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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:mexiletine pharmacodynamics pathway
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Accession:PW:0002339 term browser browse the term
Definition:The pathway of mexiletine-target interaction and of the biochemical or physiological responses to drug. The drug is a non-selective voltage-gated sodium channel blocker antiarrhythmic agent. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00329


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mexiletine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 ISO SMPDB SMP:00329 NCBI chrNW_004955414:32,216,243...32,289,028 JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 ISO SMPDB SMP:00329 NCBI chrNW_004955413:17,385,966...17,510,220 JBrowse link
G Adrb1 adrenoceptor beta 1 ISO SMPDB SMP:00329 NCBI chrNW_004955431:19,025,663...19,027,026 JBrowse link
G Agtr1 angiotensin II receptor type 1 ISO SMPDB SMP:00329 NCBI chrNW_004955474:8,733,942...8,781,305 JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 ISO SMPDB SMP:00329 NCBI chrNW_004955435:19,537,224...19,563,631 JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 ISO SMPDB SMP:00329 NCBI chrNW_004955468:11,898,786...11,924,341 JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 ISO SMPDB SMP:00329 NCBI chrNW_004955555:869,508...892,510 JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 ISO SMPDB SMP:00329 NCBI chrNW_004955462:8,072,519...8,095,311 JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 ISO SMPDB SMP:00329 NCBI chrNW_004955467:9,261,775...9,268,743 JBrowse link
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 ISO SMPDB SMP:00329 NCBI chrNW_004955508:3,848,745...3,875,992 JBrowse link
G Atp1b4 ATPase Na+/K+ transporting family member beta 4 ISO SMPDB SMP:00329 NCBI chrNW_004955572:1,507,290...1,524,359 JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO SMPDB SMP:00329 NCBI chrNW_004955482:7,233,336...7,295,754 JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO SMPDB SMP:00329 NCBI chrNW_004955454:4,573,647...5,199,046 JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G ISO SMPDB SMP:00329 NCBI chrNW_004955451:11,136,885...11,194,321 JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H ISO SMPDB SMP:00329 NCBI chrNW_004955442:16,047,965...16,108,862 JBrowse link
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 ISO SMPDB SMP:00329 NCBI chrNW_004955532:2,163,529...2,283,509 JBrowse link
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 ISO SMPDB SMP:00329 NCBI chrNW_004955451:14,041,848...14,059,740 JBrowse link
G Calm1 calmodulin 1 ISO SMPDB SMP:00329 NCBI chrNW_004955438:12,842,437...12,854,028 JBrowse link
G Chrm2 cholinergic receptor muscarinic 2 ISO SMPDB SMP:00329 NCBI chrNW_004955494:5,845,581...5,975,614 JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 ISO SMPDB SMP:00329 NCBI chrNW_004955420:13,068,289...13,273,805 JBrowse link
G Fxyd2 FXYD domain containing ion transport regulator 2 ISO SMPDB SMP:00329 NCBI chrNW_004955412:19,039,635...19,046,172 JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 ISO SMPDB SMP:00329 NCBI chrNW_004955450:4,139,852...4,181,377 JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 ISO SMPDB SMP:00329 NCBI chrNW_004955413:2,835,730...2,838,761 JBrowse link
G Kcnd3 potassium voltage-gated channel subfamily D member 3 ISO SMPDB SMP:00329 NCBI chrNW_004955435:15,227,386...15,431,136 JBrowse link
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 ISO SMPDB SMP:00329 NCBI chrNW_004955407:33,807,581...33,814,356 JBrowse link
G Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 ISO SMPDB SMP:00329 NCBI chrNW_004955407:33,734,969...33,736,609 JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 ISO SMPDB SMP:00329 NCBI chrNW_004955491:5,391,444...5,422,241 JBrowse link
