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ONTOLOGY REPORT - ANNOTATIONS


Term:acebutolol pharmacodynamics pathway
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Accession:PW:0002171 term browser browse the term
Definition:The pathway of acebutolol-target interaction and of the biochemical or physiological responses to drug. The drug is a selective antagonist of beta adrenergic type 1 receptor. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00296


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acebutolol pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc8 ATP binding cassette subfamily C member 8 JBrowse link NW_004936528 1,608,782 1,682,873 RGD:9068941
G Abcc9 ATP binding cassette subfamily C member 9 JBrowse link NW_004936548 4,983,461 5,110,693 RGD:9068941
G Adrb1 adrenoceptor beta 1 JBrowse link NW_004936486 4,400,467 4,401,588 RGD:9068941
G Agtr1 angiotensin II receptor type 1 JBrowse link NW_004936519 6,831,096 6,873,977 RGD:9068941
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 JBrowse link NW_004936627 1,555,151 1,584,370 RGD:9068941
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 JBrowse link NW_004936706 476,473 494,659 RGD:9068941
G Atp1a4 ATPase Na+/K+ transporting subunit alpha 4 JBrowse link NW_004936740 445,952 478,580 RGD:9068941
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 JBrowse link NW_004936481 17,438,146 17,460,329 RGD:9068941
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 JBrowse link NW_004936595 908,019 914,426 RGD:9068941
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 JBrowse link NW_004936540 3,621,656 3,640,885 RGD:9068941
G Atp1b4 ATPase Na+/K+ transporting family member beta 4 JBrowse link NW_004936479 9,648,315 9,666,782 RGD:9068941
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 JBrowse link NW_004936558 3,300,941 3,357,595 RGD:9068941
G Cacna1c calcium voltage-gated channel subunit alpha1 C JBrowse link NW_004936606 2,168,104 2,867,560 RGD:9068941
G Cacna1g calcium voltage-gated channel subunit alpha1 G JBrowse link NW_004936490 11,093,600 11,157,756 RGD:9068941
G Cacna1h calcium voltage-gated channel subunit alpha1 H JBrowse link NW_004936694 2,702,224 2,724,574 RGD:9068941
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 JBrowse link NW_004936529 1,889,811 2,023,710 RGD:9068941
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 JBrowse link NW_004936490 14,448,305 14,468,785 RGD:9068941
G Chrm2 cholinergic receptor muscarinic 2 JBrowse link NW_004936592 1,396,939 1,525,255 RGD:9068941
G Dlg1 discs large MAGUK scaffold protein 1 JBrowse link NW_004936833 551,989 843,064 RGD:9068941
G Fxyd2 FXYD domain containing ion transport regulator 2 JBrowse link NW_004936542 2,956,784 2,961,076 RGD:9068941
G Hcn4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 JBrowse link NW_004936471 32,527,551 32,570,548 RGD:9068941
G Itpr1 inositol 1,4,5-trisphosphate receptor type 1 JBrowse link NW_004936577 3,896,455 4,198,396 RGD:9068941
G Kcnd3 potassium voltage-gated channel subfamily D member 3 JBrowse link NW_004936690 417,907 627,025 RGD:9068941
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 JBrowse link NW_004936500 7,998,464 8,007,848 RGD:9068941
G Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 JBrowse link NW_004936500 8,067,009 8,072,383 RGD:9068941
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link NW_004936527 6,380,222 6,412,390 RGD:9068941
G Kcnip2 potassium voltage-gated channel interacting protein 2 JBrowse link NW_004936600 3,940,806 3,974,455 RGD:9068941
