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ONTOLOGY REPORT - ANNOTATIONS


Term:ataxia telangiectasia-mutated (ATM) signaling pathway
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Accession:PW:0001361 term browser browse the term
Definition:The ataxia telangiectasia-mutated (ATM) serine/threonine kinase mediated signaling plays a major role in the response to DNA double strand breaks (DSB). Following lesion sensing by the MRN complex, ATM gets activated. Active ATM phosphorylates itself and targets resulting in triggering of DNA repair, cell cycle checkpoint and signaling pathways. While ATM signaling is best documented for its role in DSB responses, evidence accumulates that it functions in a range of other, DNA damage unrelated, responses.
Synonyms:exact_synonym: ATM signaling pathway

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ataxia telangiectasia-mutated (ATM) signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G R Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:8661225
RGD:8661232
G M Atm ataxia telangiectasia mutated JBrowse link 9 53,437,122 53,536,828 RGD:8661225
RGD:8661232
G H ATM ATM serine/threonine kinase JBrowse link 11 108,222,484 108,369,102 RGD:8661225
RGD:8661232
G R Baz1b bromodomain adjacent to zinc finger domain, 1B JBrowse link 12 24,478,882 24,536,851 RGD:8661242
G M Baz1b bromodomain adjacent to zinc finger domain, 1B JBrowse link 5 135,187,323 135,246,131 RGD:8661242
G H BAZ1B bromodomain adjacent to zinc finger domain 1B JBrowse link 7 73,440,406 73,522,293 RGD:8661242
G R Brca1 BRCA1, DNA repair associated JBrowse link 10 89,394,821 89,455,093 RGD:8661237
G M Brca1 breast cancer 1, early onset JBrowse link 11 101,488,761 101,551,955 RGD:8661237
G H BRCA1 BRCA1 DNA repair associated JBrowse link 17 43,044,295 43,125,364 RGD:8661237
G R Brcc3 BRCA1/BRCA2-containing complex, subunit 3 JBrowse link 9 9,863,380 9,865,920 RGD:8661242
G M Brcc3 BRCA1/BRCA2-containing complex, subunit 3 JBrowse link X 75,416,628 75,455,702 RGD:8661242
G H BRCC3 BRCA1/BRCA2-containing complex subunit 3 JBrowse link X 155,071,403 155,126,766 RGD:8661242
G R Eya1 EYA transcriptional coactivator and phosphatase 1 JBrowse link 5 4,275,728 4,495,525 RGD:8661242
G M Eya1 EYA transcriptional coactivator and phosphatase 1 JBrowse link 1 14,168,953 14,311,035 RGD:8661242
G H EYA1 EYA transcriptional coactivator and phosphatase 1 JBrowse link 8 71,197,433 71,548,104 RGD:8661242
G R Eya3 EYA transcriptional coactivator and phosphatase 3 JBrowse link 5 150,833,754 150,915,390 RGD:8661242
G M Eya3 EYA transcriptional coactivator and phosphatase 3 JBrowse link 4 132,639,025 132,724,765 RGD:8661242
G H EYA3 EYA transcriptional coactivator and phosphatase 3 JBrowse link 1 27,970,344 28,088,671 RGD:8661242
G R H2ax H2A.X variant histone JBrowse link 8 48,665,652 48,666,981 RGD:8661232
RGD:8661242
G M H2ax H2A.X variant histone JBrowse link 9 44,334,715 44,336,077 RGD:8661232
RGD:8661242
G H H2AX H2A.X variant histone JBrowse link 11 119,093,874 119,095,465 RGD:8661232
RGD:8661242
G R Kat5 lysine acetyltransferase 5 JBrowse link 1 220,967,795 220,974,596 RGD:8661225
RGD:8661232
G M Kat5 K(lysine) acetyltransferase 5 JBrowse link 19 5,603,014 5,611,556 RGD:8661225
