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Term:
Parent Terms Term With Siblings Child Terms
dicarboxylic acid +     
ibuprofen +   
(+)-DCA-CC 
(+-)-chartaceone C 
(+-)-chartaceone D 
(+-)-chartaceone E 
(+-)-chartaceone F 
(-)-DCA-CC 
(13R)-13-dihydrocarminomycin 
(13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid 
(13R)-S-cysteinylglycinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid 
(1R,2S)-nortilidine +  
(1S,2R)-nortilidine +  
(2E)-2-(methoxycarbonylmethyl)but-2-enedioic acid 
(2E)-3-(methoxycarbonyl)pent-2-enedioic acid 
(2R,4S)-2-[(1R)-1-carboxy-2-hydroxy-2-methylpropyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid 
(2R,4S)-2-[(1S)-1-carboxy-2-hydroxy-2-methylpropyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid 
(2R,4S)-2-[(1S)-1-carboxy-2-hydroxyethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid 
(2S)-2-(4-\{[(1R,2S)-2-hydroxycyclopentyl]methyl\}phenyl)propanoic acid 
(2S,3R)-cis-caftaric acid 
(2S,3R)-trans-caftaric acid 
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid 
(2S,4S,5R)-1-(4-tert-butylbenzoyl)-2-isobutyl-5-(1,3-thiazol-2-yl)pyrrolidine-2,4-dicarboxylic acid 
(2S,4S,5R)-2-isobutyl-5-(2-thienyl)-1-[4-(trifluoromethyl)benzoyl]pyrrolidine-2,4-dicarboxylic acid 
(3R,4R)-1-[(1S)-carboxy-2-(methylsulfinyl)ethyl]-3-[(5S)-5-amino-5-carboxypentanamido]-4-sulfanylazetidin-2-one 
(5-hydroxyindol-3-yl)acetic acid  
(5S)-5-(carboxymethyl)-L-proline 
(5S)-5-[(2S)-2-amino-2-carboxyethyl]-4,5-dihydroisoxazole-3-carboxylic acid 
(6-methoxy-2-naphthyl)acetic acid 
(6R,7R)-7-[[(2R)-2-carboxy-2-(4-hydroxyphenyl)-1-oxoethyl]amino]-7-methoxy-3-[[(1-methyl-5-tetrazolyl)thio]methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
(7S)-2-[(carboxycarbonyl)amino]-7-\{[(1,1-dioxido-1,2-benzothiazol-3-yl)oxy]methyl\}-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid 
(8S)-cystein-S-yl-(7R,17S)-dihydroxy-(4Z,9,11,13Z,15E,19Z)-docosahexaenoic acid 
(8S)-glycinylcystein-S-yl-(7R,17S)-dihydroxy-(4Z,9,11,13Z,15E,19Z)-docosahexaenoic acid 
(E)-3-methylglutaconic acid +  
(E,E)-bilirubin 
(R)-2-(phosphonomethyl)malic acid 
(Z)-3-hydroxydec-2-enedioic acid 
1',4-dihydroxymidazolam 
1,1,1,3,3,3-hexafluoropropan-2-ol  
1,2-Dihydrophthalic acid 
1,4-cyclohexanedicarboxylic acid 
1-(2,4-dichlorophenyl)-5-methyl-4,5-dihydro-1H-pyrazole-3,5-dicarboxylic acid +  
1-(3-chlorophenyl)piperazine  
1-(carboxymethyl)cyclohexane-1-carboxylic acid 
1-hydroxymidazolam +   
1-hydroxymidazolam beta-D-glucuronide  
10,11-trans-dihydroxy-10,11-dihydrocarbamazepine +  
12-hydroxynevirapine 
15-oxo-beta-bilirubin 
16(S)-cystein-S-yl,17(R)-hydroxy-(4Z,7Z,10,12,14,19Z)-docosahexaenoic acid 
16(S)-glycinylcystein-S-yl-17(R)-hydroxy-(4Z,7Z,10,12,14,19Z)-docosahexaenoic acid 
2'-(S-L-cysteinyl)-L-histidine 
2,2'-[(2-amino-2-oxoethyl)imino]diacetic acid 
2,3-Methylenesuccinic acid 
2,5-bis(5-carboxy-3-ethyl-4-methylpyrrol-2-ylmethyl)-3,4-diethylpyrrole 
2,5-diimino-3,4-bis(indol-3-yl)hexanedioic acid 
2,5-diphenylfuran-3,4-dicarboxylic acid 
2,6-dimethylaniline +   
2-(2-carboxyethyl)-4-methyl-5-propylfuran-3-carboxylic acid 
2-(4'-Methylthio)butylmalic acid 
2-(5'-Methylthio)pentylmalic acid 
2-(6'-Methylthio)hexylmalic acid 
2-(7'-Methylthio)heptylmalic acid 
2-(acetamidomethylidene)succinic acid 
