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Term:endometrial cancer pathway
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Accession:PW:0000611 term browser browse the term
Definition:Endometrial cancer affects the lining of the uterus, or endometrium. Hormonal and genetic alterations play a role in the development of this carcinoma type. Mutations in genes acting in several pathways have been associated with the condition and its types.
Synonyms:related_synonym: KEGG:05213;   endometrial neoplasm pathway

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endometrial cancer pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link NW_004936621 620,163 639,115 RGD:9068941
G Akt2 AKT serine/threonine kinase 2 JBrowse link NW_004936661 2,652,568 2,694,039 RGD:9068941
G Akt3 AKT serine/threonine kinase 3 JBrowse link NW_004936526 6,944,056 7,201,226 RGD:9068941
G Apc APC regulator of WNT signaling pathway JBrowse link NW_004936531 6,899,580 7,019,016 RGD:9068941
G Apc2 APC regulator of WNT signaling pathway 2 JBrowse link NW_004936588 767,115 787,321 RGD:9068941
G Araf A-Raf proto-oncogene, serine/threonine kinase JBrowse link NW_004936502 13,323,365 13,335,003 RGD:9068941
G Axin1 axin 1 JBrowse link NW_004936501 599,963 633,837 RGD:9068941
G Axin2 axin 2 JBrowse link NW_004936541 7,155,963 7,242,466 RGD:9068941
G Bad BCL2 associated agonist of cell death JBrowse link NW_004936599 4,924,349 4,933,683 RGD:9068941
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link NW_004936592 4,728,371 4,833,830 RGD:9068941
G Casp9 caspase 9 JBrowse link NW_004936474 3,178,097 3,196,130 RGD:9068941
G Cdh1 cadherin 1 JBrowse link NW_004936475 18,990,529 19,065,954 RGD:9068941
G Ctnna1 catenin alpha 1 JBrowse link NW_004936531 7,865,907 8,036,020 RGD:9068941
G Ctnna2 catenin alpha 2 JBrowse link NW_004936556 5,205,481 6,271,304 RGD:9068941
G Ctnna3 catenin alpha 3 JBrowse link NW_004936521 10,482,434 10,936,554 RGD:9068941
G Ctnnb1 catenin beta 1 JBrowse link NW_004936473 29,999,542 30,034,610 RGD:9068941
G Egf epidermal growth factor JBrowse link NW_004936563 1,058,803 1,181,393 RGD:9068941
G Egfr epidermal growth factor receptor JBrowse link NW_004936678 365,005 560,546 RGD:9068941
G Elk1 ETS transcription factor ELK1 JBrowse link NW_004936502 13,402,726 13,418,214 RGD:9068941
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link NW_004936490 14,887,062 14,910,038 RGD:9068941
G Foxo3 forkhead box O3 JBrowse link NW_004936564 4,788,036 4,907,600 RGD:9068941
G Grb2 growth factor receptor bound protein 2 JBrowse link NW_004936594 592,760 661,369 RGD:9068941
G Gsk3b glycogen synthase kinase 3 beta JBrowse link NW_004936536 6,730,070 6,893,818 RGD:9068941
G Hras HRas proto-oncogene, GTPase JBrowse link NW_004936888 375,372 378,125 RGD:9068941
G Ilk integrin linked kinase JBrowse link NW_004936842 661,961 667,993 RGD:9068941
G Kras KRAS proto-oncogene, GTPase JBrowse link NW_004936548 2,078,568 2,113,877 RGD:9068941
G Lef1 lymphoid enhancer binding factor 1 JBrowse link NW_004936818 453,635 569,194 RGD:9068941
G Map2k1 mitogen-activated protein kinase kinase 1 JBrowse link NW_004936471 26,589,251 26,628,302 RGD:9068941
G Map2k2 mitogen-activated protein kinase kinase 2 JBrowse link NW_004936588 2,338,127 2,377,090 RGD:9068941
G Mapk1 mitogen-activated protein kinase 1 JBrowse link NW_004936619 1,889,841 1,932,646 RGD:9068941
G Mapk3 mitogen-activated protein kinase 3 JBrowse link NW_004936501 12,342,670 12,390,650 RGD:9068941
G Mlh1 mutL homolog 1 JBrowse link NW_004936473 26,556,636 26,600,830 RGD:9068941
G Msh6 mutS homolog 6 JBrowse link NW_004936508 4,708,661 4,728,671 RGD:9068941
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link NW_004936470 20,480,844 20,485,955 RGD:9068941
G Nras NRAS proto-oncogene, GTPase JBrowse link NW_004936627 73,413 82,590 RGD:9068941
G Pdpk1 3-phosphoinositide dependent protein kinase 1 JBrowse link NW_004936694 1,444,819 1,487,628 RGD:9068941
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link NW_004936566 3,924,013 3,951,052 RGD:9068941
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta JBrowse link NW_004936540 907,118 1,041,814 RGD:9068941
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta JBrowse link NW_004936623 3,672,201 3,696,959 RGD:9068941
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma JBrowse link NW_004936479 17,084,006 17,112,264 RGD:9068941
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link NW_004936480 1,188,408 1,273,210 RGD:9068941
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link NW_004936596 3,010,526 3,021,848 RGD:9068941
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link NW_004936474 27,095,125 27,171,416 RGD:9068941
G Pik3r5 phosphoinositide-3-kinase regulatory subunit 5 JBrowse link NW_004936595 2,029,074 2,053,954 RGD:9068941
G Pten phosphatase and tensin homolog JBrowse link NW_004936735 1,252,414 1,338,318 RGD:9068941
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link NW_004936602 1,089,979 1,114,376 RGD:9068941
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link NW_004936508 12,162,553 12,281,812 RGD:9068941
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link NW_004936495 15,286,524 15,365,598 RGD:9068941
G Tcf7 transcription factor 7 JBrowse link NW_004936647 1,096,726 1,125,753 RGD:9068941
G Tcf7l1 transcription factor 7 like 1 JBrowse link NW_004936712 1,848,478 1,962,644 RGD:9068941
G Tcf7l2 transcription factor 7 like 2 JBrowse link NW_004936486 3,473,877 3,660,565 RGD:9068941
G Tp53 tumor protein p53 JBrowse link NW_004936595 919,807 935,367 RGD:9068941

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  pathway 5482
    disease pathway 1841
      cancer pathway 382
        urogenital cancer pathway 164
          endometrial cancer pathway 52
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.