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Term:phenindione pharmacodynamics pathway
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Accession:PW:0002494 term browser browse the term
Definition:The pathway of phenindione-target interaction and of the biochemical or physiological responses to drug. Phenindione is used as anticoagulant that antagonizes the vitamin K dependent clotting pathway. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00655

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phenindione pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G COL1A1 collagen type I alpha 1 chain JBrowse link 9 26,183,852 26,199,927 RGD:9068941
G F10 coagulation factor X JBrowse link 22 60,585,563 60,597,027 RGD:9068941
G F11 coagulation factor XI JBrowse link 16 44,469,609 44,492,833 RGD:9068941
G F12 coagulation factor XII JBrowse link 4 35,950,642 35,968,137 RGD:9068941
G F13A1 coagulation factor XIII A chain JBrowse link 35 6,186,750 6,347,522 RGD:9068941
G F13B coagulation factor XIII B chain JBrowse link 7 5,674,458 5,700,928 RGD:9068941
G F2 coagulation factor II, thrombin JBrowse link 18 42,782,744 42,799,531 RGD:9068941
G F3 coagulation factor III, tissue factor JBrowse link 6 54,709,581 54,720,603 RGD:9068941
G F5 coagulation factor V JBrowse link 7 28,999,481 29,069,603 RGD:9068941
G F7 coagulation factor VII JBrowse link 22 60,572,459 60,582,743 RGD:9068941
G F8 coagulation factor VIII JBrowse link X 122,894,974 123,046,343 RGD:9068941
G F9 coagulation factor IX JBrowse link X 109,501,341 109,533,798 RGD:9068941
G FGA fibrinogen alpha chain JBrowse link 15 52,238,305 52,247,017 RGD:9068941
G FGB fibrinogen beta chain JBrowse link 15 52,220,690 52,228,526 RGD:9068941
G FGG fibrinogen gamma chain JBrowse link 15 52,261,215 52,270,077 RGD:9068941
G GGCX gamma-glutamyl carboxylase JBrowse link 17 39,512,293 39,525,251 RGD:9068941
G KLKB1 kallikrein B1 JBrowse link 16 44,492,735 44,517,854 RGD:9068941
G PLAT plasminogen activator, tissue type JBrowse link 16 23,469,590 23,496,013 RGD:9068941
G PLG plasminogen JBrowse link 1 49,497,229 49,535,260 RGD:9068941
G VKORC1 vitamin K epoxide reductase complex subunit 1 JBrowse link 6 17,140,565 17,142,621 RGD:9068941

Term paths to the root
Path 1
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  pathway 5643
    drug pathway 374
      blood and blood forming organs drug pathway 56
        antithrombotic drug pathway 56
          anticoagulant drug pathway 25
            vitamin K antagonist drug pathway 24
              phenindione drug pathway 20
                phenindione pharmacodynamics pathway 20
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.