2-(carboxymethyl)-1-oxo-1,2-dihydronaphtho[1,2-d]-1,2-thiazole-4-carboxylic acid 3,3-dioxide 
2-(ethoxyimino)-2-ketoglutaric acid 
2-(omega-methylthio)alkylmaleic acid +  
2-(p-coumaroyl)malic acid 
2-(phosphinomethylidene)succinic acid 
2-amino-2-deoxyisochorismic acid 
2-benzylsuccinic acid +  
2-formylbenzoic acid 
2-formylglutaric acid 
2-Hydroxy-2-ethylsuccinic acid 
2-hydroxydicarboxylic acid +   
2-hydroxyibuprofen 
2-hydroxymethylglutaric acid +  
2-isopropylmaleic acid 
2-isopropylmalic acid +  
2-methoxyacetaminophen glucuronide 
2-methoxyacetaminophen glucuronide(1-) 
2-methoxyacetaminophen sulfate 
2-methoxyacetaminophen sulfate(1-) 
2-methylbutanedioic acid +  
2-methylene-3-methylsuccinic acid 
2-methylideneglutaric acid 
2-Oxo-5-methyl-cis-muconate 
2-Oxosuberate 
2-Propylglutaric acid 
2-propylmalic acid +  
2-Propylsuccinic acid 
2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid +  
2-succinylbenzoic acid +  
20-hydroxy-20-oxoleukotriene B4-20-(beta-D-glucuronide) 
3'-hydroxy-4'-methoxydiclofenac 
3'-hydroxydiclofenac 
3,4-bis(7-chloroindol-3-yl)-2,5-diiminohexanedioic acid 
3,4-dihydroxymandelic acid  
3,5-dihydroxyphenylacetic acid 
3-(1-carboxyvinyloxy)anthranilic acid 
3-(2'-Methylthio)ethylmalic acid 
3-(3'-Methylthio)propylmalic acid 
3-(4'-Methylthio)butylmalic acid 
3-(5'-Methylthio)pentylmalic acid 
3-(6'-Methylthio)hexylmalic acid 
3-(7'-Methylthio)heptylmalic acid 
3-(acetamidomethylidene)-2-(hydroxymethyl)succinic acid 
3-[(1-carboxyvinyl)oxy]benzoic acid 
3-chlorobenzoic acid 
3-hydroxy-2,2-dimethylbutyric acid 
3-hydroxy-3-methylglutaric acid +  
3-hydroxymethylantipyrine 
3-hydroxysuberic acid 
3-methylmalic acid +  
3-O-vanillyceanothic acid 
3-propylmalic acid 
4',5-dihydroxydiclofenac 
4'-hydroxydiclofenac  
4,4'-disulfanyldibutanoic acid 
4-(2-carboxyethyl)-7a-methyl-1-oxo-octahydro-1H-indene-5-carboxylic acid glucuronide 
4-(acetylamino)-3-hydroxyphenyl hydrogen sulfate 
4-(acetylamino)-3-hydroxyphenyl sulfate 
4-(methylamino)antipyrine 
4-(trifluoromethyl)phenol 
4-acetamidoantipyrine 
4-amino-4-deoxyprephenic acid 
4-aminoantipyrine 
4-aminofolic acid 
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal 
4-ethoxyaniline +   
4-formylaminoantipyrine 
4-hydroxy-2,6-dimethylaniline 
4-hydroxy-6-methylaniline 
4-hydroxymidazolam +   
4-hydroxymidazolam beta-D-glucuronide 
4-hydroxypropofol 
4E,15Z-bilirubin IXa 
5'-hydroxyomeprazole  
5,6,6'-trihydroxy-5'-methoxy[biphenyl]-3,3'-dicarboxylic acid 
5-(6-O-malonyl-beta-D-glucosyloxy)-indole-3-carboxylic acid 
5-[(1-carboxyethenyl)oxy]-6-hydroxycyclohexa-1,3-diene-1-carboxylic acid +  
5-carboxy-2'-deoxyuridine 
5-fluorouridine 5'-monophosphate 
5-hydroxydiclofenac  
5-hydroxydiclofenac quinone imine 
5-O-desmethyldonepezil 
5-oxo-delta-bilirubin 
6-(carboxymethoxy)hexanoic acid 
6-\{[1-(benzylsulfonyl)piperidin-4-yl]amino\}-3-(carboxymethoxy)thieno[3,2-b][1]benzothiophene-2-carboxylic acid 
6-azauridine +   
7-(2-amino-2-carboxyethyl)-5-hydroxy-2H-1,4-benzothiazine-3-carboxylic acid 
7-hydroxyticlopidine 
8,5'-diferulic acid 
8-hydroxy-2-oxabicyclo[3.3.1]non-6-ene-3,5-dicarboxylic acid 
\{4-[(carboxymethoxy)carbonyl]-3,3-dioxido-1-oxonaphtho[1,2-d]-1,2-thiazol-2(1H)-yl\}acetic acid 
acetaminophen O-beta-D-glucosiduronic acid  
acetohydrazide +   
ACT-132577 +   
ACT-333679 +  
