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Term:phenindione pharmacodynamics pathway
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Accession:PW:0002494 term browser browse the term
Definition:The pathway of phenindione-target interaction and of the biochemical or physiological responses to drug. Phenindione is used as anticoagulant that antagonizes the vitamin K dependent clotting pathway. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00655

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phenindione pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Col1a1 collagen type I alpha 1 chain JBrowse link NW_004936490 11,448,552 11,465,836 RGD:9068941
G F11 coagulation factor XI JBrowse link NW_004936554 3,205,539 3,223,228 RGD:9068941
G F12 coagulation factor XII JBrowse link NW_004936597 1,687,511 1,694,782 RGD:9068941
G F13a1 coagulation factor XIII A chain JBrowse link NW_004936534 6,199,066 6,360,374 RGD:9068941
G F13b coagulation factor XIII B chain JBrowse link NW_004936567 6,712,666 6,735,539 RGD:9068941
G F2 coagulation factor II, thrombin JBrowse link NW_004936562 2,371,725 2,388,617 RGD:9068941
G F3 coagulation factor III, tissue factor JBrowse link NW_004936537 4,637,028 4,647,915 RGD:9068941
G F5 coagulation factor V JBrowse link NW_004936481 17,114,441 17,178,902 RGD:9068941
G F7 coagulation factor VII JBrowse link NW_004936472 505,751 515,375 RGD:9068941
G F8 coagulation factor VIII JBrowse link NW_004936927 189,359 301,791 RGD:9068941
G F9 coagulation factor IX JBrowse link NW_004936513 8,052,998 8,090,245 RGD:9068941
G Fga fibrinogen alpha chain JBrowse link NW_004936576 1,322,406 1,329,743 RGD:9068941
G Fgb fibrinogen beta chain JBrowse link NW_004936576 1,306,076 1,313,485 RGD:9068941
G Fgg fibrinogen gamma chain JBrowse link NW_004936576 1,343,657 1,352,085 RGD:9068941
G Ggcx gamma-glutamyl carboxylase JBrowse link NW_004936712 1,696,264 1,709,087 RGD:9068941
G Klkb1 kallikrein B1 JBrowse link NW_004936554 3,227,395 3,256,710 RGD:9068941
G LOC101961866 coagulation factor X JBrowse link NW_004936472 475,851 502,341 RGD:9068941
G Plat plasminogen activator, tissue type JBrowse link NW_004936785 476,200 503,371 RGD:9068941
G Plg plasminogen JBrowse link NW_004936489 11,775,243 11,808,482 RGD:9068941
G Vkorc1 vitamin K epoxide reductase complex subunit 1 JBrowse link NW_004936501 13,459,400 13,461,864 RGD:9068941

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Path 1
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  pathway 5483
    drug pathway 357
      blood and blood forming organs drug pathway 48
        antithrombotic drug pathway 48
          anticoagulant drug pathway 23
            vitamin K antagonist drug pathway 22
              phenindione drug pathway 20
                phenindione pharmacodynamics pathway 20
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.