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Term:chemokine mediated signaling pathway
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Accession:PW:0000829 term browser browse the term
Definition:Chemokine initiated pathways play important roles in the innate and adaptive immunity. They are also involved in development and tissue maintenance. The presence and localization of four cysteines is important for structural folding and is also the basis for chemokine classification. The spacing between the first two cysteine residues divides the family members into four groups. Most mammalian chemokines belong to the CC and CXC families. Chemokines signal via G-protein coupled receptors to engage distinct G protein signaling and downstream cascades.
Synonyms:related_synonym: KEGG:04062


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chemokine mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adcy1 adenylate cyclase 1 JBrowse link 14 87,311,970 87,429,880 RGD:6907045
G Adcy2 adenylate cyclase 2 JBrowse link 1 37,043,071 37,698,390 RGD:6907045
G Adcy3 adenylate cyclase 3 JBrowse link 6 28,570,941 28,648,848 RGD:6907045
G Adcy4 adenylate cyclase 4 JBrowse link 15 34,453,917 34,469,779 RGD:6907045
G Adcy5 adenylate cyclase 5 JBrowse link 11 68,695,839 68,842,452 RGD:6907045
G Adcy6 adenylate cyclase 6 JBrowse link 7 140,270,678 140,291,722 RGD:6907045
G Adcy7 adenylate cyclase 7 JBrowse link 19 19,702,307 19,762,973 RGD:6907045
G Adcy8 adenylate cyclase 8 JBrowse link 7 105,353,883 105,593,372 RGD:6907045
G Adcy9 adenylate cyclase 9 JBrowse link 10 11,392,698 11,515,406 RGD:6907045
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:6907045
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:6907045
G Bcar1 BCAR1 scaffold protein, Cas family member JBrowse link 19 43,932,543 43,967,452 RGD:6907045
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6907045
G Ccl1 C-C motif chemokine ligand 1 JBrowse link 10 69,534,976 69,537,836 RGD:6907045
G Ccl11 C-C motif chemokine ligand 11 JBrowse link 10 69,434,965 69,439,566 RGD:6907045
G Ccl12 chemokine (C-C motif) ligand 12 JBrowse link 10 69,476,866 69,478,416 RGD:6907045
G Ccl17 C-C motif chemokine ligand 17 JBrowse link 19 10,619,220 10,620,671 RGD:6907045
G Ccl19 C-C motif chemokine ligand 19 JBrowse link 5 58,181,025 58,182,969 RGD:6907045
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6907045
G Ccl20 C-C motif chemokine ligand 20 JBrowse link 9 88,918,359 88,921,017 RGD:6907045
G Ccl22 C-C motif chemokine ligand 22 JBrowse link 19 10,674,189 10,681,145 RGD:6907045
G Ccl24 C-C motif chemokine ligand 24 JBrowse link 12 24,131,529 24,152,626 RGD:6907045
G Ccl25 C-C motif chemokine ligand 25 JBrowse link 12 2,429,492 2,438,928 RGD:6907045
G Ccl26 C-C motif chemokine ligand 26 JBrowse link 12 24,157,182 24,161,870 RGD:6907045
G Ccl27 C-C motif chemokine ligand 27 JBrowse link 5 58,159,066 58,166,182 RGD:6907045
G Ccl28 C-C motif chemokine ligand 28 JBrowse link 2 52,379,341 52,403,979 RGD:6907045
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:6907045
G Ccl4 C-C motif chemokine ligand 4 JBrowse link 10 70,870,926 70,886,357 RGD:6907045
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:6907045
G Ccl6 chemokine (C-C motif) ligand 6 JBrowse link 10 70,798,118 70,802,750 RGD:6907045
G Ccl7 C-C motif chemokine ligand 7 JBrowse link 10 69,423,083 69,424,933 RGD:6907045
G Ccl9 chemokine (C-C motif) ligand 9 JBrowse link 10 70,783,426 70,788,372 RGD:6907045
G Ccr1 C-C motif chemokine receptor 1 JBrowse link 8 132,996,646 133,002,201 RGD:6907045
