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ONTOLOGY REPORT - ANNOTATIONS


Term:Endoplasmic Reticulum-associated degradation pathway
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Accession:PW:0000638 term browser browse the term
Definition:In the endoplasmic reticulum correctly folded proteins are targeted for further export whereas misfolded proteins are retained and targeted for degradation.
Synonyms:related_synonym: ERAD pathway;   KEGG:04141


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Endoplasmic Reticulum-associated degradation pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Amfr autocrine motility factor receptor JBrowse link NW_004955433 14,172,871 14,205,484 RGD:9068941
G Atf4 activating transcription factor 4 JBrowse link NW_004955413 25,406,589 25,408,727 RGD:9068941
G Atf6 activating transcription factor 6 JBrowse link NW_004955462 14,352,956 14,553,299 RGD:9068941
G Atf6b activating transcription factor 6 beta JBrowse link NW_004955437 582,083 592,026 RGD:9068941
G Atxn3 ataxin 3 JBrowse link NW_004955438 14,405,415 14,443,457 RGD:9068941
G Bag1 BAG cochaperone 1 JBrowse link NW_004955472 2,394,317 2,405,199 RGD:9068941
G Bag2 BAG cochaperone 2 JBrowse link NW_004955502 2,984,233 2,994,457 RGD:9068941
G Bak1 BCL2 antagonist/killer 1 JBrowse link NW_004955437 2,036,415 2,041,997 RGD:9068941
G Bax BCL2 associated X, apoptosis regulator JBrowse link NW_004955559 1,695,960 1,700,246 RGD:9068941
G Bcap31 B cell receptor associated protein 31 JBrowse link NW_004955580 429,223 459,168 RGD:9068941
G Bcl2 BCL2 apoptosis regulator JBrowse link NW_004955402 46,911,125 47,084,214 RGD:9068941
G Calr calreticulin JBrowse link NW_004955415 31,985,147 31,989,372 RGD:9068941
G Canx calnexin JBrowse link NW_004955408 850,773 894,362 RGD:9068941
G Capn1 calpain 1 JBrowse link NW_004955422 20,006,448 20,026,984 RGD:9068941
G Capn2 calpain 2 JBrowse link NW_004955520 1,287,829 1,315,318 RGD:9068941
G Ckap4 cytoskeleton associated protein 4 JBrowse link NW_004955405 40,277,082 40,279,486 RGD:9068941
G Cryaa crystallin alpha A JBrowse link NW_004955407 38,880,088 38,892,946 RGD:9068941
G Cryab crystallin alpha B JBrowse link NW_004955412 13,626,018 13,629,495 RGD:9068941
G Cul1 cullin 1 JBrowse link NW_004955491 4,165,400 4,212,483 RGD:9068941
G Dad1 defender against cell death 1 JBrowse link NW_004955409 37,670,266 37,688,226 RGD:9068941
G Ddit3 DNA damage inducible transcript 3 JBrowse link NW_004955458 5,232,979 5,238,513 RGD:9068941
G Ddost dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit JBrowse link NW_004955452 1,186,733 1,195,691 RGD:9068941
G Derl1 derlin 1 JBrowse link NW_004955540 1,918,230 1,944,186 RGD:9068941
G Derl2 derlin 2 JBrowse link NW_004955467 10,824,922 10,837,408 RGD:9068941
G Derl3 derlin 3 JBrowse link NW_004955455 8,415,868 8,418,753 RGD:9068941
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 JBrowse link NW_004955472 2,604,002 2,618,033 RGD:9068941
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 JBrowse link NW_004955474 8,180,995 8,202,169 RGD:9068941
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 JBrowse link NW_004955415 33,098,503 33,102,125 RGD:9068941
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 JBrowse link NW_004955420 21,097,292 21,113,053 RGD:9068941
G Dnajb12 DnaJ heat shock protein family (Hsp40) member B12 JBrowse link NW_004955437 19,266,206 19,285,654 RGD:9068941
G Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 JBrowse link NW_004955453 14,147,286 14,154,396 RGD:9068941
G Dnajc1 DnaJ heat shock protein family (Hsp40) member C1 JBrowse link NW_004955429 6,806,456 6,987,579 RGD:9068941
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 JBrowse link NW_004955403 14,681,015 14,717,060 RGD:9068941
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 JBrowse link NW_004955404 14,361,540 14,412,533 RGD:9068941
G Dnajc5 DnaJ heat shock protein family (Hsp40) member C5 JBrowse link NW_004955528 317,891 366,299 RGD:9068941
G Dnajc5b DnaJ heat shock protein family (Hsp40) member C5 beta JBrowse link NW_004955444 13,069,490 13,162,053 RGD:9068941
G Dnajc5g DnaJ heat shock protein family (Hsp40) member C5 gamma JBrowse link NW_004955469 9,254,372 9,257,235 RGD:9068941
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 JBrowse link NW_004955421 8,196,631 8,225,561 RGD:9068941
G Edem2 ER degradation enhancing alpha-mannosidase like protein 2 JBrowse link NW_004955422 26,243,034 26,271,849 RGD:9068941
G Edem3 ER degradation enhancing alpha-mannosidase like protein 3 JBrowse link NW_004955406 23,329,400 23,401,282 RGD:9068941
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 JBrowse link NW_004955460 13,723,674 13,754,545 RGD:9068941
G Eif2ak2 eukaryotic translation initiation factor 2 alpha kinase 2 JBrowse link NW_004955441 4,908,318 4,944,343 RGD:9068941
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 JBrowse link NW_004955424 210,867 279,267 RGD:9068941
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 JBrowse link NW_004955416 6,897,897 7,005,602 RGD:9068941
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha JBrowse link NW_004955466 2,838,785 2,855,443 RGD:9068941
G Erlec1 endoplasmic reticulum lectin 1 JBrowse link NW_004955441 19,535,425 19,557,960 RGD:9068941
G Ern1 endoplasmic reticulum to nucleus signaling 1 JBrowse link NW_004955478 7,720,664 7,803,662 RGD:9068941
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha JBrowse link NW_004955409 10,495,892 10,533,383 RGD:9068941
G Ero1b endoplasmic reticulum oxidoreductase 1 beta JBrowse link NW_004955492 3,845,406 3,911,671 RGD:9068941
G Erp29 endoplasmic reticulum protein 29 JBrowse link NW_004955482 8,572,227 8,579,589 RGD:9068941
G Fbxo2 F-box protein 2 JBrowse link NW_004955486 2,212,001 2,217,260 RGD:9068941
G Fbxo6 F-box protein 6 JBrowse link NW_004955486 2,197,296 2,205,947 RGD:9068941
G Ganab glucosidase II alpha subunit JBrowse link NW_004955599 556,510 569,891 RGD:9068941
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 JBrowse link NW_004955433 14,609,275 14,621,774 RGD:9068941
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link NW_004955538 1,469,544 1,475,010 RGD:9068941
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link NW_004955437 9,872,649 9,878,459 RGD:9068941
G Hsp90b1 heat shock protein 90 beta family member 1 JBrowse link NW_004955405 38,629,691 38,645,202 RGD:9068941
G Hspa2 heat shock protein family A (Hsp70) member 2 JBrowse link NW_004955466 5,344,366 5,347,707 RGD:9068941
G Hspa4l heat shock protein family A (Hsp70) member 4 like JBrowse link NW_004955428 13,589,532 13,644,079 RGD:9068941
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link NW_004955419 3,055,420 3,060,208 RGD:9068941
G Hspa6 heat shock protein family A (Hsp70) member 6 JBrowse link NW_004955462 14,723,990 14,726,420 RGD:9068941
