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Term:non-small cell lung carcinoma pathway
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Accession:PW:0000705 term browser browse the term
Definition:Non-small cell lung carcinoma groups together several non-small cell lung carcinomas. The main types are represented by squamous cell, adeno- and large-cell carcinoma. Alterations in Ras and epidermal growth factor signaling, among others, have been implicated in the condition.
Synonyms:exact_synonym: non-small cell lung cancer pathway
 related_synonym: KEGG:05223;   NSCLC pathway;   non-small cell lung neoplasm pathway

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non-small cell lung carcinoma pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G R Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:5133243
RGD:6907045
G M Akt1 thymoma viral proto-oncogene 1 JBrowse link 12 112,653,821 112,674,884 RGD:5133243
RGD:6907045
G H AKT1 AKT serine/threonine kinase 1 JBrowse link 14 104,769,349 104,795,748 RGD:5133243
RGD:6907045
G R Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
G M Akt2 thymoma viral proto-oncogene 2 JBrowse link 7 27,591,552 27,640,826 RGD:6907045
G H AKT2 AKT serine/threonine kinase 2 JBrowse link 19 40,230,317 40,285,531 RGD:6907045
G R Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G M Akt3 thymoma viral proto-oncogene 3 JBrowse link 1 177,020,076 177,261,781 RGD:6907045
G H AKT3 AKT serine/threonine kinase 3 JBrowse link 1 243,488,233 243,851,079 RGD:6907045
G M Araf Araf proto-oncogene, serine/threonine kinase JBrowse link X 20,797,707 20,860,521 RGD:6907045
G H ARAF A-Raf proto-oncogene, serine/threonine kinase JBrowse link X 47,561,100 47,571,921 RGD:6907045
G R Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6907045
G M Bad BCL2-associated agonist of cell death JBrowse link 19 6,941,861 6,951,905 RGD:6907045
G H BAD BCL2 associated agonist of cell death JBrowse link 11 64,269,828 64,284,704 RGD:6907045
G R Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:5133242
RGD:6907045
RGD:5133243
G M Braf Braf transforming gene JBrowse link 6 39,603,231 39,725,658 RGD:5133242
RGD:6907045
RGD:5133243
G H BRAF B-Raf proto-oncogene, serine/threonine kinase JBrowse link 7 140,713,328 140,924,929 RGD:5133242
RGD:6907045
RGD:5133243
G R Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6907045
G M Casp9 caspase 9 JBrowse link 4 141,793,612 141,815,978 RGD:6907045
G H CASP9 caspase 9 JBrowse link 1 15,491,401 15,524,912 RGD:6907045
G R Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6907045
G M Ccnd1 cyclin D1 JBrowse link 7 144,929,931 144,939,831 RGD:6907045
G H CCND1 cyclin D1 JBrowse link 11 69,641,156 69,654,474 RGD:6907045
G R Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:6907045
G M Cdk4 cyclin-dependent kinase 4 JBrowse link 10 127,063,535 127,067,288 RGD:6907045
G H CDK4 cyclin dependent kinase 4 JBrowse link 12 57,747,727 57,752,310 RGD:6907045
G R Cdk6 cyclin-dependent kinase 6 JBrowse link 4 27,781,728 27,969,653 RGD:6907045
G M Cdk6 cyclin-dependent kinase 6 JBrowse link 5 3,341,004 3,531,008 RGD:6907045
G H CDK6 cyclin dependent kinase 6 JBrowse link 7 92,604,921 92,836,573 RGD:6907045
G R Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:6907045
G M Cdkn2a cyclin dependent kinase inhibitor 2A JBrowse link 4 89,274,473 89,294,619 RGD:6907045
G H CDKN2A cyclin dependent kinase inhibitor 2A JBrowse link 9 21,967,752 21,995,324 RGD:6907045
G R E2f1 E2F transcription factor 1 JBrowse link 3 150,062,895 150,073,721 RGD:6907045
G M E2f1 E2F transcription factor 1 JBrowse link 2 154,559,400 154,569,892 RGD:6907045
G H E2F1 E2F transcription factor 1 JBrowse link 20 33,675,477 33,686,385 RGD:6907045
G M E2f2 E2F transcription factor 2 JBrowse link 4 136,172,274 136,196,057 RGD:6907045
G H E2F2 E2F transcription factor 2 JBrowse link 1 23,505,696 23,531,250 RGD:6907045
