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ONTOLOGY REPORT - ANNOTATIONS


Term:Chagas disease pathway
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Accession:PW:0001050 term browser browse the term
Definition:Trypanosoma cruzi is the causative agent of the Chagas disease, also known as the American trypanosomiasis, as it occurs primarily in poor areas of the Americas, mostly Central and South America. Infection interferes with a number of intracellular pathways and it appears to activate calcium signaling.
Synonyms:exact_synonym: American trypanosomiasis pathway;   Chagas' disease pathway;   Chagas-Mazza disease pathway;   South American trypanosomiasis pathway;   Trypanosoma cruzi infection pathway
 related_synonym: KEGG:05142


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Chagas disease pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 JBrowse link 11 105,967,948 105,989,964 RGD:6907045
G Adcy1 adenylate cyclase 1 JBrowse link 11 7,063,433 7,178,506 RGD:6907045
G Akt1 thymoma viral proto-oncogene 1 JBrowse link 12 112,653,821 112,674,884 RGD:6907045
G Akt2 thymoma viral proto-oncogene 2 JBrowse link 7 27,591,552 27,640,826 RGD:6907045
G Akt3 thymoma viral proto-oncogene 3 JBrowse link 1 177,020,076 177,261,781 RGD:6907045
G Bdkrb2 bradykinin receptor, beta 2 JBrowse link 12 105,563,172 105,595,244 RGD:6907045
G C1qa complement component 1, q subcomponent, alpha polypeptide JBrowse link 4 136,895,916 136,898,844 RGD:6907045
G C1qb complement component 1, q subcomponent, beta polypeptide JBrowse link 4 136,880,126 136,886,200 RGD:6907045
G C1qc complement component 1, q subcomponent, C chain JBrowse link 4 136,889,801 136,892,936 RGD:6907045
G C3 complement component 3 JBrowse link 17 57,203,967 57,228,136 RGD:6907045
G Calr calreticulin JBrowse link 8 84,842,088 84,846,931 RGD:6907045
G Casp8 caspase 8 JBrowse link 1 58,795,233 58,847,503 RGD:6907045
G Ccl3 chemokine (C-C motif) ligand 3 JBrowse link 11 83,647,843 83,649,378 RGD:6907045
G Ccl5 chemokine (C-C motif) ligand 5 JBrowse link 11 83,525,778 83,530,518 RGD:6907045
G Cd247 CD247 antigen JBrowse link 1 165,779,952 165,871,153 RGD:6907045
G Cd3d CD3 antigen, delta polypeptide JBrowse link 9 44,981,769 44,987,052 RGD:6907045
G Cd3e CD3 antigen, epsilon polypeptide JBrowse link 9 44,998,735 45,009,663 RGD:6907045
G Cd3g CD3 antigen, gamma polypeptide JBrowse link 9 44,969,572 44,980,431 RGD:6907045
G Cflar CASP8 and FADD-like apoptosis regulator JBrowse link 1 58,711,311 58,758,884 RGD:6907045
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 19 44,073,334 44,107,505 RGD:6907045
G Fadd Fas (TNFRSF6)-associated via death domain JBrowse link 7 144,578,323 144,582,441 RGD:6907045
G Fas Fas (TNF receptor superfamily member 6) JBrowse link 19 34,290,647 34,327,775 RGD:6907045
G Fasl Fas ligand (TNF superfamily, member 6) JBrowse link 1 161,780,691 161,788,495 RGD:6907045
G Fos FBJ osteosarcoma oncogene JBrowse link 12 85,473,890 85,477,274 RGD:6907045
G Gna11 guanine nucleotide binding protein, alpha 11 JBrowse link 10 81,528,724 81,545,162 RGD:6907045
G Gna14 guanine nucleotide binding protein, alpha 14 JBrowse link 19 16,435,667 16,610,818 RGD:6907045
G Gna15 guanine nucleotide binding protein, alpha 15 JBrowse link 10 81,502,313 81,524,447 RGD:6907045
G Gnai1 guanine nucleotide binding protein (G protein), alpha inhibiting 1 JBrowse link 5 18,265,135 18,360,413 RGD:6907045
G Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 JBrowse link 9 107,614,125 107,635,391 RGD:6907045
G Gnai3 guanine nucleotide binding protein (G protein), alpha inhibiting 3 JBrowse link 3 108,107,275 108,146,152 RGD:6907045
G Gnal guanine nucleotide binding protein, alpha stimulating, olfactory type JBrowse link 18 67,088,298 67,226,792 RGD:6907045
G Gnao1 guanine nucleotide binding protein, alpha O JBrowse link 8 93,810,153 93,969,388 RGD:6907045
G Gnaq guanine nucleotide binding protein, alpha q polypeptide JBrowse link 19 16,132,684 16,388,520 RGD:6907045
G Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus JBrowse link 2 174,284,320 174,346,744 RGD:6907045
G Ifnb1 interferon beta 1, fibroblast JBrowse link 4 88,522,025 88,522,794 RGD:6907045
G Ifng interferon gamma JBrowse link 10 118,441,046 118,445,894 RGD:6907045
G Ifngr1 interferon gamma receptor 1 JBrowse link 10 19,591,949 19,610,229 RGD:6907045
G Ifngr2 interferon gamma receptor 2 JBrowse link 16 91,547,059 91,564,007 RGD:6907045
G Ikbkb inhibitor of kappaB kinase beta JBrowse link 8 22,659,205 22,706,589 RGD:6907045
G Ikbkg inhibitor of kappaB kinase gamma JBrowse link X 74,393,233 74,456,792 RGD:6907045
G Il10 interleukin 10 JBrowse link 1 131,019,845 131,024,970 RGD:6907045
G Il12a interleukin 12a JBrowse link 3 68,690,644 68,698,550 RGD:6907045
G Il12b interleukin 12b JBrowse link 11 44,400,063 44,414,677 RGD:6907045
G Il1b interleukin 1 beta JBrowse link 2 129,364,569 129,371,164 RGD:6907045
G Il2 interleukin 2 JBrowse link 3 37,120,713 37,125,954 RGD:6907045
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:6907045
G Irak1 interleukin-1 receptor-associated kinase 1 JBrowse link X 74,013,914 74,023,921 RGD:6907045
G Irak4 interleukin-1 receptor-associated kinase 4 JBrowse link 15 94,543,613 94,568,317 RGD:6907045
G Jun jun proto-oncogene JBrowse link 4 95,049,036 95,052,222 RGD:6907045
G Map2k4 mitogen-activated protein kinase kinase 4 JBrowse link 11 65,688,244 65,788,359 RGD:6907045
G Mapk1 mitogen-activated protein kinase 1 JBrowse link 16 16,983,382 17,047,453 RGD:6907045
G Mapk10 mitogen-activated protein kinase 10 JBrowse link 5 102,908,547 103,212,604 RGD:6907045
G Mapk11 mitogen-activated protein kinase 11 JBrowse link 15 89,142,482 89,149,606 RGD:6907045
G Mapk12 mitogen-activated protein kinase 12 JBrowse link 15 89,130,584 89,141,577 RGD:6907045
G Mapk13 mitogen-activated protein kinase 13 JBrowse link 17 28,769,286 28,778,704 RGD:6907045
G Mapk14 mitogen-activated protein kinase 14 JBrowse link 17 28,691,342 28,748,405 RGD:6907045
G Mapk3 mitogen-activated protein kinase 3 JBrowse link 7 126,759,626 126,765,816 RGD:6907045
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 14 33,377,898 33,447,353 RGD:6907045
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 11 49,846,728 49,886,421 RGD:6907045
G Myd88 myeloid differentiation primary response gene 88 JBrowse link 9 119,335,934 119,340,018 RGD:6907045
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 JBrowse link 3 135,584,655 135,691,969 RGD:6907045
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha JBrowse link 12 55,489,409 55,492,647 RGD:6907045
G Nos2 nitric oxide synthase 2, inducible JBrowse link 11 78,920,787 78,960,226 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link 3 32,397,059 32,468,486 RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta JBrowse link 9 99,038,402 99,140,235 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta JBrowse link 4 149,649,168 149,702,566 RGD:6907045