G Hspa8 heat shock protein family A (Hsp70) member 8 JBrowse link NW_004955412 23,863,513 23,867,984 RGD:9068941
G Hspbp1 HSPA (Hsp70) binding protein 1 JBrowse link NW_004955567 948,040 960,621 RGD:9068941
G Hsph1 heat shock protein family H (Hsp110) member 1 JBrowse link NW_004955431 14,680,364 14,706,182 RGD:9068941
G Hyou1 hypoxia up-regulated 1 JBrowse link NW_004955412 20,149,104 20,161,378 RGD:9068941
G Lman1 lectin, mannose binding 1 JBrowse link NW_004955402 43,465,556 43,495,789 RGD:9068941
G Lman1l lectin, mannose binding 1 like JBrowse link NW_004955450 3,111,004 3,123,266 RGD:9068941
G Lman2 lectin, mannose binding 2 JBrowse link NW_004955408 29,581,737 29,597,240 RGD:9068941
G Man1a1 mannosidase alpha class 1A member 1 JBrowse link NW_004955436 1,830,275 1,972,861 RGD:9068941
G Man1a2 mannosidase alpha class 1A member 2 JBrowse link NW_004955435 20,532,717 20,683,805 RGD:9068941
G Man1b1 mannosidase alpha class 1B member 1 JBrowse link NW_004955513 5,109,651 5,122,568 RGD:9068941
G Man1c1 mannosidase alpha class 1C member 1 JBrowse link NW_004955452 5,147,247 5,281,229 RGD:9068941
G Map2k7 mitogen-activated protein kinase kinase 7 JBrowse link NW_004955563 1,352,638 1,361,598 RGD:9068941
G Map3k5 mitogen-activated protein kinase kinase kinase 5 JBrowse link NW_004955439 162,499 376,919 RGD:9068941
G Mapk10 mitogen-activated protein kinase 10 JBrowse link NW_004955474 3,451,656 3,772,405 RGD:9068941
G Mapk8 mitogen-activated protein kinase 8 JBrowse link NW_004955556 1,593,552 1,705,543 RGD:9068941
G Mapk9 mitogen-activated protein kinase 9 JBrowse link NW_004955408 391,094 430,638 RGD:9068941
G Marchf6 membrane associated ring-CH-type finger 6 JBrowse link NW_004955426 228,807 278,888 RGD:9068941
G Mbtps1 membrane bound transcription factor peptidase, site 1 JBrowse link NW_004955564 176,230 226,555 RGD:9068941
G Mbtps2 membrane bound transcription factor peptidase, site 2 JBrowse link NW_004955509 2,185,054 2,222,497 RGD:9068941
G Mogs mannosyl-oligosaccharide glucosidase JBrowse link NW_004955424 11,317,605 11,321,192 RGD:9068941
G Nfe2l2 nuclear factor, erythroid 2 like 2 JBrowse link NW_004955403 19,510,122 19,536,428 RGD:9068941
G Ngly1 N-glycanase 1 JBrowse link NW_004955430 17,564,319 17,645,564 RGD:9068941
G Nploc4 NPL4 homolog, ubiquitin recognition factor JBrowse link NW_004955506 1,451,337 1,513,455 RGD:9068941
G Nsfl1c NSFL1 cofactor JBrowse link NW_004955596 648,978 673,586 RGD:9068941
G Os9 OS9 endoplasmic reticulum lectin JBrowse link NW_004955458 5,407,709 5,432,646 RGD:9068941
G P4hb prolyl 4-hydroxylase subunit beta JBrowse link NW_004955506 1,307,932 1,322,011 RGD:9068941
G Pdia3 protein disulfide isomerase family A member 3 JBrowse link NW_004955416 10,197,957 10,221,104 RGD:9068941
G Pdia4 protein disulfide isomerase family A member 4 JBrowse link NW_004955491 4,344,874 4,360,205 RGD:9068941
G Pdia6 protein disulfide isomerase family A member 6 JBrowse link NW_004955487 5,735,698 5,744,601 RGD:9068941
G Plaa phospholipase A2 activating protein JBrowse link NW_004955472 7,879,196 7,915,040 RGD:9068941
G Ppp1r15a protein phosphatase 1 regulatory subunit 15A JBrowse link NW_004955559 1,750,227 1,753,607 RGD:9068941
G Preb prolactin regulatory element binding JBrowse link NW_004955469 9,097,579 9,101,361 RGD:9068941
G Prkcsh protein kinase C substrate 80K-H JBrowse link NW_004955495 2,331,075 2,338,479 RGD:9068941
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link NW_004955439 18,664,230 19,953,358 RGD:9068941
