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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:warfarin pharmacodynamics pathway
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Accession:PW:0000731 term browser browse the term
Definition:The pathway of warfarin-target interaction and of the biochemical or physiological responses to drug. Warfarin is used as anticoagulant that antagonizes the vitamin K dependent clotting pathway. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00268

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warfarin pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a1 collagen type I alpha 1 chain ISO SMPDB SMP:00268 NCBI chrNW_004936490:11,448,552...11,465,836 JBrowse link
G F11 coagulation factor XI ISO SMPDB SMP:00268 NCBI chrNW_004936554:3,205,539...3,223,228 JBrowse link
G F12 coagulation factor XII ISO SMPDB SMP:00268 NCBI chrNW_004936597:1,687,511...1,694,782 JBrowse link
G F13a1 coagulation factor XIII A chain ISO SMPDB SMP:00268 NCBI chrNW_004936534:6,199,066...6,360,374 JBrowse link
G F13b coagulation factor XIII B chain ISO SMPDB SMP:00268 NCBI chrNW_004936567:6,712,666...6,735,539 JBrowse link
G F2 coagulation factor II, thrombin ISO SMPDB SMP:00268 NCBI chrNW_004936562:2,371,725...2,388,617 JBrowse link
G F3 coagulation factor III, tissue factor ISO SMPDB SMP:00268 NCBI chrNW_004936537:4,637,028...4,647,915 JBrowse link
G F5 coagulation factor V ISO SMPDB SMP:00268 NCBI chrNW_004936481:17,114,441...17,178,902 JBrowse link
G F7 coagulation factor VII ISO SMPDB SMP:00268 NCBI chrNW_004936472:505,751...515,375 JBrowse link
G F8 coagulation factor VIII ISO SMPDB SMP:00268 NCBI chrNW_004936927:189,359...301,791 JBrowse link
G F9 coagulation factor IX ISO SMPDB SMP:00268 NCBI chrNW_004936513:8,052,998...8,090,245 JBrowse link
G Fga fibrinogen alpha chain ISO SMPDB SMP:00268 NCBI chrNW_004936576:1,322,406...1,329,743 JBrowse link
G Fgb fibrinogen beta chain ISO SMPDB SMP:00268 NCBI chrNW_004936576:1,306,076...1,313,485 JBrowse link
G Fgg fibrinogen gamma chain ISO SMPDB SMP:00268 NCBI chrNW_004936576:1,343,657...1,352,085 JBrowse link
G Ggcx gamma-glutamyl carboxylase ISO SMPDB SMP:00268 NCBI chrNW_004936712:1,696,264...1,709,087 JBrowse link
G Klkb1 kallikrein B1 ISO SMPDB SMP:00268 NCBI chrNW_004936554:3,227,395...3,256,710 JBrowse link
G LOC101961866 coagulation factor X ISO SMPDB SMP:00268 NCBI chrNW_004936472:475,851...502,341 JBrowse link
G Plat plasminogen activator, tissue type ISO SMPDB SMP:00268 NCBI chrNW_004936785:476,200...503,371 JBrowse link
G Plg plasminogen ISO SMPDB SMP:00268 NCBI chrNW_004936489:11,775,243...11,808,482 JBrowse link
G Vkorc1 vitamin K epoxide reductase complex subunit 1 ISO SMPDB
RGD
PMID:26287237 RGD:11354881, SMP:00268 NCBI chrNW_004936501:13,459,400...13,461,864 JBrowse link

Term paths to the root
Path 1
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  pathway 3930
    drug pathway 357
      blood and blood forming organs drug pathway 48
        antithrombotic drug pathway 48
          anticoagulant drug pathway 23
            vitamin K antagonist drug pathway 22
              warfarin drug pathway 22
                warfarin pharmacodynamics pathway 20
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.