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The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (

Term:warfarin pharmacodynamics pathway
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Accession:PW:0000731 term browser browse the term
Definition:The pathway of warfarin-target interaction and of the biochemical or physiological responses to drug. Warfarin is used as anticoagulant that antagonizes the vitamin K dependent clotting pathway. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00268

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warfarin pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COL1A1 collagen type I alpha 1 chain ISO SMPDB SMP:00268 NCBI chr12:26,379,087...26,397,180
Ensembl chr12:26,379,090...26,397,003
JBrowse link
G F10 coagulation factor X ISO SMPDB SMP:00268 NCBI chr11:78,521,760...78,538,256
Ensembl chr11:78,521,606...78,538,260
JBrowse link
G F11 coagulation factor XI ISO SMPDB SMP:00268 NCBI chr17:9,045,990...9,073,552
Ensembl chr17:9,045,997...9,073,520
JBrowse link
G F12 coagulation factor XII ISO SMPDB SMP:00268 NCBI chr 2:80,527,451...80,544,835
Ensembl chr 2:80,526,767...80,546,096
JBrowse link
G F13A1 coagulation factor XIII A chain ISO SMPDB SMP:00268 NCBI chr 7:3,751,290...3,900,797
Ensembl chr 7:3,751,291...3,900,765
JBrowse link
G F13B coagulation factor XIII B chain ISO SMPDB SMP:00268
G F2 coagulation factor II, thrombin ISO SMPDB SMP:00268 NCBI chr 2:15,793,257...15,819,151
Ensembl chr 2:15,791,451...15,819,138
JBrowse link
G F3 coagulation factor III, tissue factor ISO SMPDB SMP:00268 NCBI chr 4:122,827,018...122,837,673
Ensembl chr 4:122,826,992...122,837,672
JBrowse link
G F5 coagulation factor V ISO SMPDB SMP:00268 NCBI chr 4:81,403,273...81,484,908
Ensembl chr 4:81,403,232...81,485,055
JBrowse link
G F7 coagulation factor VII ISO SMPDB SMP:00268 NCBI chr11:78,512,389...78,518,668
Ensembl chr11:78,512,158...78,518,671
JBrowse link
G F8 coagulation factor VIII ISO SMPDB SMP:00268 NCBI chr  X:125,265,330...125,350,853
Ensembl chr  X:125,265,337...125,350,853
JBrowse link
G F9 coagulation factor IX ISO SMPDB SMP:00268 NCBI chr  X:114,218,704...114,250,436
Ensembl chr  X:114,218,707...114,250,436
JBrowse link
G FGA fibrinogen alpha chain ISO SMPDB SMP:00268 NCBI chr 8:74,574,870...74,584,202
Ensembl chr 8:74,574,882...74,584,202
JBrowse link
G FGB fibrinogen beta chain ISO SMPDB SMP:00268 NCBI chr 8:74,598,170...74,607,409
Ensembl chr 8:74,594,255...74,607,360
JBrowse link
G FGG fibrinogen gamma chain ISO SMPDB SMP:00268 NCBI chr 8:74,553,040...74,562,151
Ensembl chr 8:74,553,105...74,686,118
JBrowse link
G GGCX gamma-glutamyl carboxylase ISO SMPDB SMP:00268 NCBI chr 3:59,202,363...59,219,807
Ensembl chr 3:59,202,377...59,221,132
JBrowse link
G KLKB1 kallikrein B1 ISO SMPDB SMP:00268 NCBI chr15:47,071,581...47,100,272
Ensembl chr15:47,071,556...47,103,624
JBrowse link
G PLAT plasminogen activator, tissue type ISO SMPDB SMP:00268 NCBI chr17:11,195,599...11,223,821
Ensembl chr17:11,195,602...11,224,032
JBrowse link
G PLG plasminogen ISO SMPDB SMP:00268 NCBI chr 1:7,062,399...7,109,521
Ensembl chr 1:7,061,191...7,110,555
JBrowse link
G VKORC1 vitamin K epoxide reductase complex subunit 1 ISO SMPDB
PMID:26287237 RGD:11354881, SMP:00268 NCBI chr 3:17,386,230...17,389,162
Ensembl chr 3:17,386,441...17,396,840
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4027
    drug pathway 384
      blood and blood forming organs drug pathway 56
        antithrombotic drug pathway 56
          anticoagulant drug pathway 25
            vitamin K antagonist drug pathway 24
              warfarin drug pathway 24
                warfarin pharmacodynamics pathway 20
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.