G Rad23a RAD23 homolog A, nucleotide excision repair protein JBrowse link NW_004955415 31,991,478 31,997,277 RGD:9068941
G Rad23b RAD23 homolog B, nucleotide excision repair protein JBrowse link NW_004955419 19,428,415 19,473,181 RGD:9068941
G Rbx1 ring-box 1 JBrowse link NW_004955413 26,579,759 26,592,980 RGD:9068941
G Rnf5 ring finger protein 5 JBrowse link NW_004955437 643,133 645,528 RGD:9068941
G Rpn1 ribophorin I JBrowse link NW_004955429 15,204,848 15,231,547 RGD:9068941
G Rpn2 ribophorin II JBrowse link NW_004955422 24,497,288 24,550,439 RGD:9068941
G Rrbp1 ribosome binding protein 1 JBrowse link NW_004955415 26,601,707 26,634,747 RGD:9068941
G Sar1a secretion associated Ras related GTPase 1A JBrowse link NW_004955437 21,075,632 21,093,608 RGD:9068941
G Sar1b secretion associated Ras related GTPase 1B JBrowse link NW_004955408 5,737,197 5,761,228 RGD:9068941
G Sec13 SEC13 homolog, nuclear pore and COPII coat complex component JBrowse link NW_004955561 1,707,053 1,723,715 RGD:9068941
G Sec23a Sec23 homolog A, COPII coat complex component JBrowse link NW_004955409 22,192,549 22,243,090 RGD:9068941
G Sec23b SEC23 homolog B, COPII coat complex component JBrowse link NW_004955415 27,044,694 27,075,028 RGD:9068941
G Sec24a SEC24 homolog A, COPII coat complex component JBrowse link NW_004955408 5,803,438 5,850,879 RGD:9068941
G Sec24b SEC24 homolog B, COPII coat complex component JBrowse link NW_004955496 666,728 732,829 RGD:9068941
G Sec24c SEC24 homolog C, COPII coat complex component JBrowse link NW_004955437 18,132,969 18,161,167 RGD:9068941
G Sec24d SEC24 homolog D, COPII coat complex component JBrowse link NW_004955428 21,381,809 21,475,329 RGD:9068941
G Sec31a SEC31 homolog A, COPII coat complex component JBrowse link NW_004955433 6,830,732 6,891,259 RGD:9068941
G Sec31b SEC31 homolog B, COPII coat complex component JBrowse link NW_004955485 9,615,879 9,655,826 RGD:9068941
G Sec61a1 SEC61 translocon alpha 1 subunit JBrowse link NW_004955429 15,637,461 15,652,556 RGD:9068941
G Sec61a2 SEC61 translocon alpha 2 subunit JBrowse link NW_004955462 166,423 189,592 RGD:9068941
G Sec61b SEC61 translocon beta subunit JBrowse link NW_004955419 26,414,891 26,423,260 RGD:9068941
G Sec61g SEC61 translocon gamma subunit JBrowse link NW_004955456 645,607 651,764 RGD:9068941
G Sec62 SEC62 homolog, preprotein translocation factor JBrowse link NW_004955420 219,909 247,471 RGD:9068941
G Sec63 SEC63 homolog, protein translocation regulator JBrowse link NW_004955411 33,063,056 33,126,325 RGD:9068941
G Sel1l SEL1L adaptor subunit of ERAD E3 ubiquitin ligase JBrowse link NW_004955438 5,030,915 5,082,015 RGD:9068941
G Sil1 SIL1 nucleotide exchange factor JBrowse link NW_004955418 1,322,644 1,583,352 RGD:9068941
G Skp1 S-phase kinase associated protein 1 JBrowse link NW_004955408 5,393,851 5,412,644 RGD:9068941
G Ssr1 signal sequence receptor subunit 1 JBrowse link NW_004955465 6,540,509 6,557,402 RGD:9068941
G Ssr2 signal sequence receptor subunit 2 JBrowse link NW_004955545 2,205,906 2,213,780 RGD:9068941
G Ssr3 signal sequence receptor subunit 3 JBrowse link NW_004955448 7,554,303 7,569,022 RGD:9068941
G Ssr4 signal sequence receptor subunit 4 JBrowse link NW_004955580 507,672 511,498 RGD:9068941
G Stt3a STT3 oligosaccharyltransferase complex catalytic subunit A JBrowse link NW_004955412 26,593,142 26,624,143 RGD:9068941
