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ONTOLOGY REPORT - ANNOTATIONS


Term:carvedilol pharmacodynamics pathway
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Accession:PW:0002587 term browser browse the term
Definition:The pathway of carvedilol-target interaction and of the biochemical or physiological responses to drug. The drug is non-selective blocker of adrenergic receptor beta belonging to the third generation of blockers. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00367


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carvedilol pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABCC8 ATP binding cassette subfamily C member 8 JBrowse link 21 39,963,001 40,037,040 RGD:9068941
G ABCC9 ATP binding cassette subfamily C member 9 JBrowse link 27 25,199,580 25,352,637 RGD:9068941
G ADRA1A adrenoceptor alpha 1A JBrowse link 25 30,690,959 30,801,484 RGD:9068941
G ADRB1 adrenoceptor beta 1 JBrowse link 28 24,908,224 24,909,684 RGD:9068941
G AGTR1 angiotensin II receptor type 1 JBrowse link 23 43,569,658 43,617,113 RGD:9068941
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 JBrowse link 17 53,828,482 53,847,043 RGD:9068941
G ATP1A3 ATPase Na+/K+ transporting subunit alpha 3 JBrowse link 1 112,325,988 112,346,056 RGD:9068941
G ATP1A4 ATPase Na+/K+ transporting subunit alpha 4 JBrowse link 38 22,023,176 22,080,656 RGD:9068941
G ATP1B1 ATPase Na+/K+ transporting subunit beta 1 JBrowse link 7 29,464,132 29,487,124 RGD:9068941
G ATP1B2 ATPase Na+/K+ transporting subunit beta 2 JBrowse link 5 32,548,591 32,553,911 RGD:9068941
G ATP1B3 ATPase Na+/K+ transporting subunit beta 3 JBrowse link 23 37,684,507 37,727,535 RGD:9068941
G ATP1B4 ATPase Na+/K+ transporting family member beta 4 JBrowse link X 92,347,443 92,368,206 RGD:9068941
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 JBrowse link 26 8,148,181 8,209,392 RGD:9068941
G CACNA1C calcium voltage-gated channel subunit alpha1 C JBrowse link 27 44,007,363 44,748,251 RGD:9068941
G CACNA1G calcium voltage-gated channel subunit alpha1 G JBrowse link 9 26,481,148 26,544,511 RGD:9068941
G CACNA1H calcium voltage-gated channel subunit alpha1 H JBrowse link 6 39,510,129 39,533,129 RGD:9068941
G CACNA2D2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 JBrowse link 20 38,859,047 38,995,239 RGD:9068941
G CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 JBrowse link 9 23,182,407 23,197,035 RGD:9068941
G CALM1 calmodulin 1 JBrowse link 8 61,398,231 61,408,874 RGD:9068941
G CHRM2 cholinergic receptor muscarinic 2 JBrowse link 16 11,515,727 11,665,651 RGD:9068941
G DLG1 discs large MAGUK scaffold protein 1 JBrowse link 33 30,016,323 30,253,180 RGD:9068941
G FXYD2 FXYD domain containing ion transport regulator 2 JBrowse link 5 15,812,335 15,824,552 RGD:9068941
G HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 JBrowse link 30 36,637,492 36,656,194 RGD:9068941
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 JBrowse link 20 12,746,171 13,065,256 RGD:9068941
G KCNA5 potassium voltage-gated channel subfamily A member 5 JBrowse link 27 39,808,987 39,810,789 RGD:9068941
G KCND3 potassium voltage-gated channel subfamily D member 3 JBrowse link 17 63,470,829 63,668,354 RGD:9068941
G KCNE1 potassium voltage-gated channel subfamily E regulatory subunit 1 JBrowse link 31 29,858,428 29,868,315 RGD:9068941
G KCNE2 potassium voltage-gated channel subfamily E regulatory subunit 2 JBrowse link 31 29,777,154 29,777,839 RGD:9068941