G R E2f3 E2F transcription factor 3 JBrowse link 17 36,334,136 36,408,831 RGD:6907045
G M E2f3 E2F transcription factor 3 JBrowse link 13 29,906,575 29,986,064 RGD:6907045
G H E2F3 E2F transcription factor 3 JBrowse link 6 20,401,879 20,493,714 RGD:6907045
G R Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6907045
G M Egf epidermal growth factor JBrowse link 3 129,677,574 129,755,322 RGD:6907045
G H EGF epidermal growth factor JBrowse link 4 109,912,883 110,013,766 RGD:6907045
G R Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:5133241
RGD:6907045
RGD:5133242
G M Egfr epidermal growth factor receptor JBrowse link 11 16,752,203 16,913,907 RGD:5133241
RGD:6907045
RGD:5133242
G H EGFR epidermal growth factor receptor JBrowse link 7 55,019,017 55,211,628 RGD:5133241
RGD:6907045
RGD:5133242
G R Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:5133243
RGD:6907045
G M Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 11 98,412,484 98,437,716 RGD:5133243
RGD:6907045
G H ERBB2 erb-b2 receptor tyrosine kinase 2 JBrowse link 17 39,688,094 39,728,660 RGD:5133243
RGD:6907045
G R Fhit fragile histidine triad diadenosine triphosphatase JBrowse link 15 15,697,292 16,862,873 RGD:6907045
G M Fhit fragile histidine triad gene JBrowse link 14 9,550,092 11,162,061 RGD:6907045
G H FHIT fragile histidine triad diadenosine triphosphatase JBrowse link 3 59,747,277 61,251,461 RGD:6907045
G R Foxo3 forkhead box O3 JBrowse link 20 46,428,078 46,519,156 RGD:6907045
G M Foxo3 forkhead box O3 JBrowse link 10 42,181,845 42,276,695 RGD:6907045
G H FOXO3 forkhead box O3 JBrowse link 6 108,559,825 108,684,774 RGD:6907045
G R Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:6907045
G M Grb2 growth factor receptor bound protein 2 JBrowse link 11 115,644,045 115,708,597 RGD:6907045
G H GRB2 growth factor receptor bound protein 2 JBrowse link 17 75,318,076 75,405,709 RGD:6907045
G R Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6907045
G M Hras Harvey rat sarcoma virus oncogene JBrowse link 7 141,189,934 141,194,019 RGD:6907045
G H HRAS HRas proto-oncogene, GTPase JBrowse link 11 532,242 535,576 RGD:6907045
G R Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:5133242
RGD:6907045
G M Kras Kirsten rat sarcoma viral oncogene homolog JBrowse link 6 145,216,699 145,250,420 RGD:5133242
RGD:6907045
G H KRAS KRAS proto-oncogene, GTPase JBrowse link 12 25,205,246 25,250,929 RGD:5133242
RGD:6907045
G R Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:5133242
RGD:6907045
RGD:5133243
G M Map2k1 mitogen-activated protein kinase kinase 1 JBrowse link 9 64,185,769 64,253,605 RGD:5133242
RGD:6907045
RGD:5133243
G H MAP2K1 mitogen-activated protein kinase kinase 1 JBrowse link 15 66,386,912 66,491,544 RGD:5133242
RGD:6907045
RGD:5133243
G R Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6907045
G M Map2k2 mitogen-activated protein kinase kinase 2 JBrowse link 10 81,105,913 81,124,697 RGD:6907045
G H MAP2K2 mitogen-activated protein kinase kinase 2 JBrowse link 19 4,090,321 4,124,184 RGD:6907045
G R Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G M Mapk1 mitogen-activated protein kinase 1 JBrowse link 16 16,983,382 17,047,453 RGD:6907045
G H MAPK1 mitogen-activated protein kinase 1 JBrowse link 22 21,759,657 21,867,680 RGD:6907045
G R Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G M Mapk3 mitogen-activated protein kinase 3 JBrowse link 7 126,759,626 126,765,816 RGD:6907045
G H MAPK3 mitogen-activated protein kinase 3 JBrowse link 16 30,114,105 30,123,309 RGD:6907045
G R Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:5133241
RGD:5133243
RGD:5133242
G M Met met proto-oncogene JBrowse link 6 17,463,349 17,573,980 RGD:5133241
RGD:5133243
RGD:5133242
G H MET MET proto-oncogene, receptor tyrosine kinase JBrowse link 7 116,672,196 116,798,386 RGD:5133241
RGD:5133243
RGD:5133242
G R Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:6907045
