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ONTOLOGY REPORT - ANNOTATIONS


Term:E-cadherin signaling pathway
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Accession:PW:0000992 term browser browse the term
Definition:E-cadherin or the epithelial cadherin encoded by the Cdh1 gene, is a member of the classical cadherin family and among the best studied cadherin pathway. Deregulation of the pathway has been associated with several forms of cancer.
Synonyms:related_synonym: Cdh1 signaling pathway;   PID:200124;   PID:200147;   PID:200182


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E-cadherin signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abi1 abl-interactor 1 JBrowse link 17 89,951,662 90,033,334 RGD:6484113
G Actn1 actinin, alpha 1 JBrowse link 6 103,376,557 103,470,497 RGD:6484113
G Ajuba ajuba LIM protein JBrowse link 15 33,208,210 33,218,456 RGD:6484113
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6484113
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6484113
G Ap1m1 adaptor related protein complex 1 subunit mu 1 JBrowse link 16 19,288,354 19,303,818 RGD:6484113
G Aqp3 aquaporin 3 (Gill blood group) JBrowse link 5 57,423,735 57,429,252 RGD:6484113
G Aqp5 aquaporin 5 JBrowse link 7 141,249,044 141,252,576 RGD:6484113
G Arf6 ADP-ribosylation factor 6 JBrowse link 6 91,697,109 91,698,257 RGD:6484113
G Camsap3 calmodulin regulated spectrin-associated protein family, member 3 JBrowse link 12 2,133,935 2,157,403 RGD:6484113
G Casr calcium-sensing receptor JBrowse link 11 67,188,204 67,262,261 RGD:6484113
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6484113
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:6484113
G Cdh1 cadherin 1 JBrowse link 19 38,768,467 38,838,395 RGD:6484113
G Crk CRK proto-oncogene, adaptor protein JBrowse link 10 63,829,731 63,855,999 RGD:6484113
G Csnk2a1 casein kinase 2 alpha 1 JBrowse link 3 147,713,808 147,760,375 RGD:6484113
G Csnk2a2 casein kinase 2 alpha 2 JBrowse link 19 9,972,537 10,012,043 RGD:6484113
G Csnk2b casein kinase 2 beta JBrowse link 20 5,108,692 5,113,675 RGD:6484113
G Ctnna1 catenin alpha 1 JBrowse link 18 27,923,229 28,055,972 RGD:6484113
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6484113
G Ctnnd1 catenin delta 1 JBrowse link 3 72,001,904 72,053,047 RGD:6484113
G Cttn cortactin JBrowse link 1
1
217,602,698
215,255,385
217,638,196
215,290,882
RGD:6484113
G Diaph1 diaphanous-related formin 1 JBrowse link 18 30,972,907 31,071,371 RGD:6484113
G Dlg1 discs large MAGUK scaffold protein 1 JBrowse link 11 72,164,566 72,378,895 RGD:6484113
G Efna1 ephrin A1 JBrowse link 2 188,588,808 188,596,156 RGD:6484113
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6484113
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6484113
G Enah ENAH, actin regulator JBrowse link 13 100,297,421 100,415,335 RGD:6484113
G Epha2 Eph receptor A2 JBrowse link 5 159,845,773 159,874,203 RGD:6484113
G Exoc3 exocyst complex component 3 JBrowse link 1 31,700,953 31,731,726 RGD:6484113
G Exoc4 exocyst complex component 4 JBrowse link 4 60,549,128 61,358,305 RGD:6484113
G Fmn1 formin 1 JBrowse link 3 104,783,093 105,170,761 RGD:6484113
G Fyn FYN proto-oncogene, Src family tyrosine kinase JBrowse link 20 44,436,354 44,630,316 RGD:6484113
G Git1 GIT ArfGAP 1 JBrowse link 10 62,656,000 62,664,467 RGD:6484113
G Hgf hepatocyte growth factor JBrowse link 4 15,435,460 15,505,377 RGD:6484113
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:6484113