G Kcnip2 potassium voltage-gated channel interacting protein 2 ISO SMPDB SMP:00329 NCBI chrNW_004955485:8,468,117...8,472,220 JBrowse link
G Kcnj11 potassium inwardly rectifying channel subfamily J member 11 ISO SMPDB SMP:00329 NCBI chrNW_004955414:32,209,426...32,212,424 JBrowse link
G Kcnj2 potassium inwardly rectifying channel subfamily J member 2 ISO SMPDB SMP:00329 NCBI chrNW_004955478:2,734,795...2,745,217 JBrowse link
G Kcnj3 potassium inwardly rectifying channel subfamily J member 3 ISO SMPDB SMP:00329 NCBI chrNW_004955440:19,716,081...19,836,957 JBrowse link
G Kcnj4 potassium inwardly rectifying channel subfamily J member 4 ISO SMPDB SMP:00329 NCBI chrNW_004955413:24,605,887...24,634,524 JBrowse link
G Kcnj5 potassium inwardly rectifying channel subfamily J member 5 ISO SMPDB SMP:00329 NCBI chrNW_004955412:29,850,097...29,874,213 JBrowse link
G Kcnj8 potassium inwardly rectifying channel subfamily J member 8 ISO SMPDB SMP:00329 NCBI chrNW_004955413:17,364,447...17,371,255 JBrowse link
G Kcnk1 potassium two pore domain channel subfamily K member 1 ISO SMPDB SMP:00329 NCBI chrNW_004955492:5,805,170...5,846,402 JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 ISO SMPDB SMP:00329 NCBI chrNW_004955422:14,212,563...14,544,556 JBrowse link
G Mylk myosin light chain kinase ISO SMPDB SMP:00329 NCBI chrNW_004955427:22,760,432...23,008,432 JBrowse link
G Plcb1 phospholipase C beta 1 ISO SMPDB SMP:00329 NCBI chrNW_004955415:18,210,608...18,915,099 JBrowse link
G Pln phospholamban ISO SMPDB SMP:00329 NCBI chrNW_004955436:1,439,098...1,447,070 JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha ISO SMPDB SMP:00329 NCBI chrNW_004955415:32,794,172...32,807,944 JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha ISO SMPDB SMP:00329 NCBI chrNW_004955478:4,241,283...4,262,119 JBrowse link
G Ryr2 ryanodine receptor 2 ISO SMPDB SMP:00329 NCBI chrNW_004955492:2,647,597...3,275,512 JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO SMPDB SMP:00329 NCBI chrNW_004955427:25,295,517...25,371,419 JBrowse link
G Slc8a1 solute carrier family 8 member A1 ISO SMPDB SMP:00329 NCBI chrNW_004955441:7,653,107...8,037,784 JBrowse link
G Snta1 syntrophin alpha 1 ISO SMPDB SMP:00329 NCBI chrNW_004955422:27,844,699...27,872,104 JBrowse link
G Sntb1 syntrophin beta 1 ISO SMPDB SMP:00329 NCBI chrNW_004955417:25,906,013...26,128,134 JBrowse link
G Sntb2 syntrophin beta 2 ISO SMPDB SMP:00329 NCBI chrNW_004955484:7,391,076...7,489,357 JBrowse link
G Tnnc1 troponin C1, slow skeletal and cardiac type ISO SMPDB SMP:00329 NCBI chrNW_004955430:2,438,644...2,441,596 JBrowse link
G Tnnc2 troponin C2, fast skeletal type ISO SMPDB SMP:00329 NCBI chrNW_004955445:11,466,579...11,469,123 JBrowse link
G Tnni1 troponin I1, slow skeletal type ISO SMPDB SMP:00329 NCBI chrNW_004955406:37,535,397...37,554,868 JBrowse link
G Tnni2 troponin I2, fast skeletal type ISO SMPDB SMP:00329 NCBI chrNW_004955422:13,649,827...13,652,342 JBrowse link
G Tnni3 troponin I3, cardiac type ISO SMPDB SMP:00329 NCBI chrNW_004955567:1,037,325...1,042,102 JBrowse link
G Tnnt1 troponin T1, slow skeletal type ISO SMPDB SMP:00329 NCBI chrNW_004955567:1,039,625...1,050,581 JBrowse link
G Tnnt2 troponin T2, cardiac type ISO SMPDB SMP:00329 NCBI chrNW_004955406:37,491,462...37,507,360 JBrowse link
G Tnnt3 troponin T3, fast skeletal type ISO SMPDB SMP:00329 NCBI chrNW_004955422:13,702,015...13,718,915 JBrowse link
G Tpm1 tropomyosin 1 ISO SMPDB SMP:00329 NCBI chrNW_004955450:12,197,241...12,223,372 JBrowse link
G Tpm2 tropomyosin 2 ISO SMPDB SMP:00329 NCBI chrNW_004955472:611,079...617,823 JBrowse link

Term paths to the root
Path 1
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  pathway 3928
    drug pathway 348
      cardiovascular system drug pathway 162
        antiarrhythmic drug pathway 90
          mexiletine drug pathway 57
            mexiletine pharmacodynamics pathway 57
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.