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ONTOLOGY REPORT - ANNOTATIONS


Term:Endoplasmic Reticulum-associated degradation pathway
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Accession:PW:0000638 term browser browse the term
Definition:In the endoplasmic reticulum correctly folded proteins are targeted for further export whereas misfolded proteins are retained and targeted for degradation.
Synonyms:related_synonym: ERAD pathway;   KEGG:04141


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Endoplasmic Reticulum-associated degradation pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Amfr autocrine motility factor receptor JBrowse link 19 11,473,538 11,509,500 RGD:6907045
G Atf4 activating transcription factor 4 JBrowse link 7 121,480,723 121,482,781 RGD:6907045
G Atf6 activating transcription factor 6 JBrowse link 13 89,053,457 89,242,531 RGD:6907045
G Atf6b activating transcription factor 6 beta JBrowse link 20 4,414,283 4,422,283 RGD:6907045
G Atxn3 ataxin 3 JBrowse link 6 125,817,420 125,853,461 RGD:6907045
G Bag1 BAG cochaperone 1 JBrowse link 5 57,254,421 57,267,002 RGD:6907045
G Bag2 BAG cochaperone 2 JBrowse link 9 38,456,487 38,467,120 RGD:6907045
G Bak1 BCL2-antagonist/killer 1 JBrowse link 20 5,609,620 5,618,899 RGD:6907045
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6907045
G Bcap31 B-cell receptor-associated protein 31 JBrowse link X 157,094,365 157,126,397 RGD:6907045
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6907045
G Calr calreticulin JBrowse link 19 25,956,771 25,961,666 RGD:6907045
G Canx calnexin JBrowse link 10 35,800,942 35,833,939 RGD:6907045
G Capn1 calpain 1 JBrowse link 1 221,346,081 221,370,965 RGD:6907045
G Capn2 calpain 2 JBrowse link 13 100,878,649 100,928,811 RGD:6907045
G Casp12 caspase 12 JBrowse link 8 2,658,892 2,686,160 RGD:6907045
G Ckap4 cytoskeleton-associated protein 4 JBrowse link 7 24,935,243 24,947,595 RGD:6907045
G Cryaa crystallin, alpha A JBrowse link 20 10,438,444 10,442,189 RGD:6907045
G Cryab crystallin, alpha B JBrowse link 8 55,178,543 55,182,546 RGD:6907045
G Cul1 cullin 1 JBrowse link 4 77,211,814 77,283,369 RGD:6907045
G Dad1 defender against cell death 1 JBrowse link 15 32,868,136 32,887,933 RGD:6907045
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6907045
G Ddost dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit JBrowse link 5 156,668,924 156,676,036 RGD:6907045
G Derl1 derlin 1 JBrowse link 7 97,737,176 97,759,852 RGD:6907045
G Derl3 derlin 3 JBrowse link 20 13,692,102 13,707,645 RGD:6907045
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 JBrowse link 5 57,028,467 57,039,378 RGD:6907045
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 JBrowse link 19 22,569,999 22,588,143 RGD:6907045
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 JBrowse link 19 24,747,178 24,750,919 RGD:6907045
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 JBrowse link 11 81,741,342 81,757,806 RGD:6907045
G Dnajb12 DnaJ heat shock protein family (Hsp40) member B12 JBrowse link 20 29,445,510 29,463,739 RGD:6907045
G Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 JBrowse link 9 82,436,453 82,444,669 RGD:6907045
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 JBrowse link 3 67,538,289 67,578,308 RGD:6907045
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 JBrowse link 15 104,186,918 104,226,236 RGD:6907045
G Dnajc5 DnaJ heat shock protein family (Hsp40) member C5 JBrowse link 3 177,012,714 177,047,787 RGD:6907045
G Dnajc5b DnaJ heat shock protein family (Hsp40) member C5 beta JBrowse link 2 104,290,726 104,382,846 RGD:6907045
G Dnajc5g DnaJ heat shock protein family (Hsp40) member C5 gamma JBrowse link 6 26,625,526 26,629,651 RGD:6907045