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:6484113
G Iqgap1 IQ motif containing GTPase activating protein 1 JBrowse link 1 142,525,041 142,615,673 RGD:6484113
G Itgae integrin subunit alpha E JBrowse link 10 59,652,324 59,711,885 RGD:6484113
G Itgb7 integrin subunit beta 7 JBrowse link 7 143,820,236 143,837,802 RGD:6484113
G Jup junction plakoglobin JBrowse link 10 88,280,517 88,307,451 RGD:6484113
G Kifc3 kinesin family member C3 JBrowse link 19 10,305,405 10,339,186 RGD:6484113
G Klhl20 kelch-like family member 20 JBrowse link 13 78,912,361 78,957,226 RGD:6484113
G Lima1 LIM domain and actin binding 1 JBrowse link 7 141,428,113 141,528,447 RGD:6484113
G Lpp LIM domain containing preferred translocation partner in lipoma JBrowse link 11 79,192,603 79,827,858 RGD:6484113
G Mgat3 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase JBrowse link 7 121,394,541 121,436,935 RGD:6484113
G Myl2 myosin light chain 2 JBrowse link 12 39,951,863 39,959,065 RGD:6484113
G Myo6 myosin VI JBrowse link 8 87,583,649 87,731,271 RGD:6484113
G Nck1 NCK adaptor protein 1 JBrowse link 8 108,787,797 108,847,779 RGD:6484113
G Nckap1 NCK-associated protein 1 JBrowse link 3 67,725,180 67,804,680 RGD:6484113
G Nectin2 nectin cell adhesion molecule 2 JBrowse link 1 80,631,449 80,666,617 RGD:6484113
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 JBrowse link 10 81,657,152 81,666,542 RGD:6484113
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6484113
G Pip5k1a phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha JBrowse link 2 196,227,669 196,270,949 RGD:6484113
G Pip5k1c phosphatidylinositol-4-phosphate 5-kinase type 1 gamma JBrowse link 7 11,267,207 11,294,291 RGD:6484113
G Plcg1 phospholipase C, gamma 1 JBrowse link 3 156,727,642 156,758,307 RGD:6484113
G Plekha7 pleckstrin homology domain containing A7 JBrowse link 1 185,427,600 185,493,985 RGD:6484113
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:6484113
G Rap1a RAP1A, member of RAS oncogene family JBrowse link 2 208,193,950 208,215,186 RGD:6484113
G Rap1b RAP1B, member of RAS oncogene family JBrowse link 7 60,850,406 60,878,226 RGD:6484113
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:6484113
G Rock1 Rho-associated coiled-coil containing protein kinase 1 JBrowse link 18 1,273,490 1,390,790 RGD:6484113
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:6484113
G Stx4 syntaxin 4 JBrowse link 1 199,287,384 199,295,606 RGD:6484113
G Tiam1 TIAM Rac1 associated GEF 1 JBrowse link 11 29,931,083 30,061,173 RGD:6484113
G Tjp1 tight junction protein 1 JBrowse link 1 126,146,489 126,515,359 RGD:6484113
G Vasp vasodilator-stimulated phosphoprotein JBrowse link 1 80,170,608 80,185,882 RGD:6484113
G Vav2 vav guanine nucleotide exchange factor 2 JBrowse link 3 5,811,504 5,976,311 RGD:6484113
G Vcl vinculin JBrowse link 15 3,455,211 3,544,738 RGD:6484113
G Wasf2 WASP family member 2 JBrowse link 5 151,319,382 151,385,051 RGD:6484113
G Zyx zyxin JBrowse link 4 71,740,188 71,749,386 RGD:6484113

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  pathway 6015
    signaling pathway 2572
      cell adhesion signaling pathway 401
        cell-cell signaling pathway 246
          cadherin mediated signaling pathway 93
            classical cadherin signaling pathway 93
              E-cadherin signaling pathway 72
                altered E-cadherin signaling pathway 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.