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Term:insulin responsive facilitative sugar transporter mediated glucose transport pathway
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Accession:PW:0000639 term browser browse the term
Definition:The GLUT family contains 14 members in mammals which can be grouped into 3 classes based on sequence similarities. The members of group I (best characterized) and of group III transporters facilitate glucose transport. Of the three members of group I, Slc2a4 (Glut4), is involved in insulin-mediated uptake of glucose in the heart, skeletal muscle and adipose tissue. The response - central to glucose homeostasis - brings together several signaling and trafficking events.
Synonyms:related_synonym: PID:200196

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insulin responsive facilitative sugar transporter mediated glucose transport pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACTR2 actin related protein 2 JBrowse link 3 76,691,275 76,729,269 RGD:9068941
G ACTR3 actin related protein 3 JBrowse link 15 20,104,808 20,171,721 RGD:9068941
G AKT1 AKT serine/threonine kinase 1 RGD:9068941
G AKT2 AKT serine/threonine kinase 2 JBrowse link 6 48,555,785 48,620,472 RGD:9068941
G ARPC1A actin related protein 2/3 complex subunit 1A JBrowse link 3 6,296,257 6,324,526 RGD:9068941
G ARPC1B actin related protein 2/3 complex subunit 1B JBrowse link 3 6,329,737 6,342,641 RGD:9068941
G ARPC2 actin related protein 2/3 complex subunit 2 JBrowse link 15 120,297,122 120,328,795 RGD:9068941
G ARPC3 actin related protein 2/3 complex subunit 3 JBrowse link 14 31,814,382 31,823,452 RGD:9068941
G ARPC4 actin related protein 2/3 complex subunit 4 JBrowse link 13 66,075,926 66,093,986 RGD:9068941
G ARPC5 actin related protein 2/3 complex subunit 5 JBrowse link 9 124,839,062 124,847,906 RGD:9068941
G ASIP agouti signaling protein JBrowse link 17 37,542,615 37,718,787 RGD:9068941
G BAIAP2 BAR/IMD domain containing adaptor protein 2 JBrowse link 12 1,609,420 1,666,965 RGD:9068941
G CALM1 calmodulin 1 JBrowse link 7 112,160,823 112,171,754 RGD:9068941
G CALM2 calmodulin 2 JBrowse link 3 93,371,765 93,386,378 RGD:9068941
G CALM3 calmodulin 3 JBrowse link 6 52,506,979 52,516,704 RGD:9068941
G CBL Cbl proto-oncogene JBrowse link 9 46,416,937 46,512,855 RGD:9068941
G CFL1 cofilin 1 JBrowse link 2 6,471,558 6,475,019 RGD:9068941
G CRK CRK proto-oncogene, adaptor protein JBrowse link 12 47,656,805 47,685,641 RGD:9068941
G CYFIP1 cytoplasmic FMR1 interacting protein 1 JBrowse link 15 32,064,431 32,175,095 RGD:9068941
G DENND1C DENN domain containing 1C JBrowse link 2 72,610,543 72,620,212 RGD:9068941
G DENND4A DENN domain containing 4A JBrowse link 1 163,661,448 163,790,264 RGD:9068941
G DENND4B DENN domain containing 4B JBrowse link 4 95,745,878 95,762,192 RGD:9068941
G DENND4C DENN domain containing 4C JBrowse link 1 203,449,832 203,601,298 RGD:9068941
G GSK3B glycogen synthase kinase 3 beta JBrowse link 13 140,136,109 140,370,197 RGD:9068941
G GYS1 glycogen synthase 1 JBrowse link 6 54,234,600 54,250,211 RGD:9068941
G INS insulin JBrowse link 2 1,496,842 1,498,052 RGD:9068941
G INSR insulin receptor JBrowse link 2 71,797,209 71,939,923 RGD:9068941
G IQGAP1 IQ motif containing GTPase activating protein 1 JBrowse link 7 53,020,479 53,129,964 RGD:9068941
G KIF3A kinesin family member 3A JBrowse link 2 134,932,339 135,069,408 RGD:9068941
G KIF5B kinesin family member 5B JBrowse link 10 42,637,105 42,693,551 RGD:9068941
G LIMK1 LIM domain kinase 1 JBrowse link 3 11,252,820 11,279,286 RGD:9068941
G LNPEP leucyl and cystinyl aminopeptidase JBrowse link 2 103,568,366 103,659,589 RGD:9068941
G MYO1C myosin IC JBrowse link 12 47,691,252 47,715,670 RGD:9068941
G MYO5A myosin VA JBrowse link 1 119,165,751 119,398,591 RGD:9068941
G MYO5B myosin VB JBrowse link 1 99,418,242 99,810,934 RGD:9068941
G PAK1 p21 (RAC1) activated kinase 1 JBrowse link 9 11,830,095 11,973,074 RGD:9068941
G PLEKHG4 pleckstrin homology and RhoGEF domain containing G4 JBrowse link 6 27,921,598 27,932,680 RGD:9068941
G PPP1CC protein phosphatase 1 catalytic subunit gamma JBrowse link 14 32,071,472 32,091,267 RGD:9068941
