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Term:tranexamic acid pharmacodynamics pathway
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Accession:PW:0001788 term browser browse the term
Definition:The pathway of tranexamic acid-target interaction and of the biochemical or physiological responses to drug. It is an inhibitor of plasminogen and used to treat bleeding conditions and in surgery to prevent excessive bleeding Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00287

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tranexamic acid pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:10402751
G F10 coagulation factor X JBrowse link 16 81,803,169 81,822,476 RGD:10402751
G F11 coagulation factor XI JBrowse link 16 50,179,458 50,201,644 RGD:10402751
G F12 coagulation factor XII JBrowse link 17 9,736,577 9,744,420 RGD:10402751
G F13a1 coagulation factor XIII A1 chain JBrowse link 17 28,504,650 28,680,015 RGD:10402751
G F13b coagulation factor XIII B chain JBrowse link 13 56,598,891 56,623,132 RGD:10402751
G F2 coagulation factor II JBrowse link 3 80,529,468 80,542,993 RGD:10402751
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:10402751
G F5 coagulation factor V JBrowse link 13 82,479,997 82,535,540 RGD:10402751
G F7 coagulation factor VII JBrowse link 16 81,824,610 81,834,923 RGD:10402751
G F8 coagulation factor VIII JBrowse link 18 367,862 399,242 RGD:10402751
G F9 coagulation factor IX JBrowse link X 143,097,507 143,141,791 RGD:10402751
G Fga fibrinogen alpha chain JBrowse link 2 181,997,562 182,013,726 RGD:10402751
G Fgb fibrinogen beta chain JBrowse link 2 182,028,044 182,035,026 RGD:10402751
G Fgg fibrinogen gamma chain JBrowse link 2 181,987,080 181,994,523 RGD:10402751
G Ggcx gamma-glutamyl carboxylase JBrowse link 4 100,277,345 100,293,097 RGD:10402751
G Klkb1 kallikrein B1 JBrowse link 16 50,151,127 50,175,407 RGD:10402751
G Plat plasminogen activator, tissue type JBrowse link 16 74,098,263 74,122,897 RGD:10402751
G Plg plasminogen JBrowse link 1 48,521,828 48,563,895 RGD:10402751
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 JBrowse link 1 199,338,785 199,341,306 RGD:10402751

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Path 1
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  pathway 6063
    drug pathway 394
      blood and blood forming organs drug pathway 59
        antihemorrhagic drug pathway 20
          tranexamic acid drug pathway 20
            tranexamic acid pharmacodynamics pathway 20
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.