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Term:phenindione pharmacodynamics pathway
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Accession:PW:0002494 term browser browse the term
Definition:The pathway of phenindione-target interaction and of the biochemical or physiological responses to drug. Phenindione is used as anticoagulant that antagonizes the vitamin K dependent clotting pathway. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00655

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phenindione pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G COL1A1 collagen type I alpha 1 chain JBrowse link 17 49,149,277 49,166,833 RGD:9068941
G F10 coagulation factor X JBrowse link 13 113,332,124 113,358,660 RGD:9068941
G F11 coagulation factor XI JBrowse link 4 190,643,733 190,666,512 RGD:9068941
G F12 coagulation factor XII JBrowse link 5 179,766,089 179,773,854 RGD:9068941
G F13A1 coagulation factor XIII A chain JBrowse link 6 6,159,012 6,337,000 RGD:9068941
G F13B coagulation factor XIII B chain JBrowse link 1 176,938,155 176,965,609 RGD:9068941
G F2 coagulation factor II, thrombin JBrowse link 11 47,227,891 47,249,157 RGD:9068941
G F3 coagulation factor III, tissue factor JBrowse link 1 95,918,359 95,931,050 RGD:9068941
G F5 coagulation factor V JBrowse link 1 148,718,748 148,791,049 RGD:9068941
G F7 coagulation factor VII JBrowse link 13 113,315,868 113,329,995 RGD:9068941
G F8 coagulation factor VIII JBrowse link X 154,156,864 154,345,635 RGD:9068941
G F9 coagulation factor IX JBrowse link X 138,934,144 138,967,180 RGD:9068941
G FGA fibrinogen alpha chain JBrowse link 4 158,767,782 158,775,414 RGD:9068941
G FGB fibrinogen beta chain JBrowse link 4 158,747,659 158,755,766 RGD:9068941
G FGG fibrinogen gamma chain JBrowse link 4 158,788,761 158,797,460 RGD:9068941
G GGCX gamma-glutamyl carboxylase JBrowse link 2A 87,152,108 87,164,567 RGD:9068941
G KLKB1 kallikrein B1 JBrowse link 4 190,604,901 190,636,300 RGD:9068941
G PLAT plasminogen activator, tissue type JBrowse link 8 38,864,918 38,897,776 RGD:9068941
G PLG plasminogen JBrowse link 6 163,674,142 163,722,630 RGD:9068941
G VKORC1 vitamin K epoxide reductase complex subunit 1 JBrowse link 16 31,459,556 31,464,617 RGD:9068941

Term paths to the root
Path 1
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  pathway 5624
    drug pathway 378
      blood and blood forming organs drug pathway 58
        antithrombotic drug pathway 58
          anticoagulant drug pathway 27
            vitamin K antagonist drug pathway 26
              phenindione drug pathway 20
                phenindione pharmacodynamics pathway 20
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.