G M Nras neuroblastoma ras oncogene JBrowse link 3 103,058,285 103,067,914 RGD:6907045
G H NRAS NRAS proto-oncogene, GTPase JBrowse link 1 114,704,469 114,716,771 RGD:6907045
G R Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6907045
G M Pdpk1 3-phosphoinositide dependent protein kinase 1 JBrowse link 17 24,073,680 24,155,619 RGD:6907045
G H PDPK1 3-phosphoinositide dependent protein kinase 1 JBrowse link 16 2,538,014 2,603,190 RGD:6907045
G R Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:5133242
RGD:6907045
RGD:5133243
G M Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link 3 32,397,065 32,466,112 RGD:5133242
RGD:6907045
RGD:5133243
G H PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link 3 179,148,114 179,240,093 RGD:5133242
RGD:6907045
RGD:5133243
G R Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G M Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta JBrowse link 9 99,038,402 99,140,235 RGD:6907045
G H PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta JBrowse link 3 138,652,698 138,834,928 RGD:6907045
G R Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G M Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta JBrowse link 4 149,649,168 149,702,566 RGD:6907045
G H PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta JBrowse link 1 9,629,889 9,729,114 RGD:6907045
G M Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma JBrowse link 12 32,173,397 32,208,677 RGD:6907045
G H PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma JBrowse link 7 106,865,282 106,908,980 RGD:6907045
G R Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G M Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 13 101,680,761 101,768,217 RGD:6907045
G H PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 5 68,215,737 68,301,821 RGD:6907045
G R Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G M Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 8 70,768,176 70,776,712 RGD:6907045
G H PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 19 18,153,163 18,170,532 RGD:6907045
G R Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G M Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 4 116,221,400 116,303,056 RGD:6907045
G H PIK3R3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 1 46,040,140 46,174,901 RGD:6907045
G R Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G M Pik3r5 phosphoinositide-3-kinase regulatory subunit 5 JBrowse link 11 68,432,125 68,497,849 RGD:6907045
G H PIK3R5 phosphoinositide-3-kinase regulatory subunit 5 JBrowse link 17 8,878,916 8,965,712 RGD:6907045
G R Plcg1 phospholipase C, gamma 1 JBrowse link 3 156,727,642 156,758,307 RGD:6907045
G M Plcg1 phospholipase C, gamma 1 JBrowse link 2 160,731,310 160,775,760 RGD:6907045
G H PLCG1 phospholipase C gamma 1 JBrowse link 20 41,137,519 41,177,626 RGD:6907045
G R Plcg2 phospholipase C, gamma 2 JBrowse link 19 50,039,410 50,173,543 RGD:6907045
G M Plcg2 phospholipase C, gamma 2 JBrowse link 8 117,498,275 117,635,142 RGD:6907045
G H PLCG2 phospholipase C gamma 2 JBrowse link 16 81,779,291 81,962,685 RGD:6907045
G R Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:6907045
G M Prkca protein kinase C, alpha JBrowse link 11 107,933,387 108,343,888 RGD:6907045
G H PRKCA protein kinase C alpha JBrowse link 17 66,302,613 66,810,743 RGD:6907045
G R Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:6907045
G M Prkcb protein kinase C, beta JBrowse link 7 122,289,104 122,634,402 RGD:6907045
G H PRKCB protein kinase C beta JBrowse link 16 23,835,983 24,220,611 RGD:6907045
G R Prkcg protein kinase C, gamma JBrowse link 1 64,407,098 64,433,698 RGD:6907045
G H PRKCG protein kinase C gamma JBrowse link 19 53,882,197 53,907,652 RGD:6907045
G R Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:5133242
G M Pten phosphatase and tensin homolog JBrowse link 19 32,757,577 32,826,160 RGD:5133242
