929 RGD:6907045
G CASP9 caspase 9 JBrowse link 1 15,491,401 15,524,912 RGD:6907045
RGD:13432196
G CCND1 cyclin D1 JBrowse link 11 69,641,156 69,654,474 RGD:6907045
G CDH1 cadherin 1 JBrowse link 16 68,737,292 68,835,537 RGD:6907045
G CTNNA1 catenin alpha 1 JBrowse link 5 138,753,386 138,935,034 RGD:6907045
G CTNNA2 catenin alpha 2 JBrowse link 2 79,505,054 80,648,868 RGD:6907045
G CTNNA3 catenin alpha 3 JBrowse link 10 65,912,518 67,696,217 RGD:6907045
G CTNNB1 catenin beta 1 JBrowse link 3 41,199,422 41,240,445 RGD:4143515
RGD:6907045
G EGF epidermal growth factor JBrowse link 4 109,912,883 110,013,766 RGD:6907045
G EGFR epidermal growth factor receptor JBrowse link 7 55,019,017 55,211,628 RGD:6907045
G ELK1 ETS transcription factor ELK1 JBrowse link X 47,635,520 47,650,604 RGD:6907045
G ERBB2 erb-b2 receptor tyrosine kinase 2 JBrowse link 17 39,688,084 39,728,662 RGD:4143515
RGD:6907045
G FOXO3 forkhead box O3 JBrowse link 6 108,559,825 108,684,774 RGD:6907045
G GRB2 growth factor receptor bound protein 2 JBrowse link 17 75,318,076 75,405,709 RGD:6907045
G GSK3B glycogen synthase kinase 3 beta JBrowse link 3 119,821,321 120,095,823 RGD:6907045
G HRAS HRas proto-oncogene, GTPase JBrowse link 11 532,242 535,576 RGD:6907045
G ILK integrin linked kinase JBrowse link 11 6,603,708 6,610,874 RGD:6907045
G KRAS KRAS proto-oncogene, GTPase JBrowse link 12 25,205,246 25,250,929 RGD:4143515
RGD:6907045
G LEF1 lymphoid enhancer binding factor 1 JBrowse link 4 108,047,545 108,168,956 RGD:6907045
G MAP2K1 mitogen-activated protein kinase kinase 1 JBrowse link 15 66,386,912 66,491,544 RGD:6907045
G MAP2K2 mitogen-activated protein kinase kinase 2 JBrowse link 19 4,090,321 4,124,184 RGD:6907045
G MAPK1 mitogen-activated protein kinase 1 JBrowse link 22 21,759,657 21,867,680 RGD:6907045
G MAPK3 mitogen-activated protein kinase 3 JBrowse link 16 30,114,105 30,123,309 RGD:6907045
G MLH1 mutL homolog 1 JBrowse link 3 36,993,350 37,050,846 RGD:4143515
RGD:6907045
G MSH6 mutS homolog 6 JBrowse link 2 47,783,082 47,806,954 RGD:4143515
G MYC MYC proto-oncogene, bHLH transcription factor JBrowse link 8 127,735,434 127,742,951 RGD:6907045
G NRAS NRAS proto-oncogene, GTPase JBrowse link 1 114,704,469 114,716,771 RGD:6907045
G PDPK1 3-phosphoinositide dependent protein kinase 1 JBrowse link 16 2,538,014 2,603,190 RGD:6907045
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link 3 179,148,114 179,240,093 RGD:4143515
RGD:6907045
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta JBrowse link 3 138,652,698 138,834,928 RGD:6907045
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta JBrowse link 1 9,629,889 9,729,114 RGD:6907045
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma JBrowse link 7 106,865,282 106,908,980 RGD:6907045
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 5 68,215,737 68,301,821 RGD:6907045
G PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 19 18,153,163 18,170,532 RGD:6907045
G PIK3R3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 1 46,040,140 46,174,901 RGD:6907045
G PIK3R5 phosphoinositide-3-kinase regulatory subunit 5 JBrowse link 17 8,878,916 8,965,712 RGD:6907045
G PTEN phosphatase and tensin homolog JBrowse link 10 87,863,625 87,971,930 RGD:4143515
RGD:6907045
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 3 12,583,601 12,664,201 RGD:6907045
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 2 38,981,549 39,124,959 RGD:6907045
G SOS2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 14 50,117,130 50,231,578 RGD:6907045
G TCF7 transcription factor 7 JBrowse link 5 134,114,681 134,148,229 RGD:6907045
G TCF7L1 transcription factor 7 like 1 JBrowse link 2 85,133,392 85,310,387 RGD:6907045
G TCF7L2 transcription factor 7 like 2 JBrowse link 10 112,950,247 113,167,678 RGD:6907045
G TP53 tumor protein p53 JBrowse link 17 7,668,402 7,687,550 RGD:4143515
RGD:6907045

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  pathway 5944
    disease pathway 2071
      cancer pathway 389
        urogenital cancer pathway 167
          endometrial cancer pathway 53
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.