RGD:8661232
G H KAT5 lysine acetyltransferase 5 JBrowse link 11 65,712,018 65,719,604 RGD:8661225
RGD:8661232
G R Kdm4a lysine demethylase 4A JBrowse link 5 136,967,650 137,014,402 RGD:8661237
RGD:8661242
G M Kdm4a lysine (K)-specific demethylase 4A JBrowse link 4 118,136,957 118,180,090 RGD:8661237
RGD:8661242
G H KDM4A lysine demethylase 4A JBrowse link 1 43,650,149 43,705,518 RGD:8661237
RGD:8661242
G R L3mbtl1 L3MBTL histone methyl-lysine binding protein 1 JBrowse link 3 159,316,580 159,348,914 RGD:8661237
RGD:8661242
G M L3mbtl1 L3MBTL1 histone methyl-lysine binding protein JBrowse link 2 162,942,333 162,977,806 RGD:8661237
RGD:8661242
G H L3MBTL1 L3MBTL histone methyl-lysine binding protein 1 JBrowse link 20 43,507,697 43,550,954 RGD:8661237
RGD:8661242
G R Mdc1 mediator of DNA damage checkpoint 1 JBrowse link 20 3,405,017 3,419,831 RGD:8661232
RGD:8661242
G M Mdc1 mediator of DNA damage checkpoint 1 JBrowse link 17 35,841,495 35,859,670 RGD:8661232
RGD:8661242
G H MDC1 mediator of DNA damage checkpoint 1 JBrowse link 6 30,699,807 30,717,988 RGD:8661232
RGD:8661242
G R Mre11 MRE11 homolog, double strand break repair nuclease JBrowse link 8 13,304,355 13,350,329 RGD:8661232
G H MRE11 MRE11 homolog, double strand break repair nuclease JBrowse link 11 94,415,570 94,512,701 RGD:8661232
G M Mre11a MRE11A homolog A, double strand break repair nuclease JBrowse link 9 14,784,654 14,837,125 RGD:8661232
G R Nbn nibrin JBrowse link 5 29,622,347 29,656,877 RGD:8661232
G M Nbn nibrin JBrowse link 4 15,957,587 15,992,589 RGD:8661232
G H NBN nibrin JBrowse link 8 89,933,331 89,984,724 RGD:8661232
G R Otub1 OTU deubiquitinase, ubiquitin aldehyde binding 1 JBrowse link 1 222,451,674 222,459,952 RGD:8661242
G M Otub1 OTU domain, ubiquitin aldehyde binding 1 JBrowse link 19 7,198,206 7,206,284 RGD:8661242
G H OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 JBrowse link 11 63,985,853 63,998,420 RGD:8661242
G R Pias1 protein inhibitor of activated STAT, 1 JBrowse link 8 67,771,720 67,869,015 RGD:8661242
G M Pias1 protein inhibitor of activated STAT 1 JBrowse link 9 62,878,366 62,980,879 RGD:8661242
G H PIAS1 protein inhibitor of activated STAT 1 JBrowse link 15 68,054,315 68,193,847 RGD:8661242
G R Pias4 protein inhibitor of activated STAT, 4 JBrowse link 7 11,414,565 11,428,090 RGD:8661242
G M Pias4 protein inhibitor of activated STAT 4 JBrowse link 10 81,153,961 81,167,720 RGD:8661242
G H PIAS4 protein inhibitor of activated STAT 4 JBrowse link 19 4,007,736 4,039,386 RGD:8661242
G R Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D JBrowse link 10 72,909,550 72,945,884 RGD:8661232
RGD:8661242
G M Ppm1d protein phosphatase 1D magnesium-dependent, delta isoform JBrowse link 11 85,311,254 85,347,071 RGD:8661232
RGD:8661242
G H PPM1D protein phosphatase, Mg2+/Mn2+ dependent 1D JBrowse link 17 60,600,187 60,666,280 RGD:8661232
RGD:8661242
G R Ppp2ca protein phosphatase 2 catalytic subunit alpha JBrowse link 10 37,534,449 37,554,861 RGD:8661232
RGD:8661242
G M Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform JBrowse link 11 52,098,824 52,122,749 RGD:8661232
RGD:8661242
G H PPP2CA protein phosphatase 2 catalytic subunit alpha JBrowse link 5 134,194,332 134,226,073 RGD:8661232
