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The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (

Term:warfarin pharmacodynamics pathway
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Accession:PW:0000731 term browser browse the term
Definition:The pathway of warfarin-target interaction and of the biochemical or physiological responses to drug. Warfarin is used as anticoagulant that antagonizes the vitamin K dependent clotting pathway. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00268

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warfarin pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COL1A1 collagen type I alpha 1 chain ISO SMPDB SMP:00268 NCBI chr17:44,274,349...44,291,764
Ensembl chr17:49,150,677...49,166,677
JBrowse link
G F10 coagulation factor X ISO SMPDB SMP:00268 NCBI chr13:94,263,202...94,289,612
Ensembl chr13:113,332,124...113,358,660
JBrowse link
G F11 coagulation factor XI ISO SMPDB SMP:00268 NCBI chr 4:178,436,865...178,459,568
Ensembl chr 4:190,643,733...190,666,512
JBrowse link
G F12 coagulation factor XII ISO SMPDB SMP:00268 NCBI chr 5:172,703,724...172,711,618
Ensembl chr 5:179,766,243...179,773,485
JBrowse link
G F13A1 coagulation factor XIII A chain ISO SMPDB SMP:00268 NCBI chr 6:5,978,505...6,156,705
Ensembl chr 6:6,157,926...6,513,961
JBrowse link
G F13B coagulation factor XIII B chain ISO SMPDB SMP:00268 NCBI chr 1:172,623,336...172,651,945
Ensembl chr 1:176,937,158...176,965,773
JBrowse link
G F2 coagulation factor II, thrombin ISO SMPDB SMP:00268 NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157
JBrowse link
G F3 coagulation factor III, tissue factor ISO SMPDB SMP:00268 NCBI chr 1:97,190,381...97,203,076
Ensembl chr 1:95,918,502...95,931,050
JBrowse link
G F5 coagulation factor V ISO SMPDB SMP:00268 NCBI chr 1:144,996,757...145,070,046
Ensembl chr 1:148,718,897...148,790,915
JBrowse link
G F7 coagulation factor VII ISO SMPDB SMP:00268 NCBI chr13:94,246,694...94,261,133
Ensembl chr13:113,315,868...113,329,995
JBrowse link
G F8 coagulation factor VIII ISO SMPDB SMP:00268 NCBI chr  X:144,316,192...144,505,773
Ensembl chr  X:154,156,873...154,341,317
JBrowse link
G F9 coagulation factor IX ISO SMPDB SMP:00268 NCBI chr  X:128,684,709...128,719,020
Ensembl chr  X:138,934,167...138,967,087
JBrowse link
G FGA fibrinogen alpha chain ISO SMPDB SMP:00268 NCBI chr 4:146,949,680...146,957,291 JBrowse link
G FGB fibrinogen beta chain ISO SMPDB SMP:00268 NCBI chr 4:146,929,561...146,937,665
Ensembl chr 4:158,747,659...158,755,766
JBrowse link
G FGG fibrinogen gamma chain ISO SMPDB SMP:00268 NCBI chr 4:146,970,671...146,979,348
Ensembl chr 4:158,788,966...158,797,237
JBrowse link
G GGCX gamma-glutamyl carboxylase ISO SMPDB SMP:00268 NCBI chr2A:85,599,227...85,612,274
Ensembl chr2A:87,152,111...87,164,567
JBrowse link
G KLKB1 kallikrein B1 ISO SMPDB SMP:00268 NCBI chr 4:178,398,359...178,429,448
Ensembl chr 4:190,604,901...190,636,300
JBrowse link
G LOC100982214 plasminogen ISO SMPDB SMP:00268 NCBI chr 6:158,662,192...158,713,413
Ensembl chr 6:163,673,464...163,736,777
JBrowse link
G PLAT plasminogen activator, tissue type ISO SMPDB SMP:00268 NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779
JBrowse link
G VKORC1 vitamin K epoxide reductase complex subunit 1 ISO SMPDB
PMID:26287237 RGD:11354881, SMP:00268 NCBI chr16:23,871,756...23,876,599
Ensembl chr16:31,459,560...31,464,897
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4036
    drug pathway 385
      blood and blood forming organs drug pathway 59
        antithrombotic drug pathway 59
          anticoagulant drug pathway 27
            vitamin K antagonist drug pathway 26
              warfarin drug pathway 26
                warfarin pharmacodynamics pathway 20
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.