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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:warfarin pharmacodynamics pathway
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Accession:PW:0000731 term browser browse the term
Definition:The pathway of warfarin-target interaction and of the biochemical or physiological responses to drug. Warfarin is used as anticoagulant that antagonizes the vitamin K dependent clotting pathway. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00268

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warfarin pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COL1A1 collagen type I alpha 1 chain EXP SMPDB SMP:00268 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,183,289...50,201,632
Ensembl chr17:50,183,289...50,201,632
JBrowse link
G F10 coagulation factor X EXP SMPDB SMP:00268 NCBI chr13:113,122,799...113,149,529
Ensembl chr13:113,122,799...113,149,529
JBrowse link
G F11 coagulation factor XI EXP SMPDB SMP:00268 NCBI chr 4:186,265,964...186,290,727
Ensembl chr 4:186,266,189...186,289,681
Ensembl chr 4:186,266,189...186,289,681
JBrowse link
G F12 coagulation factor XII EXP SMPDB SMP:00268 NCBI chr 5:177,402,138...177,409,564
Ensembl chr 5:177,402,141...177,409,564
Ensembl chr 5:177,402,141...177,409,564
JBrowse link
G F13A1 coagulation factor XIII A chain EXP SMPDB SMP:00268 NCBI chr 6:6,144,084...6,320,662
Ensembl chr 6:6,144,084...6,321,013
Ensembl chr 6:6,144,084...6,321,013
JBrowse link
G F13B coagulation factor XIII B chain EXP SMPDB SMP:00268 NCBI chr 1:197,038,741...197,067,264
Ensembl chr 1:197,038,741...197,067,267
Ensembl chr 1:197,038,741...197,067,267
JBrowse link
G F2 coagulation factor II, thrombin EXP SMPDB SMP:00268 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506
Ensembl chr11:46,719,196...46,739,506
JBrowse link
G F3 coagulation factor III, tissue factor EXP SMPDB SMP:00268 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759
JBrowse link
G F5 coagulation factor V EXP SMPDB SMP:00268 NCBI chr 1:169,511,951...169,586,630
Ensembl chr 1:169,511,951...169,586,588
Ensembl chr 1:169,511,951...169,586,588
JBrowse link
G F7 coagulation factor VII EXP SMPDB SMP:00268 NCBI chr13:113,105,773...113,120,685
Ensembl chr13:113,105,788...113,120,681
Ensembl chr13:113,105,788...113,120,681
JBrowse link
G F8 coagulation factor VIII EXP SMPDB SMP:00268 NCBI chr  X:154,835,792...155,022,723
Ensembl chr  X:154,835,788...155,026,940
JBrowse link
G F9 coagulation factor IX EXP SMPDB SMP:00268 NCBI chr  X:139,530,720...139,563,459
Ensembl chr  X:139,530,739...139,563,459
Ensembl chr  X:139,530,739...139,563,459
JBrowse link
G FGA fibrinogen alpha chain EXP SMPDB SMP:00268 NCBI chr 4:154,583,126...154,590,742
Ensembl chr 4:154,583,128...154,590,745
JBrowse link
G FGB fibrinogen beta chain EXP SMPDB SMP:00268 NCBI chr 4:154,562,980...154,572,807
Ensembl chr 4:154,563,011...154,572,807
Ensembl chr 4:154,563,011...154,572,807
JBrowse link
G FGG fibrinogen gamma chain EXP SMPDB SMP:00268 NCBI chr 4:154,604,136...154,612,656
Ensembl chr 4:154,604,134...154,612,967
JBrowse link
G GGCX gamma-glutamyl carboxylase EXP SMPDB SMP:00268 NCBI chr 2:85,544,720...85,561,527
Ensembl chr 2:85,544,720...85,561,547
JBrowse link
G KLKB1 kallikrein B1 EXP SMPDB SMP:00268 NCBI chr 4:186,215,714...186,258,477
Ensembl chr 4:186,208,979...186,258,471
JBrowse link
G PLAT plasminogen activator, tissue type EXP SMPDB SMP:00268 NCBI chr 8:42,174,718...42,207,565
Ensembl chr 8:42,174,718...42,207,676
JBrowse link
G PLG plasminogen EXP SMPDB SMP:00268 NCBI chr 6:160,702,193...160,754,097
Ensembl chr 6:160,702,238...160,754,097
Ensembl chr 6:160,702,238...160,754,097
JBrowse link
G VKORC1 vitamin K epoxide reductase complex subunit 1 TAS
EXP
SMPDB PMID:26287237 SMP:00268, RGD:11354881 NCBI chr16:31,090,854...31,094,797
Ensembl chr16:31,090,842...31,095,980
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5957
    drug pathway 412
      blood and blood forming organs drug pathway 67
        antithrombotic drug pathway 67
          anticoagulant drug pathway 32
            vitamin K antagonist drug pathway 31
              warfarin drug pathway 31
                warfarin pharmacodynamics pathway 20
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.