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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:tranexamic acid pharmacodynamics pathway
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Accession:PW:0001788 term browser browse the term
Definition:The pathway of tranexamic acid-target interaction and of the biochemical or physiological responses to drug. It is an inhibitor of plasminogen and used to treat bleeding conditions and in surgery to prevent excessive bleeding Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00287


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tranexamic acid pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a1 collagen, type I, alpha 1 ISO SMPDB SMP:00287 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G F10 coagulation factor X ISO SMPDB SMP:00287 NCBI chr 8:13,037,308...13,056,676
Ensembl chr 8:13,037,308...13,056,676
JBrowse link
G F11 coagulation factor XI ISO SMPDB SMP:00287 NCBI chr 8:45,240,659...45,262,055
Ensembl chr 8:45,241,174...45,262,031
JBrowse link
G F12 coagulation factor XII (Hageman factor) ISO SMPDB SMP:00287 NCBI chr13:55,417,958...55,426,804
Ensembl chr13:55,417,958...55,426,793
JBrowse link
G F13a1 coagulation factor XIII, A1 subunit ISO SMPDB SMP:00287 NCBI chr13:36,867,178...37,050,244
Ensembl chr13:36,867,178...37,050,244
JBrowse link
G F13b coagulation factor XIII, beta subunit ISO SMPDB SMP:00287 NCBI chr 1:139,501,547...139,523,758
Ensembl chr 1:139,501,702...139,523,752
JBrowse link
G F2 coagulation factor II ISO SMPDB SMP:00287 NCBI chr 2:91,612,397...91,636,457
Ensembl chr 2:91,625,320...91,636,414
JBrowse link
G F3 coagulation factor III ISO SMPDB SMP:00287 NCBI chr 3:121,723,537...121,735,052
Ensembl chr 3:121,723,537...121,735,048
JBrowse link
G F5 coagulation factor V ISO SMPDB SMP:00287 NCBI chr 1:164,151,835...164,220,277
Ensembl chr 1:164,151,838...164,220,277
JBrowse link
G F7 coagulation factor VII ISO SMPDB SMP:00287 NCBI chr 8:13,025,506...13,035,809
Ensembl chr 8:13,026,034...13,035,809
JBrowse link
G F8 coagulation factor VIII ISO SMPDB SMP:00287 NCBI chr  X:75,170,344...75,382,738
Ensembl chr  X:75,172,715...75,382,615
JBrowse link
G F9 coagulation factor IX ISO SMPDB SMP:00287 NCBI chr  X:59,999,329...60,030,760
Ensembl chr  X:59,999,464...60,030,759
JBrowse link
G Fga fibrinogen alpha chain ISO SMPDB SMP:00287 NCBI chr 3:83,026,153...83,033,627
Ensembl chr 3:83,026,076...83,033,627
JBrowse link
G Fgb fibrinogen beta chain ISO SMPDB SMP:00287 NCBI chr 3:83,042,246...83,049,863
Ensembl chr 3:83,040,141...83,049,863
JBrowse link
G Fgg fibrinogen gamma chain ISO SMPDB SMP:00287 NCBI chr 3:83,007,724...83,015,056
Ensembl chr 3:83,007,724...83,015,049
JBrowse link
G Ggcx gamma-glutamyl carboxylase ISO SMPDB SMP:00287 NCBI chr 6:72,414,279...72,433,359
Ensembl chr 6:72,414,308...72,430,712
JBrowse link
G Klkb1 kallikrein B, plasma 1 ISO SMPDB SMP:00287 NCBI chr 8:45,266,688...45,294,835
Ensembl chr 8:45,266,689...45,294,859
JBrowse link
G Plat plasminogen activator, tissue ISO SMPDB SMP:00287 NCBI chr 8:22,757,722...22,782,848
Ensembl chr 8:22,757,727...22,782,844
JBrowse link
G Plg plasminogen ISO SMPDB SMP:00287 NCBI chr17:12,378,609...12,419,384
Ensembl chr17:12,378,608...12,419,385
JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 ISO SMPDB SMP:00287 NCBI chr 7:127,893,063...127,895,658
Ensembl chr 7:127,886,227...127,895,454
Ensembl chr 7:127,886,227...127,895,454
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6067
    drug pathway 400
      blood and blood forming organs drug pathway 65
        antihemorrhagic drug pathway 20
          tranexamic acid drug pathway 20
            tranexamic acid pharmacodynamics pathway 20
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.