G Kcnj11 potassium inwardly rectifying channel subfamily J member 11 JBrowse link NW_004936528 1,685,015 1,688,220 RGD:9068941
G Kcnj2 potassium inwardly rectifying channel subfamily J member 2 JBrowse link NW_004936655 3,447,026 3,459,569 RGD:9068941
G Kcnj3 potassium inwardly rectifying channel subfamily J member 3 JBrowse link NW_004936469 23,163,057 23,304,178 RGD:9068941
G Kcnj4 potassium inwardly rectifying channel subfamily J member 4 JBrowse link NW_004936492 2,865,803 2,867,657 RGD:9068941
G Kcnj5 potassium inwardly rectifying channel subfamily J member 5 JBrowse link NW_004936572 3,344,942 3,373,690 RGD:9068941
G Kcnj8 potassium inwardly rectifying channel subfamily J member 8 JBrowse link NW_004936548 5,125,583 5,132,490 RGD:9068941
G Kcnk1 potassium two pore domain channel subfamily K member 1 JBrowse link NW_004936484 18,186,184 18,221,304 RGD:9068941
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 JBrowse link NW_004936794 707,122 994,206 RGD:9068941
G LOC101966570 sodium/potassium-transporting ATPase subunit alpha-2 JBrowse link NW_004936740 489,357 514,235 RGD:9068941
G LOC101967074 calmodulin JBrowse link NW_004936488 17,580,425 17,588,480 RGD:9068941
G Mylk myosin light chain kinase JBrowse link NW_004936725 1,418,930 1,594,697 RGD:9068941
G Plcb1 phospholipase C beta 1 JBrowse link NW_004936485 10,548,966 11,254,139 RGD:9068941
G Pln phospholamban JBrowse link NW_004936658 1,443,626 1,453,770 RGD:9068941
G Prkaca protein kinase cAMP-activated catalytic subunit alpha JBrowse link NW_004936659 2,750,015 2,765,914 RGD:9068941
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha JBrowse link NW_004936541 7,845,876 7,863,677 RGD:9068941
G Ryr2 ryanodine receptor 2 JBrowse link NW_004936484 15,402,488 15,825,410 RGD:9068941
G Scn5a sodium voltage-gated channel alpha subunit 5 JBrowse link NW_004936473 27,883,526 27,963,994 RGD:9068941
G Slc8a1 solute carrier family 8 member A1 JBrowse link NW_004936508 10,894,918 11,256,084 RGD:9068941
G Snta1 syntrophin alpha 1 JBrowse link NW_004936561 7,101,654 7,134,529 RGD:9068941
G Sntb1 syntrophin beta 1 JBrowse link NW_004936470 26,074,175 26,301,076 RGD:9068941
G Sntb2 syntrophin beta 2 JBrowse link NW_004936475 19,335,584 19,425,642 RGD:9068941
G Tnnc1 troponin C1, slow skeletal and cardiac type JBrowse link NW_004936473 3,290,961 3,293,920 RGD:9068941
G Tnnc2 troponin C2, fast skeletal type JBrowse link NW_004936514 7,196,576 7,199,603 RGD:9068941
G Tnni1 troponin I1, slow skeletal type JBrowse link NW_004936567 3,013,359 3,025,137 RGD:9068941
G Tnni2 troponin I2, fast skeletal type JBrowse link NW_004936816 738,754 741,328 RGD:9068941
G Tnni3 troponin I3, cardiac type JBrowse link NW_004936886 437,754 440,925 RGD:9068941
G Tnnt1 troponin T1, slow skeletal type JBrowse link NW_004936886 425,331 434,546 RGD:9068941
G Tnnt2 troponin T2, cardiac type JBrowse link NW_004936567 3,052,167 3,069,077 RGD:9068941
G Tnnt3 troponin T3, fast skeletal type JBrowse link NW_004936816 805,360 822,044 RGD:9068941
G Tpm1 tropomyosin 1 JBrowse link NW_004936471 23,643,645 23,670,775 RGD:9068941
G Tpm2 tropomyosin 2 JBrowse link NW_004936524 3,679,719 3,687,828 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5482
    drug pathway 357
      cardiovascular system drug pathway 165
        adrenergic beta receptor antagonist drug pathway 59
          adrenergic beta receptor selective antagonist drug pathway 58
            acebutolol drug pathway 58
              acebutolol pharmacodynamics pathway 58
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.