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ONTOLOGY REPORT - ANNOTATIONS


Term:spironolactone pharmacodynamics pathway
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Accession:PW:0001824 term browser browse the term
Definition:The pathway of spironolactone-target interaction and of the biochemical or physiological responses to drug. The drug inhibits the effects of aldosterone by competing with its receptor. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00134


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spironolactone pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aqp1 aquaporin 1 JBrowse link 6 55,336,299 55,348,555 RGD:10402751
G Aqp2 aquaporin 2 JBrowse link 15 99,579,056 99,584,545 RGD:10402751
G Aqp3 aquaporin 3 JBrowse link 4 41,092,724 41,098,183 RGD:10402751
G Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide JBrowse link 3 101,576,219 101,604,707 RGD:10402751
G Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide JBrowse link 1 172,271,709 172,298,064 RGD:10402751
G Atp1a3 ATPase, Na+/K+ transporting, alpha 3 polypeptide JBrowse link 7 24,978,165 25,006,077 RGD:10402751
G Atp1a4 ATPase, Na+/K+ transporting, alpha 4 polypeptide JBrowse link 1 172,223,508 172,258,424 RGD:10402751
G Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide JBrowse link 1 164,437,099 164,458,355 RGD:10402751
G Atp1b2 ATPase, Na+/K+ transporting, beta 2 polypeptide JBrowse link 11 69,599,728 69,605,978 RGD:10402751
G Atp1b3 ATPase, Na+/K+ transporting, beta 3 polypeptide JBrowse link 9 96,332,655 96,364,431 RGD:10402751
G Atp1b4 ATPase, (Na+)/K+ transporting, beta 4 polypeptide JBrowse link X 38,316,122 38,336,784 RGD:10402751
G Clcnka chloride channel, voltage-sensitive Ka JBrowse link 4 141,384,611 141,398,706 RGD:10402751
G Fxyd2 FXYD domain-containing ion transport regulator 2 JBrowse link 9 45,399,709 45,410,278 RGD:10402751
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 JBrowse link 8 76,898,083 77,245,012 RGD:10402751
G Scnn1a sodium channel, nonvoltage-gated 1 alpha JBrowse link 6 125,314,271 125,344,943 RGD:10402751
G Scnn1b sodium channel, nonvoltage-gated 1 beta JBrowse link 7 121,865,038 121,918,728 RGD:10402751
G Scnn1g sodium channel, nonvoltage-gated 1 gamma JBrowse link 7 121,734,420 121,768,482 RGD:10402751
G Slc12a1 solute carrier family 12, member 1 JBrowse link 2 125,152,510 125,230,002 RGD:10402751
G Slc12a3 solute carrier family 12, member 3 JBrowse link 8 94,329,109 94,366,222 RGD:10402751
G Slc12a6 solute carrier family 12, member 6 JBrowse link 2 112,266,314 112,363,163 RGD:10402751
G Slc14a2 solute carrier family 14 (urea transporter), member 2 JBrowse link 18 78,146,144 78,596,950 RGD:10402751
G Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 JBrowse link 19 28,835,135 28,913,960 RGD:10402751
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 JBrowse link 17 12,584,189 12,628,489 RGD:10402751
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 JBrowse link 19 8,617,996 8,628,299 RGD:10402751
G Slc38a4 solute carrier family 38, member 4 JBrowse link 15 96,994,816 97,055,956 RGD:10402751
G Slc3a1 solute carrier family 3, member 1 JBrowse link 17 85,028,347 85,064,241 RGD:10402751
G Slc3a2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 JBrowse link 19 8,706,882 8,723,369 RGD:10402751
G Slc6a20b solute carrier family 6 (neurotransmitter transporter), member 20B JBrowse link 9 123,593,823 123,632,538 RGD:10402751
G Slc7a5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 JBrowse link 8 121,881,146 121,907,686 RGD:10402751
G Slc7a6 solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 JBrowse link 8 106,168,219 106,198,714 RGD:10402751
G Slc7a7 solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 JBrowse link 14 54,369,442 54,420,068 RGD:10402751
G Slc7a8 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 JBrowse link 14 54,722,215 54,781,886 RGD:10402751
G Slc7a9 solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 JBrowse link 7 35,448,727 35,466,034 RGD:10402751

Term paths to the root
Path 1
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  pathway 6011
    drug pathway 396
      cardiovascular system drug pathway 181
        diuretic drug pathway 33
          spironolactone drug pathway 33
            spironolactone pharmacodynamics pathway 33
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.