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Term:interleukin-4 signaling pathway
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Accession:PW:0000912 term browser browse the term
Definition:Interleukin-4 is a member of interleukin 2 family of cytokine whose signaling is important for the differentiation of naive T helper cells.
Synonyms:exact_synonym: Il-4 signaling pathway
 related_synonym: PID:200022

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interleukin-4 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link NW_004955538 3,208,711 3,224,386 RGD:9068941
G Alox15 arachidonate 15-lipoxygenase JBrowse link NW_004955467 10,032,792 10,039,789 RGD:9068941
G Arg1 arginase 1 JBrowse link NW_004955436 12,235,767 12,247,817 RGD:9068941
G Bcl6 BCL6 transcription repressor JBrowse link NW_004955420 19,998,960 20,021,200 RGD:9068941
G Cbl Cbl proto-oncogene JBrowse link NW_004955412 20,307,011 20,388,539 RGD:9068941
G Ccl17 C-C motif chemokine ligand 17 JBrowse link NW_004955433 15,052,616 15,054,732 RGD:9068941
G Ccl26 C-C motif chemokine ligand 26 JBrowse link NW_004955456 14,554,583 14,558,967 RGD:9068941
G Cd40lg CD40 ligand JBrowse link NW_004955489 8,465,571 8,477,714 RGD:9068941
G Cebpb CCAAT enhancer binding protein beta JBrowse link NW_004955445 8,060,432 8,061,289 RGD:9068941
G Col1a1 collagen type I alpha 1 chain JBrowse link NW_004955451 11,468,156 11,484,410 RGD:9068941
G Col1a2 collagen type I alpha 2 chain JBrowse link NW_004955432 11,127,961 11,164,145 RGD:9068941
G Dok2 docking protein 2 JBrowse link NW_004955403 45,410,689 45,421,366 RGD:9068941
G Egr2 early growth response 2 JBrowse link NW_004955425 16,055,748 16,068,429 RGD:9068941
G Ets1 ETS proto-oncogene 1, transcription factor JBrowse link NW_004955412 29,433,730 29,602,389 RGD:9068941
G Fcer2 Fc fragment of IgE receptor II JBrowse link NW_004955563 1,587,471 1,596,707 RGD:9068941
G Fes FES proto-oncogene, tyrosine kinase JBrowse link NW_004955416 14,948,121 14,959,035 RGD:9068941
G Grb2 growth factor receptor bound protein 2 JBrowse link NW_004955553 2,186,590 2,258,964 RGD:9068941
G Gtf3a general transcription factor IIIA JBrowse link NW_004955497 6,836,568 6,852,177 RGD:9068941
G Hmga1 high mobility group AT-hook 1 JBrowse link NW_004955437 2,478,414 2,486,809 RGD:9068941
G Il10 interleukin 10 JBrowse link NW_004955406 42,307,789 42,312,255 RGD:9068941
G Il13ra1 interleukin 13 receptor subunit alpha 1 JBrowse link NW_004955534 1,157,758 1,205,158 RGD:9068941
G Il13ra2 interleukin 13 receptor subunit alpha 2 JBrowse link NW_004955490 708,144 758,195 RGD:9068941
G Il2rg interleukin 2 receptor subunit gamma JBrowse link NW_004955475 10,676,592 10,680,565 RGD:9068941
G Il4 interleukin 4 JBrowse link NW_004955408 4,058,052 4,065,999 RGD:9068941
G Il4r interleukin 4 receptor JBrowse link NW_004955493 5,546,340 5,580,745 RGD:9068941
G Il5 interleukin 5 JBrowse link NW_004955408 3,937,128 3,951,784 RGD:9068941
G Inpp5d inositol polyphosphate-5-phosphatase D JBrowse link NW_004955453 2,938,659 3,037,211 RGD:9068941
G Irf4 interferon regulatory factor 4 JBrowse link NW_004955465 12,497,534 12,512,529 RGD:9068941
G Irs1 insulin receptor substrate 1 JBrowse link NW_004955453 7,685,715 7,742,262 RGD:9068941