G Ccr10 C-C motif chemokine receptor 10 JBrowse link 10 89,086,556 89,088,993 RGD:6907045
G Ccr1l1 chemokine (C-C motif) receptor 1-like 1 JBrowse link 8 133,127,220 133,128,290 RGD:6907045
G Ccr2 C-C motif chemokine receptor 2 RGD:6907045
G Ccr3 C-C motif chemokine receptor 3 JBrowse link 8 133,026,539 133,040,999 RGD:6907045
G Ccr4 C-C motif chemokine receptor 4 JBrowse link 8 122,530,152 122,535,959 RGD:6907045
G Ccr5 C-C motif chemokine receptor 5 JBrowse link 8 133,192,398 133,215,599 RGD:6907045
G Ccr6 C-C motif chemokine receptor 6 JBrowse link 1 53,063,380 53,087,519 RGD:6907045
G Ccr7 C-C motif chemokine receptor 7 JBrowse link 10 87,057,335 87,067,444 RGD:6907045
G Ccr8 C-C motif chemokine receptor 8 JBrowse link 8 128,779,552 128,782,531 RGD:6907045
G Ccr9 C-C motif chemokine receptor 9 JBrowse link 8 132,827,325 132,842,130 RGD:6907045
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:6907045
G Chuk component of inhibitor of nuclear factor kappa B kinase complex JBrowse link 1 263,848,829 263,884,354 RGD:6907045
G Crk CRK proto-oncogene, adaptor protein JBrowse link 10 63,829,731 63,855,999 RGD:6907045
G Crkl CRK like proto-oncogene, adaptor protein JBrowse link 11 87,338,606 87,356,644 RGD:6907045
G Csk C-terminal Src kinase JBrowse link 8 62,405,714 62,424,707 RGD:6907045
G Cx3cl1 C-X3-C motif chemokine ligand 1 JBrowse link 19 10,644,267 10,654,861 RGD:6907045
G Cx3cr1 C-X3-C motif chemokine receptor 1 JBrowse link 8 128,740,756 128,754,514 RGD:6907045
G Cxcl1 C-X-C motif chemokine ligand 1 JBrowse link 14 18,743,678 18,745,457 RGD:6907045
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:6907045
G Cxcl11 C-X-C motif chemokine ligand 11 JBrowse link 14 17,195,395 17,198,170 RGD:6907045
G Cxcl12 C-X-C motif chemokine ligand 12 JBrowse link 4 149,261,044 149,273,891 RGD:6907045
G Cxcl13 C-X-C motif chemokine ligand 13 JBrowse link 14 15,253,146 15,258,221 RGD:6907045
G Cxcl14 C-X-C motif chemokine ligand 14 JBrowse link 17 9,109,731 9,117,754 RGD:6907045
G Cxcl16 C-X-C motif chemokine ligand 16 JBrowse link 10 57,060,005 57,064,600 RGD:6907045
G Cxcl2 C-X-C motif chemokine ligand 2 JBrowse link 14 18,731,346 18,733,391 RGD:6907045
G Cxcl9 C-X-C motif chemokine ligand 9 JBrowse link 14 17,228,832 17,233,743 RGD:6907045
G Cxcr3 C-X-C motif chemokine receptor 3 JBrowse link X 71,614,346 71,616,997 RGD:6907045
G Cxcr4 C-X-C motif chemokine receptor 4 JBrowse link 13 45,314,952 45,318,856 RGD:6907045
G Cxcr5 C-X-C motif chemokine receptor 5 JBrowse link 8 48,835,688 48,852,032 RGD:6907045
G Cxcr6 C-X-C motif chemokine receptor 6 JBrowse link 8 132,869,712 132,870,766 RGD:6907045
G Dock2 dedicator of cytokinesis 2 JBrowse link 10 19,181,512 19,603,171 RGD:6907045
G Elmo1 engulfment and cell motility 1 JBrowse link 17 46,352,102 46,888,788 RGD:6907045
G Fgr FGR proto-oncogene, Src family tyrosine kinase JBrowse link 5 151,172,189 151,199,746 RGD:6907045
G Foxo3 forkhead box O3 JBrowse link 20 46,428,078 46,519,156 RGD:6907045
G Gnai1 G protein subunit alpha i1 JBrowse link 4 13,405,136 13,486,866 RGD:6907045
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:6907045
G Gnai3 G protein subunit alpha i3 JBrowse link 2 210,896,779 210,934,733 RGD:6907045
G Gnb1 G protein subunit beta 1 JBrowse link 5 172,914,025 172,981,403 RGD:6907045
G Gnb2 G protein subunit beta 2 JBrowse link 12 22,229,079 22,234,096 RGD:6907045
G Gnb3 G protein subunit beta 3 JBrowse link 4 157,352,558 157,359,237 RGD:6907045
G Gnb4 G protein subunit beta 4 JBrowse link 2 118,978,965 119,007,877 RGD:6907045
G Gnb5 G protein subunit beta 5 JBrowse link 8 82,248,951 82,286,493 RGD:6907045