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 JBrowse link 4 140,886,644 140,918,654 RGD:6907045
G Edem2 ER degradation enhancing alpha-mannosidase like protein 2 JBrowse link 3 151,232,741 151,258,559 RGD:6907045
G Edem3 ER degradation enhancing alpha-mannosidase like protein 3 JBrowse link 13 69,135,095 69,197,708 RGD:6907045
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 JBrowse link 12 12,749,026 12,782,078 RGD:6907045
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 JBrowse link 6 1,428,845 1,466,193 RGD:6907045
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 JBrowse link 4 98,648,513 98,709,695 RGD:6907045
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 JBrowse link 3 110,159,624 110,245,382 RGD:6907045
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha JBrowse link 6 102,048,372 102,073,041 RGD:6907045
G Erlec1 endoplasmic reticulum lectin 1 JBrowse link 14 115,314,890 115,352,871 RGD:6907045
G Ern1 endoplasmic reticulum to nucleus signaling 1 JBrowse link 10 94,588,555 94,682,072 RGD:6907045
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha JBrowse link 15 19,619,947 19,655,381 RGD:6907045
G Ero1b endoplasmic reticulum oxidoreductase 1 beta JBrowse link 17 90,709,394 90,783,110 RGD:6907045
G Erp29 endoplasmic reticulum protein 29 JBrowse link 12 40,619,377 40,625,884 RGD:6907045
G Fbxo2 F-box protein 2 JBrowse link 5 164,972,483 164,977,912 RGD:6907045
G Fbxo6 F-box protein 6 JBrowse link 5 164,956,285 164,962,075 RGD:6907045
G Ganab glucosidase II alpha subunit JBrowse link 1 225,096,558 225,116,384 RGD:6907045
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 JBrowse link 19 11,046,905 11,057,440 RGD:6907045
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:6907045
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:6907045
G Hsp90b1 heat shock protein 90 beta family member 1 JBrowse link 7 27,226,570 27,240,533 RGD:6907045
G Hspa1a heat shock protein family A (Hsp70) member 1A JBrowse link 20 4,875,834 4,881,751 RGD:6907045
G Hspa1b heat shock protein family A (Hsp70) member 1B JBrowse link 20 4,877,638 4,880,112 RGD:6907045
G Hspa1l heat shock protein family A (Hsp70) member 1 like JBrowse link 20 4,879,998 4,965,191 RGD:6907045
G Hspa2 heat shock protein family A (Hsp70) member 2 JBrowse link 6 99,433,575 99,436,288 RGD:6907045
G Hspa4l heat shock protein family A (Hsp70) member 4 like JBrowse link 2 127,625,737 127,682,864 RGD:6907045
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:6907045
G Hspa8 heat shock protein family A (Hsp70) member 8 JBrowse link 8 44,989,401 44,993,261 RGD:6907045
G Hspbp1 HSPA (Hsp70) binding protein 1 JBrowse link 1 72,732,418 72,756,087 RGD:6907045
G Hsph1 heat shock protein family H (Hsp110) member 1 JBrowse link 12 6,322,685 6,341,898 RGD:6907045
G Hyou1 hypoxia up-regulated 1 JBrowse link 8 48,699,796 48,711,912 RGD:6907045
G Lman1 lectin, mannose-binding, 1 JBrowse link 18 61,683,377 61,707,344 RGD:6907045
G Lman1l lectin, mannose-binding, 1 like JBrowse link 8 62,386,806 62,400,370 RGD:6907045
G Lman2 lectin, mannose-binding 2 JBrowse link 17 9,798,136 9,815,820 RGD:6907045
G Man1a1 mannosidase, alpha, class 1A, member 1 JBrowse link 20 35,257,688 35,450,132 RGD:6907045
G Man1a2 mannosidase, alpha, class 1A, member 2 JBrowse link 2 202,891,537 203,043,847 RGD:6907045
G Man1b1 mannosidase, alpha, class 1B, member 1 JBrowse link 3 2,547,259 2,569,051 RGD:6907045
G Man1c1 mannosidase, alpha, class 1C, member 1 JBrowse link 5 152,775,031 152,920,130 RGD:6907045
G Map2k7 mitogen activated protein kinase kinase 7 JBrowse link 12 2,546,278 2,555,310 RGD:6907045
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:6907045
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6907045
