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The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (

Term:warfarin pharmacodynamics pathway
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Accession:PW:0000731 term browser browse the term
Definition:The pathway of warfarin-target interaction and of the biochemical or physiological responses to drug. Warfarin is used as anticoagulant that antagonizes the vitamin K dependent clotting pathway. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00268

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warfarin pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COL1A1 collagen type I alpha 1 chain ISO SMPDB SMP:00268 NCBI chr 9:26,183,852...26,199,927
Ensembl chr 9:26,183,852...26,199,927
JBrowse link
G F10 coagulation factor X ISO SMPDB SMP:00268 NCBI chr22:60,585,563...60,597,027
Ensembl chr22:60,571,822...60,597,024
JBrowse link
G F11 coagulation factor XI ISO SMPDB SMP:00268 NCBI chr16:44,469,609...44,492,833
Ensembl chr16:44,469,632...44,540,292
JBrowse link
G F12 coagulation factor XII ISO SMPDB SMP:00268 NCBI chr 4:35,950,642...35,968,137
Ensembl chr 4:35,950,695...35,998,025
JBrowse link
G F13A1 coagulation factor XIII A chain ISO SMPDB SMP:00268 NCBI chr35:6,186,750...6,347,522
Ensembl chr35:6,187,235...6,349,773
JBrowse link
G F13B coagulation factor XIII B chain ISO SMPDB SMP:00268 NCBI chr 7:5,674,458...5,700,928
Ensembl chr 7:5,674,416...5,700,905
JBrowse link
G F2 coagulation factor II, thrombin ISO SMPDB SMP:00268 NCBI chr18:42,782,744...42,799,531
Ensembl chr18:42,782,751...42,799,459
JBrowse link
G F3 coagulation factor III, tissue factor ISO SMPDB SMP:00268 NCBI chr 6:54,709,581...54,720,603
Ensembl chr 6:54,708,471...54,720,607
JBrowse link
G F5 coagulation factor V ISO SMPDB SMP:00268 NCBI chr 7:28,999,481...29,069,603
Ensembl chr 7:28,999,512...29,069,296
JBrowse link
G F7 coagulation factor VII ISO SMPDB SMP:00268 NCBI chr22:60,572,459...60,582,743
Ensembl chr22:60,571,822...60,597,024
JBrowse link
G F8 coagulation factor VIII ISO SMPDB SMP:00268 NCBI chr  X:122,894,974...123,046,343
Ensembl chr  X:122,885,162...123,043,414
JBrowse link
G F9 coagulation factor IX ISO SMPDB SMP:00268 NCBI chr  X:109,501,341...109,533,798
Ensembl chr  X:109,501,341...109,533,798
JBrowse link
G FGA fibrinogen alpha chain ISO SMPDB SMP:00268 NCBI chr15:52,238,305...52,247,017
Ensembl chr15:52,236,198...52,246,975
JBrowse link
G FGB fibrinogen beta chain ISO SMPDB SMP:00268 NCBI chr15:52,220,690...52,228,526
Ensembl chr15:52,220,611...52,228,250
JBrowse link
G FGG fibrinogen gamma chain ISO SMPDB SMP:00268 NCBI chr15:52,261,215...52,270,077
Ensembl chr15:52,261,217...52,269,964
JBrowse link
G GGCX gamma-glutamyl carboxylase ISO SMPDB SMP:00268 NCBI chr17:39,512,293...39,525,251
Ensembl chr17:39,512,387...39,529,121
JBrowse link
G KLKB1 kallikrein B1 ISO SMPDB SMP:00268 NCBI chr16:44,492,735...44,517,854
Ensembl chr16:44,469,632...44,540,292
JBrowse link
G PLAT plasminogen activator, tissue type ISO SMPDB SMP:00268 NCBI chr16:23,469,590...23,496,013 JBrowse link
G PLG plasminogen ISO SMPDB SMP:00268 NCBI chr 1:49,497,229...49,535,260
Ensembl chr 1:49,497,229...49,535,260
JBrowse link
G VKORC1 vitamin K epoxide reductase complex subunit 1 ISO SMPDB
PMID:26287237 RGD:11354881, SMP:00268 NCBI chr 6:17,140,565...17,142,621
Ensembl chr 6:17,140,633...17,142,547
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4016
    drug pathway 374
      blood and blood forming organs drug pathway 56
        antithrombotic drug pathway 56
          anticoagulant drug pathway 25
            vitamin K antagonist drug pathway 24
              warfarin drug pathway 24
                warfarin pharmacodynamics pathway 20
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.