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma JBrowse link 12 32,173,397 32,208,677 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 13 101,680,761 101,768,217 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 8 70,768,176 70,776,712 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 4 116,221,400 116,303,056 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase regulatory subunit 5 JBrowse link 11 68,432,125 68,497,849 RGD:6907045
G Plcb1 phospholipase C, beta 1 JBrowse link 2 134,786,164 135,475,258 RGD:6907045
G Plcb2 phospholipase C, beta 2 JBrowse link 2 118,705,003 118,728,661 RGD:6907045
G Plcb3 phospholipase C, beta 3 JBrowse link 19 6,953,708 6,975,006 RGD:6907045
G Plcb4 phospholipase C, beta 4 JBrowse link 2 135,658,603 136,014,602 RGD:6907045
G Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform JBrowse link 11 52,098,824 52,122,749 RGD:6907045
G Ppp2cb protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform JBrowse link 8 33,599,621 33,619,804 RGD:6907045
G Ppp2r1a protein phosphatase 2, regulatory subunit A, alpha JBrowse link 17 20,945,454 20,965,905 RGD:6907045
G Ppp2r1b protein phosphatase 2, regulatory subunit A, beta JBrowse link 9 50,856,896 50,899,325 RGD:6907045
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha JBrowse link 14 67,014,056 67,072,471 RGD:6907045
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta JBrowse link 18 42,645,221 43,059,471 RGD:6907045
G Ppp2r2c protein phosphatase 2, regulatory subunit B, gamma JBrowse link 5 36,866,846 36,955,078 RGD:6907045
G Ppp2r2d protein phosphatase 2, regulatory subunit B, delta JBrowse link 7 138,846,350 138,883,057 RGD:6907045
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) JBrowse link 19 5,637,442 5,648,134 RGD:6907045
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 JBrowse link 5 137,061,504 137,072,272 RGD:6907045
G Smad2 SMAD family member 2 JBrowse link 18 76,241,090 76,311,748 RGD:6907045
G Smad3 SMAD family member 3 JBrowse link 9 63,646,766 63,757,994 RGD:6907045
G Tgfb1 transforming growth factor, beta 1 JBrowse link 7 25,687,002 25,705,077 RGD:6907045
G Tgfb2 transforming growth factor, beta 2 JBrowse link 1 186,622,787 186,709,697 RGD:6907045
G Tgfb3 transforming growth factor, beta 3 JBrowse link 12 86,056,743 86,079,041 RGD:6907045
G Tgfbr1 transforming growth factor, beta receptor I JBrowse link 4 47,353,222 47,414,926 RGD:6907045
G Tgfbr2 transforming growth factor, beta receptor II JBrowse link 9 116,087,695 116,175,363 RGD:6907045
G Ticam1 toll-like receptor adaptor molecule 1 JBrowse link 17 56,269,462 56,276,767 RGD:6907045
G Tlr2 toll-like receptor 2 JBrowse link 3 83,836,272 83,841,824 RGD:6907045
G Tlr4 toll-like receptor 4 JBrowse link 4 66,827,551 66,846,581 RGD:6907045
G Tlr6 toll-like receptor 6 JBrowse link 5 64,952,030 64,970,942 RGD:6907045
G Tlr9 toll-like receptor 9 JBrowse link 9 106,222,598 106,226,876 RGD:6907045
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6907045
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a JBrowse link 6 125,349,723 125,362,483 RGD:6907045
G Traf6 TNF receptor-associated factor 6 JBrowse link 2 101,678,420 101,701,668 RGD:6907045

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  pathway 6011
    disease pathway 2078
      infectious disease pathway 588
        trypanosomiasis pathway 115
          Chagas disease pathway 100
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.