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6907045
G Marchf6 membrane associated ring-CH-type finger 6 JBrowse link 2 84,533,546 84,608,743 RGD:6907045
G Mbtps1 membrane-bound transcription factor peptidase, site 1 JBrowse link 19 52,146,507 52,206,310 RGD:6907045
G Mbtps2 membrane-bound transcription factor peptidase, site 2 JBrowse link X 40,258,933 40,309,047 RGD:6907045
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6907045
G Ngly1 N-glycanase 1 JBrowse link 15 10,405,453 10,455,973 RGD:6907045
G Nploc4 NPL4 homolog, ubiquitin recognition factor JBrowse link 10 109,553,518 109,610,087 RGD:6907045
G Nsfl1c NSFL1 cofactor JBrowse link 3 146,980,923 147,005,478 RGD:6907045
G Os9 OS9, endoplasmic reticulum lectin JBrowse link 7 70,378,625 70,407,135 RGD:6907045
G P4hb prolyl 4-hydroxylase subunit beta JBrowse link 10 109,736,459 109,748,070 RGD:6907045
G Pdia3 protein disulfide isomerase family A, member 3 JBrowse link 3 113,376,983 113,400,707 RGD:6907045
G Pdia4 protein disulfide isomerase family A, member 4 JBrowse link 4 77,470,636 77,489,535 RGD:6907045
G Pdia6 protein disulfide isomerase family A, member 6 JBrowse link 6 42,568,269 42,585,654 RGD:6907045
G Plaa phospholipase A2, activating protein JBrowse link 5 113,548,913 113,578,928 RGD:6907045
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A JBrowse link 1 101,511,899 101,515,043 RGD:6907045
G Preb prolactin regulatory element binding JBrowse link 6 26,784,088 26,787,875 RGD:6907045
G Prkcsh protein kinase C substrate 80K-H JBrowse link 8 23,014,802 23,026,507 RGD:6907045
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:6907045
G Rad23a RAD23 homolog A, nucleotide excision repair protein JBrowse link 19 25,949,488 25,956,677 RGD:6907045
G Rad23b RAD23 homolog B, nucleotide excision repair protein JBrowse link 5 72,103,704 72,141,701 RGD:6907045
G Rbx1 ring-box 1 JBrowse link 7 122,700,849 122,710,907 RGD:6907045
G Rnf5 ring finger protein 5 JBrowse link 20 4,366,244 4,368,690 RGD:6907045
G Rpn1 ribophorin I JBrowse link 4 119,997,232 120,018,687 RGD:6907045
G Rpn2 ribophorin II JBrowse link 3 153,398,373 153,445,633 RGD:6907045
G Rrbp1 ribosome binding protein 1 JBrowse link 3 138,054,938 138,116,858 RGD:6907045
G Sar1a secretion associated, Ras related GTPase 1A JBrowse link 20 31,298,269 31,310,676 RGD:6907045
G Sar1b secretion associated, Ras related GTPase 1B JBrowse link 10 37,215,989 37,245,603 RGD:6907045
G Sec13 SEC13 homolog, nuclear pore and COPII coat complex component JBrowse link 4 145,686,186 145,699,577 RGD:6907045
G Sec23a Sec23 homolog A, COPII coat complex component JBrowse link 6 80,059,742 80,107,340 RGD:6907045
G Sec24a SEC24 homolog A, COPII coat complex component JBrowse link 10 37,138,539 37,215,899 RGD:6907045
G Sec24b SEC24 homolog B, COPII coat complex component JBrowse link 2 230,286,886 230,356,887 RGD:6907045
G Sec24c SEC24 homolog C, COPII coat complex component JBrowse link 15 4,035,196 4,057,209 RGD:6907045
G Sec31a SEC31 homolog A, COPII coat complex component JBrowse link 14 10,854,713 10,909,579 RGD:6907045
G Sec31b SEC31 homolog B, COPII coat complex component JBrowse link 1 264,266,279 264,294,687 RGD:6907045
G Sec61a1 SEC61 translocon subunit alpha 1 JBrowse link 4 120,453,577 120,467,932 RGD:6907045
G Sec61a2 SEC61 translocon subunit alpha 2 JBrowse link 17 76,358,947 76,385,860 RGD:6907045
G Sec61b SEC61 translocon subunit beta JBrowse link 5 63,192,322 63,200,532 RGD:6907045
G Sec61g SEC61 translocon subunit gamma JBrowse link 14 99,774,589 99,780,964 RGD:6907045
G Sec62 SEC62 homolog, preprotein translocation factor JBrowse link 2 116,188,736 116,225,510 RGD:6907045
