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Term:interleukin-4 signaling pathway
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Accession:PW:0000912 term browser browse the term
Definition:Interleukin-4 is a member of interleukin 2 family of cytokine whose signaling is important for the differentiation of naive T helper cells.
Synonyms:exact_synonym: Il-4 signaling pathway
 related_synonym: PID:200022


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interleukin-4 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aicda activation-induced cytidine deaminase JBrowse link 4 155,359,909 155,371,104 RGD:6484113
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6484113
G Alox15 arachidonate 15-lipoxygenase JBrowse link 10 56,953,692 56,962,145 RGD:6484113
G Arg1 arginase 1 JBrowse link 1 21,525,421 21,537,872 RGD:6484113
G Bcl6 BCL6, transcription repressor JBrowse link 11 80,255,790 80,279,075 RGD:6484113
G Cbl Cbl proto-oncogene JBrowse link 8 48,481,256 48,564,775 RGD:6484113
G Ccl11 C-C motif chemokine ligand 11 JBrowse link 10 69,434,965 69,439,566 RGD:6484113
G Ccl17 C-C motif chemokine ligand 17 JBrowse link 19 10,619,220 10,620,671 RGD:6484113
G Ccl26 C-C motif chemokine ligand 26 JBrowse link 12 24,157,182 24,161,870 RGD:6484113
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:6484113
G Cebpb CCAAT/enhancer binding protein beta JBrowse link 3 164,424,502 164,425,933 RGD:6484113
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:6484113
G Col1a2 collagen type I alpha 2 chain JBrowse link 4 31,534,225 31,569,152 RGD:6484113
G Dok2 docking protein 2 JBrowse link 15 52,449,884 52,455,414 RGD:6484113
G Egr2 early growth response 2 JBrowse link 20 22,452,170 22,461,018 RGD:6484113
G Ets1 ETS proto-oncogene 1, transcription factor JBrowse link 8 33,756,634 33,879,625 RGD:6484113
G Fcer2 Fc fragment of IgE receptor II JBrowse link 12 2,233,772 2,245,324 RGD:6484113
G Fes FES proto-oncogene, tyrosine kinase JBrowse link 1 142,174,648 142,183,884 RGD:6484113
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:6484113
G Gtf3a general transcription factor III A JBrowse link 12 9,856,841 9,864,791 RGD:6484113
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6484113
G Il13ra2 interleukin 13 receptor subunit alpha 2 JBrowse link X 118,443,955 118,514,716 RGD:6484113
G Il2rg interleukin 2 receptor subunit gamma JBrowse link X 71,165,378 71,169,078 RGD:6484113
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6484113
G Il4r interleukin 4 receptor JBrowse link 1 196,942,343 196,967,221 RGD:6484113
G Il5 interleukin 5 JBrowse link 10 39,066,716 39,069,587 RGD:6484113
G Inpp5d inositol polyphosphate-5-phosphatase D JBrowse link 9 94,745,220 94,850,778 RGD:6484113
G Irf4 interferon regulatory factor 4 JBrowse link 17 34,886,746 34,905,191 RGD:6484113
G Irs1 insulin receptor substrate 1 JBrowse link 9 88,033,668 88,086,488 RGD:6484113
G Irs2 insulin receptor substrate 2 JBrowse link 16 83,824,515 83,848,569 RGD:6484113
G Itgb3 integrin subunit beta 3 JBrowse link 10 92,667,869 92,783,413 RGD:6484113
G Jak1 Janus kinase 1 JBrowse link 5 119,982,503 120,091,452 RGD:6484113
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:6484113
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:6484113
G LOC100360218 interleukin 13 receptor, alpha 1-like JBrowse link 11 74,864,036 74,866,477 RGD:6484113
G Lta lymphotoxin alpha JBrowse link 20 4,851,889 4,854,677 RGD:6484113
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6484113
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:6484113
G Mybl1 MYB proto-oncogene like 1 JBrowse link 5 9,279,756 9,315,112 RGD:6484113
G Oprm1 opioid receptor, mu 1 JBrowse link 1 43,454,803 43,704,948 RGD:6484113
G Parp14 poly (ADP-ribose) polymerase family, member 14 JBrowse link 11 68,105,442 68,137,509 RGD:6484113
G Pigr polymeric immunoglobulin receptor JBrowse link 13 47,564,176 47,592,093 RGD:6484113
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6484113
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:6484113
G Retnlb resistin like beta JBrowse link 11 54,565,471 54,567,578 RGD:6484113
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6484113
G Selp selectin P JBrowse link 13 82,428,914 82,464,629 RGD:6484113
G Shc1 SHC adaptor protein 1 JBrowse link 2 188,745,503 188,757,066 RGD:6484113
G Socs1 suppressor of cytokine signaling 1 JBrowse link 10 4,956,795 4,958,472 RGD:6484113
G Socs3 suppressor of cytokine signaling 3 JBrowse link 10 106,973,863 106,976,969 RGD:6484113
G Socs5 suppressor of cytokine signaling 5 JBrowse link 6 10,671,311 10,705,610 RGD:6484113
G Sp1 Sp1 transcription factor JBrowse link 7 144,014,173 144,044,635 RGD:6484113
G Spi1 Spi-1 proto-oncogene JBrowse link 3 79,918,127 79,937,708 RGD:6484113
G Stat5a signal transducer and activator of transcription 5A JBrowse link 10 88,764,732 88,789,060 RGD:6484113
G Stat5b signal transducer and activator of transcription 5B JBrowse link 10 88,686,207 88,712,313 RGD:6484113
G Stat6 signal transducer and activator of transcription 6 JBrowse link 7 70,946,228 70,963,542 RGD:6484113
G Tff3 trefoil factor 3 JBrowse link 20 9,850,800 9,855,481 RGD:6484113
G Thy1 Thy-1 cell surface antigen JBrowse link 8 48,382,121 48,387,271 RGD:6484113

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6016
    signaling pathway 2585
      signaling pathway pertinent to immunity 779
        cytokine mediated signaling pathway 473
          Interleukin mediated signaling pathway 245
            interleukin-2 family mediated signaling pathway 98
              interleukin-4 signaling pathway 59
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.