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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:acetylcholine signaling pathway via nicotinic acetylcholine receptor
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Accession:PW:0000842 term browser browse the term
Definition:Activation of the pentameric ionotropic nicotinic acetylcholine receptor leads to membrane depolarization and subsequent excitatory transmission. A salient feature of presynaptic signaling is promoting the release of various neurotransmitters depending on the neuron expressing the receptors.

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acetylcholine signaling pathway via nicotinic acetylcholine receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase ISO RGD PMID:17786266 RGD:8549506 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Agrn agrin ISO RGD PMID:23032192 RGD:8549508 NCBI chr 5:173,589,910...173,622,813
Ensembl chr 5:173,589,819...173,622,645
JBrowse link
G Chat choline O-acetyltransferase ISO RGD PMID:23677775 RGD:8549504 NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131
JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit ISO RGD PMID:23032192, PMID:19126755 RGD:8549508, RGD:8549510 NCBI chr 3:60,445,657...60,460,724
Ensembl chr 3:60,445,666...60,460,724
JBrowse link
G Chrna10 cholinergic receptor nicotinic alpha 10 subunit ISO RGD PMID:19126755 RGD:8549510 NCBI chr 1:167,206,722...167,212,199
Ensembl chr 1:167,206,722...167,210,919
JBrowse link
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit ISO RGD PMID:19126755 RGD:8549510 NCBI chr15:42,808,897...42,825,179
Ensembl chr15:42,808,897...42,825,179
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit ISO RGD PMID:19126755 RGD:8549510 NCBI chr 8:59,594,007...59,607,122
Ensembl chr 8:59,592,403...59,607,275
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit ISO RGD PMID:19126755 RGD:8549510 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit ISO RGD PMID:19126755 RGD:8549510 NCBI chr 8:59,561,817...59,590,172
Ensembl chr 8:59,561,721...59,590,172
JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit ISO RGD PMID:19126755 RGD:8549510 NCBI chr16:68,860,018...68,866,718
Ensembl chr16:68,860,018...68,866,718
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit ISO RGD PMID:19126755 RGD:8549510 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Chrna9 cholinergic receptor nicotinic alpha 9 subunit ISO RGD PMID:19126755 RGD:8549510 NCBI chr14:43,883,450...43,890,171
Ensembl chr14:43,883,458...43,890,171
JBrowse link
G Chrnb1 cholinergic receptor nicotinic beta 1 subunit ISO RGD PMID:23032192, PMID:19126755 RGD:8549508, RGD:8549510 NCBI chr10:56,390,671...56,403,255
Ensembl chr10:56,390,671...56,403,188
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit ISO RGD PMID:19126755 RGD:8549510 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit ISO RGD PMID:19126755 RGD:8549510 NCBI chr16:68,876,442...68,913,628
Ensembl chr16:68,875,709...68,913,628
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit ISO RGD PMID:19126755 RGD:8549510 NCBI chr 8:59,610,489...59,629,073
Ensembl chr 8:59,609,693...59,629,133
JBrowse link
G Chrnd cholinergic receptor nicotinic delta subunit ISO RGD PMID:23032192, PMID:19126755 RGD:8549508, RGD:8549510 NCBI chr 9:94,286,550...94,294,968
Ensembl chr 9:94,286,550...94,294,968
JBrowse link
G Chrne cholinergic receptor nicotinic epsilon subunit ISO RGD PMID:23032192, PMID:19126755 RGD:8549508, RGD:8549510 NCBI chr10:57,238,960...57,246,750
Ensembl chr10:57,238,946...57,243,435
JBrowse link
G Chrng cholinergic receptor nicotinic gamma subunit ISO RGD PMID:23032192, PMID:19126755 RGD:8549508, RGD:8549510 NCBI chr 9:94,302,218...94,308,591 JBrowse link
G Dok7 docking protein 7 ISO RGD PMID:23032192 RGD:8549508 NCBI chr14:80,925,409...80,963,454
Ensembl chr14:80,926,654...80,958,478
JBrowse link
G Lrp4 LDL receptor related protein 4 ISO RGD PMID:23032192 RGD:8549508 NCBI chr 3:80,362,643...80,416,684
Ensembl chr 3:80,362,858...80,416,679
JBrowse link
G Musk muscle associated receptor tyrosine kinase ISO RGD PMID:23032192 RGD:8549508 NCBI chr 5:75,392,790...75,498,694
Ensembl chr 5:75,392,790...75,498,694
JBrowse link
G Rapsn receptor-associated protein of the synapse ISO RGD PMID:23032192 RGD:8549508 NCBI chr 3:79,859,815...79,869,486
Ensembl chr 3:79,860,179...79,869,524
JBrowse link
G Slc18a3 solute carrier family 18 member A3 ISO RGD PMID:23677775 RGD:8549504 NCBI chr16:8,682,668...8,685,529
Ensembl chr16:8,682,669...8,685,529
JBrowse link
G Slc5a7 solute carrier family 5 member 7 ISO RGD PMID:23677775 RGD:8549504 NCBI chr 9:5,294,377...5,330,822
Ensembl chr 9:5,294,381...5,330,815
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6103
    signaling pathway 2646
      chemical compound signaling pathway 85
        acetylcholine signaling pathway 40
          acetylcholine signaling pathway via nicotinic acetylcholine receptor 25
Path 2
Term Annotations click to browse term
  pathway 6103
    signaling pathway 2646
      signaling pathway pertinent to the brain and nervous system 463
        neuron-to-neuron signaling pathways 281
          neuron-to-neuron signaling pathway via the chemical synapse 279
            acetylcholine signaling pathway 40
              acetylcholine signaling pathway via nicotinic acetylcholine receptor 25
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.