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ONTOLOGY REPORT - ANNOTATIONS


Term:bupivacaine pharmacodynamics pathway
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Accession:PW:0002194 term browser browse the term
Definition:The pathway of bupivacaine-target interaction and of the biochemical or physiological responses to drug. It acts mainly as a voltage-gated sodium channel blocker. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00393


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bupivacaine pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adra1a adrenoceptor alpha 1A JBrowse link 15 43,296,997 43,398,314 RGD:10402751
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 JBrowse link 2 204,003,742 204,032,023 RGD:10402751
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 JBrowse link 13 90,651,682 90,676,629 RGD:10402751
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 JBrowse link 1 81,852,423 81,881,565 RGD:10402751
G Atp1a4 ATPase Na+/K+ transporting subunit alpha 4 JBrowse link 13 90,605,792 90,642,032 RGD:10402751
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 JBrowse link 13 82,737,161 82,757,681 RGD:10402751
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 JBrowse link 10 56,205,622 56,211,879 RGD:10402751
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 JBrowse link 8 104,190,032 104,221,342 RGD:10402751
G Atp1b4 ATPase Na+/K+ transporting family member beta 4 JBrowse link X 124,631,544 124,652,520 RGD:10402751
G Cacna1a calcium voltage-gated channel subunit alpha1 A JBrowse link 19 25,453,236 25,749,550 RGD:10402751
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 JBrowse link 8 116,154,661 116,285,643 RGD:10402751
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 JBrowse link 10 85,954,138 85,974,764 RGD:10402751
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit JBrowse link 3 176,533,182 176,547,965 RGD:10402751
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit JBrowse link 2 189,088,570 189,096,785 RGD:10402751
G Drd1 dopamine receptor D1 JBrowse link 17 11,099,736 11,104,352 RGD:10402751
G Fxyd2 FXYD domain-containing ion transport regulator 2 JBrowse link 8 49,710,334 49,717,492 RGD:10402751
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 JBrowse link 3 2,507,745 2,534,664 RGD:10402751
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A JBrowse link 10 5,707,806 6,123,568 RGD:10402751
G Grin3a glutamate ionotropic receptor NMDA type subunit 3A JBrowse link 5 64,928,620 65,073,012 RGD:10402751
G Htr1a 5-hydroxytryptamine receptor 1A JBrowse link 2 36,246,628 36,247,896 RGD:10402751
G Kcnd2 potassium voltage-gated channel subfamily D member 2 JBrowse link 4 48,309,283 48,816,804 RGD:10402751
G Kcnip2 potassium voltage-gated channel interacting protein 2 JBrowse link 1 265,549,610 265,573,393 RGD:10402751
G Oprm1 opioid receptor, mu 1 JBrowse link 1 43,454,803 43,704,948 RGD:10402751
G Pcsk2 proprotein convertase subtilisin/kexin type 2 JBrowse link 3 137,618,891 137,923,385 RGD:10402751
G Pomc proopiomelanocortin JBrowse link 6 28,382,937 28,388,771 RGD:10402751
G Scn10a sodium voltage-gated channel alpha subunit 10 JBrowse link 8 128,298,593 128,416,896 RGD:10402751
G Scn1b sodium voltage-gated channel beta subunit 1 JBrowse link 1 89,550,738 89,560,469 RGD:10402751
G Slc6a2 solute carrier family 6 member 2 JBrowse link 19 15,391,682 15,431,274 RGD:10402751
G Slc6a3 solute carrier family 6 member 3 JBrowse link 1 32,323,011 32,363,983 RGD:10402751
G Slc6a4 solute carrier family 6 member 4 JBrowse link 10 63,153,656 63,188,377 RGD:10402751

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  pathway 6016
    drug pathway 393
      nervous system drug pathway 181
        anesthetic drug pathway 78
          bupivacaine drug pathway 30
            bupivacaine pharmacodynamics pathway 30
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.