RGD:8661242
G R Ppp4c protein phosphatase 4, catalytic subunit JBrowse link 1 198,219,012 198,225,775 RGD:8661242
G M Ppp4c protein phosphatase 4, catalytic subunit JBrowse link 7 126,785,866 126,792,557 RGD:8661242
G H PPP4C protein phosphatase 4 catalytic subunit JBrowse link 16 30,075,994 30,085,377 RGD:8661242
G R Ppp5c protein phosphatase 5, catalytic subunit JBrowse link 1 78,944,054 78,968,361 RGD:8661232
G M Ppp5c protein phosphatase 5, catalytic subunit JBrowse link 7 17,004,640 17,027,914 RGD:8661232
G H PPP5C protein phosphatase 5 catalytic subunit JBrowse link 19 46,347,069 46,390,975 RGD:8661232
G R Ppp6c protein phosphatase 6, catalytic subunit JBrowse link 3 23,478,123 23,510,959 RGD:8661242
G M Ppp6c protein phosphatase 6, catalytic subunit JBrowse link 2 39,194,369 39,226,349 RGD:8661242
G H PPP6C protein phosphatase 6 catalytic subunit JBrowse link 9 125,146,573 125,189,939 RGD:8661242
G R Psmd14 proteasome 26S subunit, non-ATPase 14 JBrowse link 3 47,578,449 47,673,330 RGD:8661242
G M Psmd14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 JBrowse link 2 61,711,694 61,800,376 RGD:8661242
G H PSMD14 proteasome 26S subunit, non-ATPase 14 JBrowse link 2 161,308,425 161,411,717 RGD:8661242
G R Pwwp3a PWWP domain containing 3A, DNA repair factor JBrowse link 7 12,331,288 12,348,263 RGD:8661237
G M Pwwp3a PWWP domain containing 3A, DNA repair factor JBrowse link 10 80,226,431 80,245,144 RGD:8661237
G H PWWP3A PWWP domain containing 3A, DNA repair factor JBrowse link 19 1,354,959 1,378,429 RGD:8661237
G R Rad50 RAD50 double strand break repair protein JBrowse link 10 39,002,130 39,054,042 RGD:8661232
G M Rad50 RAD50 double strand break repair protein JBrowse link 11 53,649,519 53,707,319 RGD:8661232
G H RAD50 RAD50 double strand break repair protein JBrowse link 5 132,556,977 132,646,349 RGD:8661232
G R Rbbp8 RB binding protein 8, endonuclease JBrowse link 18 3,134,630 3,227,702 RGD:8661237
G M Rbbp8 retinoblastoma binding protein 8, endonuclease JBrowse link 18 11,633,276 11,743,207 RGD:8661237
G H RBBP8 RB binding protein 8, endonuclease JBrowse link 18 22,914,121 23,026,486 RGD:8661237
G R Rif1 replication timing regulatory factor 1 JBrowse link 3 37,599,540 37,648,818 RGD:8661237
G M Rif1 replication timing regulatory factor 1 JBrowse link 2 52,072,815 52,126,769 RGD:8661237
G H RIF1 replication timing regulatory factor 1 JBrowse link 2 151,409,902 151,534,200 RGD:8661237
G R Rnf168 ring finger protein 168 JBrowse link 11 71,721,242 71,743,421 RGD:8661232
RGD:8661237
G M Rnf168 ring finger protein 168 JBrowse link 16 32,277,461 32,301,442 RGD:8661232
RGD:8661237
G H RNF168 ring finger protein 168 JBrowse link 3 196,468,783 196,503,768 RGD:8661232
RGD:8661237
G R Rnf20 ring finger protein 20 JBrowse link 5 64,892,996 64,920,397 RGD:8661225
G M Rnf20 ring finger protein 20 JBrowse link 4 49,632,005 49,656,887 RGD:8661225
G H RNF20 ring finger protein 20 JBrowse link 9 101,533,853 101,563,344 RGD:8661225
G R Rnf4 ring finger protein 4 JBrowse link 14 81,658,400 81,679,756 RGD:8661242
G M Rnf4 ring finger protein 4 JBrowse link 5 34,336,250 34,353,445 RGD:8661242
G H RNF4 ring finger protein 4 JBrowse link 4 2,469,106 2,515,859 RGD:8661242