G Irs2 insulin receptor substrate 2 JBrowse link NW_004955404 2,531,484 2,555,383 RGD:9068941
G Itgb3 integrin subunit beta 3 JBrowse link NW_004955478 9,788,192 9,830,254 RGD:9068941
G Jak1 Janus kinase 1 JBrowse link NW_004955423 25,501,989 25,581,826 RGD:9068941
G Jak2 Janus kinase 2 JBrowse link NW_004955434 9,227,897 9,341,208 RGD:9068941
G Jak3 Janus kinase 3 JBrowse link NW_004955524 3,399,895 3,412,018 RGD:9068941
G Lta lymphotoxin alpha JBrowse link NW_004955437 114,216 116,003 RGD:9068941
G Mapk14 mitogen-activated protein kinase 14 JBrowse link NW_004955437 3,836,331 3,884,083 RGD:9068941
G Mtor mechanistic target of rapamycin kinase JBrowse link NW_004955486 2,487,642 2,599,694 RGD:9068941
G Myb MYB proto-oncogene, transcription factor JBrowse link NW_004955439 1,523,516 1,560,185 RGD:9068941
G Mybl1 MYB proto-oncogene like 1 JBrowse link NW_004955444 12,589,464 12,620,602 RGD:9068941
G Oprm1 opioid receptor mu 1 JBrowse link NW_004955439 7,870,563 7,923,817 RGD:9068941
G Parp14 poly(ADP-ribose) polymerase family member 14 JBrowse link NW_004955427 21,878,980 21,929,097 RGD:9068941
G Pigr polymeric immunoglobulin receptor JBrowse link NW_004955406 42,456,450 42,474,489 RGD:9068941
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link NW_004955420 8,355,415 8,427,024 RGD:9068941
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link NW_004955446 1,020,707 1,098,327 RGD:9068941
G Ptpn6 protein tyrosine phosphatase non-receptor type 6 JBrowse link NW_004955413 4,525,954 4,547,177 RGD:9068941
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link NW_004955451 3,181,085 3,225,610 RGD:9068941
G Selp selectin P JBrowse link NW_004955462 7,658,371 7,692,870 RGD:9068941
G Shc1 SHC adaptor protein 1 JBrowse link NW_004955545 1,468,391 1,479,209 RGD:9068941
G Socs1 suppressor of cytokine signaling 1 JBrowse link NW_004955442 7,321,337 7,323,109 RGD:9068941
G Socs3 suppressor of cytokine signaling 3 JBrowse link NW_004955506 4,222,455 4,225,563 RGD:9068941
G Socs5 suppressor of cytokine signaling 5 JBrowse link NW_004955441 13,593,342 13,657,389 RGD:9068941
G Sp1 Sp1 transcription factor JBrowse link NW_004955458 644,435 677,360 RGD:9068941
G Spi1 Spi-1 proto-oncogene JBrowse link NW_004955422 873,735 886,560 RGD:9068941
G Stat5a signal transducer and activator of transcription 5A JBrowse link NW_004955451 16,305,363 16,319,219 RGD:9068941
G Stat5b signal transducer and activator of transcription 5B JBrowse link NW_004955451 16,253,645 16,295,337 RGD:9068941
G Stat6 signal transducer and activator of transcription 6 JBrowse link NW_004955458 4,833,417 4,847,956 RGD:9068941
G Tff3 trefoil factor 3 JBrowse link NW_004955407 39,398,534 39,401,085 RGD:9068941
G Thy1 Thy-1 cell surface antigen JBrowse link NW_004955412 20,480,284 20,484,958 RGD:9068941

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Term Annotations click to browse term
  pathway 5435
    signaling pathway 2370
      signaling pathway pertinent to immunity 541
        cytokine mediated signaling pathway 317
          Interleukin mediated signaling pathway 234
            interleukin-2 family mediated signaling pathway 97
              interleukin-4 signaling pathway 58
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.