G Stt3b STT3 oligosaccharyltransferase complex catalytic subunit B JBrowse link NW_004955430 22,986,673 23,070,923 RGD:9068941
G Stub1 STIP1 homology and U-box containing protein 1 JBrowse link NW_004955442 16,521,130 16,523,733 RGD:9068941
G Svip small VCP interacting protein JBrowse link NW_004955476 3,231,789 3,236,602 RGD:9068941
G Syvn1 synoviolin 1 JBrowse link NW_004955422 20,067,933 20,074,947 RGD:9068941
G Traf2 TNF receptor associated factor 2 JBrowse link NW_004955513 4,964,692 4,984,359 RGD:9068941
G Tram1 translocation associated membrane protein 1 JBrowse link NW_004955444 9,110,533 9,153,585 RGD:9068941
G Tusc3 tumor suppressor candidate 3 JBrowse link NW_004955463 1,633,776 1,848,187 RGD:9068941
G Txndc5 thioredoxin domain containing 5 JBrowse link NW_004955465 6,034,006 6,053,779 RGD:9068941
G Ube2d1 ubiquitin conjugating enzyme E2 D1 JBrowse link NW_004955425 12,073,267 12,090,613 RGD:9068941
G Ube2d2 ubiquitin conjugating enzyme E2 D2 JBrowse link NW_004955418 990,124 1,043,544 RGD:9068941
G Ube2d3 ubiquitin conjugating enzyme E2 D3 JBrowse link NW_004955496 5,694,471 5,727,003 RGD:9068941
G Ube2d4 ubiquitin conjugating enzyme E2 D4 (putative) JBrowse link NW_004955456 7,928,715 7,952,155 RGD:9068941
G Ube2e1 ubiquitin conjugating enzyme E2 E1 JBrowse link NW_004955430 15,648,736 15,734,767 RGD:9068941
G Ube2e2 ubiquitin conjugating enzyme E2 E2 JBrowse link NW_004955430 15,122,373 15,442,264 RGD:9068941
G Ube2e3 ubiquitin conjugating enzyme E2 E3 JBrowse link NW_004955403 16,151,629 16,239,855 RGD:9068941
G Ube2g1 ubiquitin conjugating enzyme E2 G1 JBrowse link NW_004955467 12,552,001 12,639,620 RGD:9068941
G Ube2g2 ubiquitin conjugating enzyme E2 G2 JBrowse link NW_004955407 41,683,771 41,724,014 RGD:9068941
G Ube2j1 ubiquitin conjugating enzyme E2 J1 JBrowse link NW_004955411 16,076,647 16,091,554 RGD:9068941
G Ube2j2 ubiquitin conjugating enzyme E2 J2 JBrowse link NW_004955486 9,519,467 9,539,666 RGD:9068941
G Ube4b ubiquitination factor E4B JBrowse link NW_004955486 3,518,873 3,626,036 RGD:9068941
G Ubqln1 ubiquilin 1 JBrowse link NW_004955432 3,575,034 3,617,029 RGD:9068941
G Ubqln2 ubiquilin 2 JBrowse link NW_004955475 3,260,209 3,263,586 RGD:9068941
G Ubqln3 ubiquilin 3 JBrowse link NW_004955414 21,404,600 21,406,520 RGD:9068941
G Ubqln4 ubiquilin 4 JBrowse link NW_004955545 2,218,794 2,236,665 RGD:9068941
G Ubqlnl ubiquilin like JBrowse link NW_004955414 21,420,663 21,422,968 RGD:9068941
G Ubxn6 UBX domain protein 6 JBrowse link NW_004955495 4,456,182 4,465,954 RGD:9068941
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 JBrowse link NW_004955442 18,548,545 18,568,989 RGD:9068941
G Uggt1 UDP-glucose glycoprotein glucosyltransferase 1 JBrowse link NW_004955459 2,347,946 2,461,174 RGD:9068941
G Uggt2 UDP-glucose glycoprotein glucosyltransferase 2 JBrowse link NW_004955404 14,165,686 14,354,207 RGD:9068941
G Vcp valosin containing protein JBrowse link NW_004955472 1,111,649 1,124,076 RGD:9068941
G Wfs1 wolframin ER transmembrane glycoprotein JBrowse link NW_004955514 3,902,508 3,924,281 RGD:9068941
G Xbp1 X-box binding protein 1 JBrowse link NW_004955455 3,037,885 3,041,827 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5435
    regulatory pathway 3344
      pathway pertinent to protein folding, sorting, modification, translocation and degradation 320
        protein degradation pathway 318
          Endoplasmic Reticulum-associated degradation pathway 159
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.