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Term:phenindione pharmacodynamics pathway
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Accession:PW:0002494 term browser browse the term
Definition:The pathway of phenindione-target interaction and of the biochemical or physiological responses to drug. Phenindione is used as anticoagulant that antagonizes the vitamin K dependent clotting pathway. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00655

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phenindione pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G COL1A1 collagen type I alpha 1 chain JBrowse link 12 26,379,087 26,397,180 RGD:9068941
G F10 coagulation factor X JBrowse link 11 78,521,760 78,538,256 RGD:9068941
G F11 coagulation factor XI JBrowse link 17 9,045,990 9,073,552 RGD:9068941
G F12 coagulation factor XII JBrowse link 2 80,527,451 80,544,835 RGD:9068941
G F13A1 coagulation factor XIII A chain JBrowse link 7 3,751,290 3,900,797 RGD:9068941
G F13B coagulation factor XIII B chain RGD:9068941
G F2 coagulation factor II, thrombin JBrowse link 2 15,793,257 15,819,151 RGD:9068941
G F3 coagulation factor III, tissue factor JBrowse link 4 122,827,018 122,837,673 RGD:9068941
G F5 coagulation factor V JBrowse link 4 81,403,273 81,484,908 RGD:9068941
G F7 coagulation factor VII JBrowse link 11 78,512,389 78,518,668 RGD:9068941
G F8 coagulation factor VIII JBrowse link X 125,265,330 125,350,853 RGD:9068941
G F9 coagulation factor IX JBrowse link X 114,218,704 114,250,436 RGD:9068941
G FGA fibrinogen alpha chain JBrowse link 8 74,574,870 74,584,202 RGD:9068941
G FGB fibrinogen beta chain JBrowse link 8 74,598,170 74,607,409 RGD:9068941
G FGG fibrinogen gamma chain JBrowse link 8 74,553,040 74,562,151 RGD:9068941
G GGCX gamma-glutamyl carboxylase JBrowse link 3 59,202,363 59,219,807 RGD:9068941
G KLKB1 kallikrein B1 JBrowse link 15 47,071,581 47,100,272 RGD:9068941
G PLAT plasminogen activator, tissue type JBrowse link 17 11,195,599 11,223,821 RGD:9068941
G PLG plasminogen JBrowse link 1 7,062,399 7,109,521 RGD:9068941
G VKORC1 vitamin K epoxide reductase complex subunit 1 JBrowse link 3 17,386,230 17,389,162 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5636
    drug pathway 381
      blood and blood forming organs drug pathway 55
        antithrombotic drug pathway 55
          anticoagulant drug pathway 25
            vitamin K antagonist drug pathway 24
              phenindione drug pathway 20
                phenindione pharmacodynamics pathway 20
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.