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ONTOLOGY REPORT - ANNOTATIONS


Term:acute myeloid leukemia pathway
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Accession:PW:0000709 term browser browse the term
Definition:Acute myeloid leukemia is a common type of leukemia among adults. Abnormal cells are present inside the bone marrow that grow very vast and replace healthy blood cells. Several signaling pathways are disrupted and/or constitutively activated.
Synonyms:related_synonym: KEGG:05221


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acute myeloid leukemia pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AKT1 AKT serine/threonine kinase 1 RGD:9068941
G AKT2 AKT serine/threonine kinase 2 JBrowse link 6 48,555,785 48,620,472 RGD:9068941
G AKT3 AKT serine/threonine kinase 3 JBrowse link 10 16,441,465 16,741,745 RGD:9068941
G ARAF A-Raf proto-oncogene, serine/threonine kinase JBrowse link X 42,078,202 42,090,250 RGD:9068941
G BAD BCL2 associated agonist of cell death JBrowse link 2 7,831,192 7,842,864 RGD:9068941
G BRAF B-Raf proto-oncogene, serine/threonine kinase JBrowse link 18 8,957,963 9,132,558 RGD:9068941
G CCNA1 cyclin A1 JBrowse link 11 12,396,149 12,405,357 RGD:9068941
G CCND1 cyclin D1 JBrowse link 2 3,621,242 3,633,380 RGD:9068941
G CEBPA CCAAT enhancer binding protein alpha JBrowse link 6 43,083,200 43,085,884 RGD:9068941
G CHUK component of inhibitor of nuclear factor kappa B kinase complex JBrowse link 14 111,316,178 111,351,669 RGD:9068941
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 JBrowse link 15 48,423,001 48,443,373 RGD:9068941
G FLT3 fms related tyrosine kinase 3 JBrowse link 11 5,370,475 5,455,439 RGD:9068941
G GRB2 growth factor receptor bound protein 2 JBrowse link 12 5,940,723 6,009,095 RGD:9068941
G HRAS HRas proto-oncogene, GTPase JBrowse link 2 299,662 302,539 RGD:9068941
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 17 11,289,607 11,348,557 RGD:9068941
G IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma JBrowse link X 125,035,575 125,056,445 RGD:9068941
G JUP junction plakoglobin JBrowse link 12 20,902,395 20,931,208 RGD:9068941
G KIT KIT proto-oncogene, receptor tyrosine kinase JBrowse link 8 41,402,334 41,492,306 RGD:9068941
G KRAS KRAS proto-oncogene, GTPase JBrowse link 5 48,508,774 48,546,260 RGD:9068941
G LEF1 lymphoid enhancer binding factor 1 JBrowse link 8 113,824,511 113,944,078 RGD:9068941
G LOC100511937 phosphatidylinositol 3-kinase regulatory subunit gamma JBrowse link 6 165,268,260 165,402,668 RGD:9068941
G MAP2K1 mitogen-activated protein kinase kinase 1 JBrowse link 1 164,381,892 164,469,313 RGD:9068941
G MAP2K2 mitogen-activated protein kinase kinase 2 JBrowse link 2 74,626,739 74,651,352 RGD:9068941
G MAPK1 mitogen-activated protein kinase 1 JBrowse link 14 50,083,079 50,165,528 RGD:9068941
G MAPK3 mitogen-activated protein kinase 3 JBrowse link 3 18,291,444 18,299,410 RGD:9068941
G MTOR mechanistic target of rapamycin kinase JBrowse link 6 71,286,989 71,412,913 RGD:9068941
G MYC MYC proto-oncogene, bHLH transcription factor JBrowse link 4 12,455,141 12,460,360 RGD:9068941
G NFKB1 nuclear factor kappa B subunit 1 JBrowse link 8 118,391,010 118,478,927 RGD:9068941
G NRAS NRAS proto-oncogene, GTPase JBrowse link 4 105,845,913 105,853,769 RGD:9068941
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link 13 117,193,935 117,282,151 RGD:9068941
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta JBrowse link 13 79,427,033 79,610,840 RGD:9068941
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta JBrowse link 6 70,026,254 70,086,950 RGD:9068941
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma JBrowse link 9 106,698,200 106,748,217 RGD:9068941
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 16 46,434,757 46,523,626 RGD:9068941
G PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 2 59,637,363 59,652,075 RGD:9068941
G PIK3R5 phosphoinositide-3-kinase regulatory subunit 5 JBrowse link 12 53,979,206 54,046,927 RGD:9068941
G PIM1 Pim-1 proto-oncogene, serine/threonine kinase JBrowse link 7 32,788,246 32,793,882 RGD:9068941
G PIM2 Pim-2 proto-oncogene, serine/threonine kinase JBrowse link X 42,993,547 42,998,575 RGD:9068941
G PML promyelocytic leukemia JBrowse link 7 59,405,044 59,450,155 RGD:9068941
G PPARD peroxisome proliferator activated receptor delta JBrowse link 7 31,222,533 31,295,221 RGD:9068941
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 13 68,581,128 68,657,911 RGD:9068941
G RARA retinoic acid receptor alpha JBrowse link 12 22,047,449 22,085,759 RGD:9068941
G RELA RELA proto-oncogene, NF-kB subunit JBrowse link 2 6,594,869 6,602,684 RGD:9068941
G RPS6KB1 ribosomal protein S6 kinase B1 JBrowse link 12 36,111,584 36,159,287 RGD:9068941
G RPS6KB2 ribosomal protein S6 kinase B2 JBrowse link 2 5,089,466 5,095,591 RGD:9068941
G RUNX1 RUNX family transcription factor 1 JBrowse link 13 198,371,835 198,635,648 RGD:9068941
G RUNX1T1 RUNX1 partner transcriptional co-repressor 1 JBrowse link 4 44,600,292 44,745,954 RGD:9068941
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 3 101,209,568 101,366,057 RGD:9068941
G SOS2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 1 179,907,578 180,014,941 RGD:9068941
G SPI1 Spi-1 proto-oncogene JBrowse link 2 15,227,850 15,245,679 RGD:9068941
G STAT3 signal transducer and activator of transcription 3 JBrowse link 12 20,407,316 20,471,091 RGD:9068941
G STAT5A signal transducer and activator of transcription 5A JBrowse link 12 20,474,221 20,498,785 RGD:9068941
G STAT5B signal transducer and activator of transcription 5B JBrowse link 12 20,498,103 20,574,365 RGD:9068941
G TCF7 transcription factor 7 (T-cell specific, HMG-box) JBrowse link 2 136,422,740 136,456,323 RGD:9068941
G TCF7L1 transcription factor 7 like 1 JBrowse link 3 59,438,152 59,458,988 RGD:9068941
G TCF7L2 transcription factor 7 like 2 JBrowse link 14 123,343,695 123,547,332 RGD:9068941
G ZBTB16 zinc finger and BTB domain containing 16 JBrowse link 9 41,639,536 41,839,254 RGD:9068941

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  pathway 5629
    disease pathway 1907
      cancer pathway 384
        leukemia pathway 95
          myeloid leukemia pathway 95
            acute myeloid leukemia pathway 57
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.