G KCNH2 potassium voltage-gated channel subfamily H member 2 JBrowse link 16 15,009,031 15,041,786 RGD:9068941
G KCNIP2 potassium voltage-gated channel interacting protein 2 JBrowse link 28 14,409,526 14,425,641 RGD:9068941
G KCNJ11 potassium inwardly rectifying channel subfamily J member 11 JBrowse link 21 39,953,461 39,957,615 RGD:9068941
G KCNJ2 potassium inwardly rectifying channel subfamily J member 2 JBrowse link 9 16,468,938 16,475,722 RGD:9068941
G KCNJ3 potassium inwardly rectifying channel subfamily J member 3 JBrowse link 36 1,354,686 1,496,397 RGD:9068941
G KCNJ4 potassium inwardly rectifying channel subfamily J member 4 JBrowse link 10 26,321,274 26,348,978 RGD:9068941
G KCNJ5 potassium inwardly rectifying channel subfamily J member 5 JBrowse link 5 5,736,544 5,760,705 RGD:9068941
G KCNJ8 potassium inwardly rectifying channel subfamily J member 8 JBrowse link 27 25,368,565 25,375,754 RGD:9068941
G KCNK1 potassium two pore domain channel subfamily K member 1 JBrowse link 4 6,117,406 6,139,390 RGD:9068941
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 JBrowse link 18 46,554,390 46,830,533 RGD:9068941
G MYLK myosin light chain kinase JBrowse link 33 26,663,991 26,867,370 RGD:9068941
G PLCB1 phospholipase C beta 1 JBrowse link 24 13,337,285 13,996,218 RGD:9068941
G PLN phospholamban JBrowse link 1 58,579,095 58,590,541 RGD:9068941
G PRKACA protein kinase cAMP-activated catalytic subunit alpha JBrowse link 20 48,416,730 48,425,237 RGD:9068941
G PRKAR1A protein kinase cAMP-dependent type I regulatory subunit alpha JBrowse link 9 15,180,940 15,203,035 RGD:9068941
G RYR2 ryanodine receptor 2 JBrowse link 4 2,371,868 2,908,132 RGD:9068941
G SCN5A sodium voltage-gated channel alpha subunit 5 JBrowse link 23 8,278,844 8,374,614 RGD:9068941
G SLC8A1 solute carrier family 8 member A1 JBrowse link 17 32,004,207 32,381,399 RGD:9068941
G SNTA1 syntrophin alpha 1 JBrowse link 24 22,636,716 22,665,828 RGD:9068941
G SNTB1 syntrophin beta 1 JBrowse link 13 19,394,608 19,627,278 RGD:9068941
G SNTB2 syntrophin beta 2 JBrowse link 5 80,345,331 80,461,559 RGD:9068941
G TNNC1 troponin C1, slow skeletal and cardiac type JBrowse link 20 37,313,983 37,317,288 RGD:9068941
G TNNC2 troponin C2, fast skeletal type JBrowse link 24 33,136,644 33,139,289 RGD:9068941
G TNNI1 troponin I1, slow skeletal type JBrowse link 7 1,647,138 1,658,648 RGD:9068941
G TNNI2 troponin I2, fast skeletal type JBrowse link 18 46,076,816 46,079,362 RGD:9068941
G TNNI3 troponin I3, cardiac type JBrowse link 1 102,475,146 102,478,319 RGD:9068941
G TNNT1 troponin T1, slow skeletal type JBrowse link 1 102,479,617 102,490,776 RGD:9068941
G TNNT2 troponin T2, cardiac type JBrowse link 7 1,598,306 1,620,531 RGD:9068941
G TNNT3 troponin T3, fast skeletal type JBrowse link 18 46,131,925 46,148,577 RGD:9068941
G TPM1 tropomyosin 1 JBrowse link 30 27,636,407 27,664,907 RGD:9068941
G TPM2 tropomyosin 2 JBrowse link 11 52,212,372 52,219,947 RGD:9068941

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Term Annotations click to browse term
  pathway 5643
    drug pathway 374
      cardiovascular system drug pathway 175
        adrenergic beta receptor antagonist drug pathway 59
          adrenergic beta receptor non-selective antagonist drug pathway 59
            carvedilol drug pathway 59
              carvedilol pharmacodynamics pathway 59
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.