G H PTEN phosphatase and tensin homolog JBrowse link 10 87,863,625 87,971,930 RGD:5133242
G R Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045
G M Raf1 v-raf-leukemia viral oncogene 1 JBrowse link 6 115,618,569 115,676,635 RGD:6907045
G H RAF1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 3 12,583,601 12,664,117 RGD:6907045
G R Rarb retinoic acid receptor, beta JBrowse link 15 9,915,223 10,262,599 RGD:6907045
G M Rarb retinoic acid receptor, beta JBrowse link 14 16,430,839 17,082,331 RGD:6907045
G H RARB retinoic acid receptor beta JBrowse link 3 24,829,323 25,597,932 RGD:6907045
G R Rassf1 Ras association domain family member 1 JBrowse link 8 116,307,149 116,318,289 RGD:6907045
G M Rassf1 Ras association (RalGDS/AF-6) domain family member 1 JBrowse link 9 107,551,434 107,562,267 RGD:6907045
G H RASSF1 Ras association domain family member 1 JBrowse link 3 50,329,786 50,340,936 RGD:6907045
G R Rassf5 Ras association domain family member 5 JBrowse link 13 47,956,754 48,022,333 RGD:6907045
G M Rassf5 Ras association (RalGDS/AF-6) domain family member 5 JBrowse link 1 131,176,410 131,245,178 RGD:6907045
G H RASSF5 Ras association domain family member 5 JBrowse link 1 206,507,531 206,589,448 RGD:6907045
G R Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6907045
G M Rb1 RB transcriptional corepressor 1 JBrowse link 14 73,192,858 73,325,951 RGD:6907045
G H RB1 RB transcriptional corepressor 1 JBrowse link 13 48,303,751 48,481,890 RGD:6907045
G R Rxra retinoid X receptor alpha JBrowse link 3 6,272,560 6,295,354 RGD:6907045
G M Rxra retinoid X receptor alpha JBrowse link 2 27,676,445 27,763,319 RGD:6907045
G H RXRA retinoid X receptor alpha JBrowse link 9 134,326,455 134,440,586 RGD:6907045
G R Rxrb retinoid X receptor beta JBrowse link 20 3,822,673 3,829,138 RGD:6907045
G M Rxrb retinoid X receptor beta JBrowse link 17 34,031,812 34,038,403 RGD:6907045
G H RXRB retinoid X receptor beta JBrowse link 6 33,193,585 33,200,991 RGD:6907045
G R Rxrg retinoid X receptor gamma JBrowse link 13 85,818,473 85,868,555 RGD:6907045
G M Rxrg retinoid X receptor gamma JBrowse link 1 167,598,362 167,639,623 RGD:6907045
G H RXRG retinoid X receptor gamma JBrowse link 1 165,400,922 165,445,355 RGD:6907045
G R Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:6907045
G M Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 17 80,393,752 80,480,453 RGD:6907045
G H SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 2 38,981,549 39,124,868 RGD:6907045
G R Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:6907045
G M Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 12 69,583,761 69,681,852 RGD:6907045
G H SOS2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 14 50,117,130 50,231,578 RGD:6907045
G R Stk4 serine/threonine kinase 4 JBrowse link 3 160,467,552 160,546,540 RGD:6907045
G M Stk4 serine/threonine kinase 4 JBrowse link 2 164,074,113 164,155,524 RGD:6907045
G H STK4 serine/threonine kinase 4 JBrowse link 20 44,966,470 45,080,021 RGD:6907045
G R Tgfa transforming growth factor alpha JBrowse link 4 117,961,877 118,045,923 RGD:6907045
G M Tgfa transforming growth factor alpha JBrowse link 6 86,195,038 86,275,744 RGD:6907045
G H TGFA transforming growth factor alpha JBrowse link 2 70,447,284 70,553,826 RGD:6907045
G R Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:5133242
RGD:6907045
G H TP53 tumor protein p53 JBrowse link 17 7,668,402 7,687,550 RGD:5133242
RGD:6907045
G M Trp53 transformation related protein 53 JBrowse link 11 69,580,348 69,591,873 RGD:5133242
RGD:6907045

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 29473
    disease pathway 9151
      cancer pathway 1234
        thoracic cancer pathway 334
          respiratory tract cancer pathway 334
            lung cancer pathway 334
              non-small cell lung carcinoma pathway 164
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.