G PPP1R3A protein phosphatase 1 regulatory subunit 3A JBrowse link 18 31,997,667 32,039,949 RGD:9068941
G PREX1 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 JBrowse link 17 50,352,273 50,550,402 RGD:9068941
G PRKCI protein kinase C iota JBrowse link 13 108,913,018 108,997,934 RGD:9068941
G PRKCZ protein kinase C zeta JBrowse link 6 64,073,343 64,159,187 RGD:9068941
G RAB10 RAB10, member RAS oncogene family JBrowse link 3 112,842,190 112,924,188 RGD:9068941
G RAB11A RAB11A, member RAS oncogene family JBrowse link 1 163,858,254 163,887,741 RGD:9068941
G RAB13 RAB13, member RAS oncogene family JBrowse link 4 95,705,093 95,709,942 RGD:9068941
G RAB14 RAB14, member RAS oncogene family JBrowse link 1 261,228,112 261,256,913 RGD:9068941
G RAB2A RAB2A, member RAS oncogene family JBrowse link 4 72,800,617 72,882,183 RGD:9068941
G RAB3IP RAB3A interacting protein JBrowse link 5 34,002,792 34,053,893 RGD:9068941
G RAB4A RAB4A, member RAS oncogene family JBrowse link 14 60,481,484 60,528,549 RGD:9068941
G RAB5A RAB5A, member RAS oncogene family JBrowse link 13 6,905,302 6,940,165 RGD:9068941
G RAB8A RAB8A, member RAS oncogene family JBrowse link 2 61,430,680 61,450,351 RGD:9068941
G RAB8B RAB8B, member RAS oncogene family JBrowse link 1 108,772,851 108,840,222 RGD:9068941
G RAC1 Rac family small GTPase 1 JBrowse link 3 4,781,776 4,803,510 RGD:9068941
G RAPGEF1 Rap guanine nucleotide exchange factor 1 JBrowse link 1 271,494,243 271,624,609 RGD:9068941
G RHOQ ras homolog family member Q JBrowse link 3 93,970,545 94,012,660 RGD:9068941
G SLC2A4 solute carrier family 2 member 4 JBrowse link 12 52,628,746 52,634,965 RGD:9068941
G SNAP23 synaptosome associated protein 23 JBrowse link 1 128,849,465 128,888,972 RGD:9068941
G SORBS1 sorbin and SH3 domain containing 1 JBrowse link 14 106,895,764 107,137,469 RGD:9068941
G SSH1 slingshot protein phosphatase 1 JBrowse link 14 41,963,946 42,030,842 RGD:9068941
G STX4 syntaxin 4 JBrowse link 3 17,422,266 17,431,377 RGD:9068941
G STXBP3 syntaxin binding protein 3 JBrowse link 4 111,234,154 111,294,067 RGD:9068941
G STXBP4 syntaxin binding protein 4 JBrowse link 12 31,277,116 31,478,828 RGD:9068941
G TBC1D1 TBC1 domain family member 1 JBrowse link 8 29,370,344 29,590,574 RGD:9068941
G TBC1D4 TBC1 domain family member 4 JBrowse link 11 47,543,808 47,760,928 RGD:9068941
G TIAM1 TIAM Rac1 associated GEF 1 JBrowse link 13 194,774,495 195,235,750 RGD:9068941
G TRIP10 thyroid hormone receptor interactor 10 JBrowse link 2 72,406,500 72,416,146 RGD:9068941
G VAMP2 vesicle associated membrane protein 2 JBrowse link 12 53,378,407 53,382,243 RGD:9068941
G YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta JBrowse link 17 47,298,020 47,317,826 RGD:9068941
G YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon JBrowse link 12 47,601,133 47,645,327 RGD:9068941
G YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma JBrowse link 3 9,994,802 10,023,296 RGD:9068941
G YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta JBrowse link 14 48,544,031 48,556,496 RGD:9068941
G YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta JBrowse link 3 126,738,795 126,772,784 RGD:9068941
G YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta JBrowse link 4 35,975,513 36,009,909 RGD:9068941
altered insulin responsive facilitative sugar transporter mediated glucose transport pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AKT2 AKT serine/threonine kinase 2 JBrowse link 6 48,555,785 48,620,472 RGD:9068941
G TBC1D4 TBC1 domain family member 4 JBrowse link 11 47,543,808 47,760,928 RGD:9068941

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Path 1
Term Annotations click to browse term
  pathway 5631
    regulatory pathway 3437
      transport pathway 344
        sugar transport pathway 78
          glucose transport pathway 78
            facilitative sugar transporter mediated glucose transport pathway 76
              insulin responsive facilitative sugar transporter mediated glucose transport pathway 73
                altered insulin responsive facilitative sugar transporter mediated glucose transport pathway 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.