G Gng10 G protein subunit gamma 10 JBrowse link 5 76,182,100 76,189,014 RGD:6907045
G Gng11 G protein subunit gamma 11 JBrowse link 4 28,989,170 28,994,610 RGD:6907045
G Gng12 G protein subunit gamma 12 JBrowse link 4 97,634,925 97,763,478 RGD:6907045
G Gng13 G protein subunit gamma 13 JBrowse link 10 15,088,935 15,090,839 RGD:6907045
G Gng2 G protein subunit gamma 2 JBrowse link 15 4,748,242 4,853,555 RGD:6907045
G Gng3 G protein subunit gamma 3 JBrowse link 1 225,033,921 225,035,687 RGD:6907045
G Gng4 G protein subunit gamma 4 JBrowse link 17 90,266,571 90,316,278 RGD:6907045
G Gng5 G protein subunit gamma 5 JBrowse link 2 252,359,976 252,368,473 RGD:6907045
G Gng7 G protein subunit gamma 7 JBrowse link 7 11,565,740 11,629,519 RGD:6907045
G Gng8 G protein subunit gamma 8 JBrowse link 1 78,818,360 78,822,224 RGD:6907045
G Gngt1 G protein subunit gamma transducin 1 JBrowse link 4 28,972,339 28,975,419 RGD:6907045
G Gngt2 G protein subunit gamma transducin 2 JBrowse link 10 83,654,321 83,658,601 RGD:6907045
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:6907045
G Grk1 G protein-coupled receptor kinase 1 JBrowse link 16 81,153,489 81,165,442 RGD:6907045
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:6907045
G Grk3 G protein-coupled receptor kinase 3 JBrowse link 12 49,626,871 49,750,389 RGD:6907045
G Grk4 G protein-coupled receptor kinase 4 JBrowse link 14 81,261,708 81,339,516 RGD:6907045
G Grk5 G protein-coupled receptor kinase 5 JBrowse link 1 282,265,371 282,467,842 RGD:6907045
G Grk6 G protein-coupled receptor kinase 6 JBrowse link 17 9,705,917 9,721,921 RGD:6907045
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link 1 82,097,244 82,108,238 RGD:6907045
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6907045
G Hck HCK proto-oncogene, Src family tyrosine kinase JBrowse link 3 148,579,917 148,623,026 RGD:6907045
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6907045
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6907045
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:6907045
G Itk IL2-inducible T-cell kinase JBrowse link 10 31,431,820 31,493,413 RGD:6907045
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:6907045
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:6907045
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6907045
G Lyn LYN proto-oncogene, Src family tyrosine kinase JBrowse link 5 16,526,058 16,642,648 RGD:6907045
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Ncf1 neutrophil cytosolic factor 1 JBrowse link 12 25,497,104 25,506,300 RGD:6907045
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6907045
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6907045
G Nfkbib NFKB inhibitor beta JBrowse link 1 86,941,073 86,948,845 RGD:6907045
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:6907045
G Pak1 p21 (RAC1) activated kinase 1 JBrowse link 1 162,768,156 162,883,356 RGD:6907045
G Pard3 par-3 family cell polarity regulator JBrowse link 19 60,017,746 60,580,628 RGD:6907045
G Pf4 platelet factor 4 JBrowse link 14 18,848,549 18,849,258 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Plcb1 phospholipase C beta 1 JBrowse link 3 127,721,244 128,419,565 RGD:6907045
G Plcb2 phospholipase C, beta 2 JBrowse link 3 110,497,760 110,517,563 RGD:6907045
G Plcb3 phospholipase C beta 3 JBrowse link 1 222,207,887 222,224,993 RGD:6907045
G Plcb4 phospholipase C, beta 4 JBrowse link 3 128,601,163 128,971,720 RGD:6907045
G Ppbp pro-platelet basic protein JBrowse link 14 18,852,433 18,853,237 RGD:6907045
G Prex1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 JBrowse link 3 163,329,580 163,477,822 RGD:6907045