G Sec63 SEC63 homolog, protein translocation regulator JBrowse link 20 47,494,270 47,563,222 RGD:6907045
G Sel1l SEL1L adaptor subunit of ERAD E3 ubiquitin ligase JBrowse link 6 115,572,683 115,616,904 RGD:6907045
G Sil1 SIL1 nucleotide exchange factor JBrowse link 18 28,067,476 28,302,008 RGD:6907045
G Skp1 S-phase kinase-associated protein 1 JBrowse link 10 37,594,578 37,609,498 RGD:6907045
G Ssr1 signal sequence receptor subunit 1 JBrowse link 17 27,496,369 27,512,781 RGD:6907045
G Ssr2 signal sequence receptor subunit 2 JBrowse link 2 187,951,316 187,960,067 RGD:6907045
G Ssr3 signal sequence receptor subunit 3 JBrowse link 2 156,010,997 156,023,853 RGD:6907045
G Ssr4 signal sequence receptor subunit 4 JBrowse link X 156,995,763 156,999,702 RGD:6907045
G Stt3a STT3 oligosaccharyltransferase complex catalytic subunit A JBrowse link 8 39,204,218 39,243,751 RGD:6907045
G Stt3b STT3 oligosaccharyltransferase complex catalytic subunit B JBrowse link 8 123,303,910 123,370,729 RGD:6907045
G Stub1 STIP1 homology and U-box containing protein 1 JBrowse link 10 15,197,754 15,200,035 RGD:6907045
G Syvn1 synoviolin 1 JBrowse link 1 221,409,281 221,416,229 RGD:6907045
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:6907045
G Tram1 translocation associated membrane protein 1 JBrowse link 5 5,215,196 5,297,337 RGD:6907045
G Tusc3 tumor suppressor candidate 3 JBrowse link 16 56,248,125 56,396,491 RGD:6907045
G Ube2d1 ubiquitin-conjugating enzyme E2D 1 JBrowse link 20 18,547,370 18,580,291 RGD:6907045
G Ube2d2 ubiquitin-conjugating enzyme E2D 2 JBrowse link 18 28,561,957 28,603,335 RGD:6907045
G Ube2d3 ubiquitin-conjugating enzyme E2D 3 JBrowse link 2 240,626,198 240,655,874 RGD:6907045
G Ube2d4 ubiquitin-conjugating enzyme E2D 4 (putative) JBrowse link 14 2,933,097 2,934,571 RGD:6907045
G Ube2e2 ubiquitin-conjugating enzyme E2E 2 JBrowse link 15 7,402,210 7,928,320 RGD:6907045
G Ube2e3 ubiquitin-conjugating enzyme E2E 3 JBrowse link 3 65,815,076 65,876,256 RGD:6907045
G Ube2g1 ubiquitin-conjugating enzyme E2G 1 JBrowse link 10 59,173,268 59,254,458 RGD:6907045
G Ube2g2 ubiquitin-conjugating enzyme E2G 2 JBrowse link 20 11,700,089 11,721,823 RGD:6907045
G Ube2j1 ubiquitin-conjugating enzyme E2, J1 JBrowse link 5 48,274,387 48,292,699 RGD:6907045
G Ube2j2 ubiquitin-conjugating enzyme E2, J2 JBrowse link 5 173,372,659 173,387,084 RGD:6907045
G Ube4b ubiquitination factor E4B JBrowse link 5 166,156,033 166,259,069 RGD:6907045
G Ubqln1 ubiquilin 1 JBrowse link 17 6,840,441 6,878,842 RGD:6907045
G Ubqln2 ubiquilin 2 JBrowse link X 18,723,313 18,726,732 RGD:6907045
G Ubqln3 ubiquilin 3 JBrowse link 1 169,331,457 169,334,120 RGD:6907045
G Ubqln4 ubiquilin 4 JBrowse link 2 187,915,701 187,931,035 RGD:6907045
G Ubqlnl ubiquilin-like JBrowse link 1 169,342,005 169,344,254 RGD:6907045
G Ubxn6 UBX domain protein 6 JBrowse link 9 10,995,516 11,000,643 RGD:6907045
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 JBrowse link 11 86,304,836 86,328,478 RGD:6907045
G Uggt1 UDP-glucose glycoprotein glucosyltransferase 1 JBrowse link 9 42,692,156 42,805,680 RGD:6907045
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:6907045
G Wfs1 wolframin ER transmembrane glycoprotein JBrowse link 14 78,640,707 78,665,224 RGD:6907045
G Xbp1 X-box binding protein 1 JBrowse link 14 85,753,736 85,758,820 RGD:6907045
G Yod1 YOD1 deubiquitinase JBrowse link 13 47,441,296 47,443,013 RGD:6907045

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6016
    regulatory pathway 3823
      pathway pertinent to protein folding, sorting, modification, translocation and degradation 317
        protein degradation pathway 314
          Endoplasmic Reticulum-associated degradation pathway 153
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.