G R Rnf40 ring finger protein 40 JBrowse link 1 199,037,472 199,052,823 RGD:8661225
G M Rnf40 ring finger protein 40 JBrowse link 7 127,588,698 127,603,605 RGD:8661225
G H RNF40 ring finger protein 40 JBrowse link 16 30,761,612 30,800,231 RGD:8661225
G R Rnf8 ring finger protein 8 JBrowse link 20 8,285,380 8,309,858 RGD:8661232
RGD:8661237
G M Rnf8 ring finger protein 8 JBrowse link 17 29,614,789 29,641,664 RGD:8661232
RGD:8661237
G H RNF8 ring finger protein 8 JBrowse link 6 37,353,983 37,394,734 RGD:8661232
RGD:8661237
G R Tp53bp1 tumor protein p53 binding protein 1 JBrowse link 3 113,160,030 113,259,701 RGD:8661237
G H TP53BP1 tumor protein p53 binding protein 1 JBrowse link 15 43,403,061 43,510,640 RGD:8661237
G R Trip12 thyroid hormone receptor interactor 12 JBrowse link 9 92,305,059 92,435,388 RGD:8661242
G M Trip12 thyroid hormone receptor interactor 12 JBrowse link 1 84,721,189 84,850,004 RGD:8661242
G H TRIP12 thyroid hormone receptor interactor 12 JBrowse link 2 229,763,837 229,923,234 RGD:8661242
G M Trp53bp1 transformation related protein 53 binding protein 1 JBrowse link 2 121,194,835 121,296,354 RGD:8661237
G R Ube2n ubiquitin-conjugating enzyme E2N JBrowse link 7 36,610,147 36,640,190 RGD:8661232
RGD:8661237
G M Ube2n ubiquitin-conjugating enzyme E2N JBrowse link 10 95,515,162 95,545,658 RGD:8661232
RGD:8661237
G H UBE2N ubiquitin conjugating enzyme E2 N JBrowse link 12 93,405,684 93,442,336 RGD:8661232
RGD:8661237
G R Ubr5 ubiquitin protein ligase E3 component n-recognin 5 JBrowse link 7
7
76,789,110
76,839,661
76,835,517
76,907,441
RGD:8661242
G M Ubr5 ubiquitin protein ligase E3 component n-recognin 5 JBrowse link 15 37,967,328 38,078,862 RGD:8661242
G H UBR5 ubiquitin protein ligase E3 component n-recognin 5 JBrowse link 8 102,252,273 102,412,700 RGD:8661242
G R Usp16 ubiquitin specific peptidase 16 JBrowse link 11 27,101,213 27,130,345 RGD:8661242
G M Usp16 ubiquitin specific peptidase 16 JBrowse link 16 87,454,985 87,483,515 RGD:8661242
G H USP16 ubiquitin specific peptidase 16 JBrowse link 21 29,024,617 29,054,488 RGD:8661242
G R Usp3 ubiquitin specific peptidase 3 JBrowse link 8 72,207,970 72,284,871 RGD:8661242
G M Usp3 ubiquitin specific peptidase 3 JBrowse link 9 66,514,639 66,593,148 RGD:8661242
G H USP3 ubiquitin specific peptidase 3 JBrowse link 15 63,504,511 63,594,640 RGD:8661242
G R Usp44 ubiquitin specific peptidase 44 JBrowse link 7 34,714,293 34,759,352 RGD:8661242
G M Usp44 ubiquitin specific peptidase 44 JBrowse link 10 93,819,969 93,859,425 RGD:8661242
G H USP44 ubiquitin specific peptidase 44 JBrowse link 12 95,516,560 95,551,529 RGD:8661242
G R Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:8661237
RGD:8661242
G M Vcp valosin containing protein JBrowse link 4 42,979,964 43,000,507 RGD:8661237
RGD:8661242
G H VCP valosin containing protein JBrowse link 9 35,056,064 35,072,668 RGD:8661237
RGD:8661242

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 29473
    regulatory pathway 15906
      pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis 7024
        DNA damage response pathway 1250
          ataxia telangiectasia-mutated (ATM) signaling pathway 117
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.