G Prkaca protein kinase cAMP-activated catalytic subunit alpha JBrowse link 19 25,095,089 25,118,869 RGD:6907045
G Prkacb protein kinase cAMP-activated catalytic subunit beta JBrowse link 2 252,602,197 252,691,886 RGD:6907045
G Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:6907045
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:6907045
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:6907045
G Prkx protein kinase, X-linked JBrowse link X 45,080,963 45,125,095 RGD:6907045
G Ptk2 protein tyrosine kinase 2 JBrowse link 7 114,436,419 114,611,317 RGD:6907045
G Ptk2b protein tyrosine kinase 2 beta JBrowse link 15 42,827,306 42,947,796 RGD:6907045
G Pxn paxillin JBrowse link 12 46,797,953 46,845,107 RGD:6907045
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:6907045
G Rac2 Rac family small GTPase 2 JBrowse link 7 119,769,708 119,797,111 RGD:6907045
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045
G Rap1a RAP1A, member of RAS oncogene family JBrowse link 2 208,193,950 208,215,186 RGD:6907045
G Rap1b RAP1B, member of RAS oncogene family JBrowse link 7 60,850,406 60,878,226 RGD:6907045
G Rasgrp2 RAS guanyl releasing protein 2 JBrowse link 1 221,771,238 221,788,765 RGD:6907045
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6907045
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:6907045
G Rock1 Rho-associated coiled-coil containing protein kinase 1 JBrowse link 18 1,273,490 1,390,790 RGD:6907045
G Rock2 Rho-associated coiled-coil containing protein kinase 2 JBrowse link 6 42,180,864 42,289,910 RGD:6907045
G RSA-14-44 RSA-14-44 protein JBrowse link 4 96,831,880 96,833,252 RGD:6907045
G Shc1 SHC adaptor protein 1 JBrowse link 2 188,745,503 188,757,066 RGD:6907045
G Shc2 SHC adaptor protein 2 JBrowse link 7 12,948,952 12,971,174 RGD:6907045
G Shc3 SHC adaptor protein 3 JBrowse link 17 13,670,520 13,791,043 RGD:6907045
G Shc4 SHC adaptor protein 4 JBrowse link 3 117,897,738 117,990,289 RGD:6907045
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:6907045
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:6907045
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6907045
G Stat2 signal transducer and activator of transcription 2 JBrowse link 7 2,691,064 2,707,530 RGD:6907045
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6907045
G Stat5b signal transducer and activator of transcription 5B JBrowse link 10 88,686,207 88,712,313 RGD:6907045
G Tiam1 TIAM Rac1 associated GEF 1 JBrowse link 11 29,931,083 30,061,173 RGD:6907045
G Vav1 vav guanine nucleotide exchange factor 1 JBrowse link 9 9,617,551 9,675,167 RGD:6907045
G Vav2 vav guanine nucleotide exchange factor 2 JBrowse link 3 5,811,504 5,976,311 RGD:6907045
G Vav3 vav guanine nucleotide exchange factor 3 JBrowse link 2 212,247,061 212,585,818 RGD:6907045
G Was WASP actin nucleation promoting factor JBrowse link X 15,155,246 15,164,099 RGD:6907045
G Wasl WASP like actin nucleation promoting factor JBrowse link 4 51,677,722 51,726,212 RGD:6907045
G Xcl1 X-C motif chemokine ligand 1 JBrowse link 13 83,199,402 83,202,845 RGD:6907045
G Xcr1 X-C motif chemokine receptor 1 JBrowse link 8 132,911,474 132,919,110 RGD:6907045

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  pathway 6015
    signaling pathway 2572
      signaling pathway pertinent to immunity 779
        chemokine mediated signaling pathway 170
          C chemokine mediated signaling pathway 0
          CC chemokine mediated signaling pathway + 0
          CX3C chemokine mediated signaling pathway 0
          CXC chemokine mediated signaling pathway + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.