actinorhodin 
adefovir +   
adxanthromycin A 
adxanthromycin B 
aldaric acid +   
alizarin complexone 
alloxanthine +   
alpha,omega-dicarboxylic acid +   
alpha-Allokainic acid 
amino dicarboxylic acid +   
anaerobilin 
aripiprazole  
aryl(methyl)malonic acid +  
atenolol acid 
atenolol-desisopropyl 
ATTO 565 +  
ATTO 565 meta-isomer(1+) +  
ATTO 565 para-isomer(1+) +  
ATTO 590 +  
ATTO 590 meta-isomer(1+) +  
ATTO 590 para-isomer(1+) +  
avenic acid B 
azure B  
benazeprilat +   
benzenedicarboxylic acid +   
benzylpenicilloyl-cysteine 
betalamic acid 
bilirubin IIIalpha 
bilirubin IXalpha  
bilirubin XIIIalpha 
biliverdin beta 
biliverdin delta 
bromosuccinic acid 
C4-dicarboxylic acid +   
Calcium propionate 
candoxatrilat +   
cantharidic acid  
carbamazepine-10,11-epoxide  
carboxyibuprofen 
A dicarboxylic acid that is ibuprofen in which one of the methyl groups in the isobutyl portion has been converted to the corresponding carboxylic acid.
carboxyibuprofen(2-) 
Carboxyphosphonopyruvate 
ceanothic acid 
ceftaroline +  
ceftibuten +   
chenodeoxycholic acid 3-O-(beta-D-glucuronide) 
chlorendic acid  
cinaciguat  
cis-2-Carboxycyclohexyl-acetic acid 
citraconic acid  
clopidogrel carboxylic acid 
CNDAC +  
cotinine N-oxide 
cromoglycic acid 
cyclobutanedicarboxylic acid +  
cyclosporin A metabolite M1 +  
cyclosporin A metabolite M10 
cyclosporin A metabolite M13 
cyclosporin A metabolite M16 +  
cyclosporin A metabolite M17 +  
cyclosporin A metabolite M18 +  
cyclosporin A metabolite M1A 
cyclosporin A metabolite M1cAL 
cyclosporin A metabolite M21 +  
cyclosporin A metabolite M25 
cyclosporin A metabolite M26 
cyclosporin A metabolite M8 +  
cyclosporin A metabolite M9 
D617 
deoxylimonoic acid D-ring-lactone 
desmethyl loperamide 
desmethyldoxepin +  
desmethylnaproxen  
desmethylnaproxen sulfate 
desmethylnaproxen(1-) 
desmethylranitidine 
dexibuprofen 
dibenzo[b,d]furan-4,6-dicarboxylic acid 
diclofenac beta-D-glucosiduronic acid 
didesethylflurazepam 
dihydrodipicolinic acid +  
dihydrokainic acid 
dihydroxymalonic acid 
dimethylcarbate 
dimethylmaleic acid 
dimethylmalonic acid 
dioxoaminopyrine 
diphenic acid 
doxorubicinol 
enalaprilat (anhydrous) +   
enol-oxaloacetic acid 
eprosartan +  
ethisterone 
ethylmalonic acid +   
fenofibric acid 
Ferrous fumarate 
fertaric acid +  
furan-2,5-dicarboxylic acid 
gamma-CEHC beta-glucuronide 
gamma-Glu-Tyr 
gibberellin A110 
gibberellin A12 +  
gibberellin A14 +  
gibberellin A15 (diacid form) 
gibberellin A18 
gibberellin A19 
gibberellin A24 
gibberellin A36 
gibberellin A44 diacid 
gibberellin A51-catabolite 
gibberellin A53 +  
gibberellin A8-catabolite 
glycinexylidide +  
Glycinoeclepin A 
hematoporphyrin 
heme d cis-diol +  
heme d trans-diol 
heptenedioic acid +  
heptylmalonic acid 
hexenedioic acid +  
hydroxyalbendazole 
hydroxyfenbendazole 
hydroxymalonic acid 
hyocholic acid 6-O-(beta-D-glucuronide) 
hyodeoxycholic acid 6-O-(beta-D-glucuronide) 
ibuproxam 
imidaprilat  
indometacin +   
iron methylchlorin 
isoceanothic acid 
isoglutamic acid 
Isoniazid alpha-ketoglutaric acid 
isonocardicin A 
isonocardicin C 
itaconic acid +  
ixazomib +   
kainic acid +   
L-2-Aminoadipate adenylate 
lansic acid +  
Lauroyl peroxide 
levibuprofen 
limonoic acid 
lithocholic acid 3-O-(beta-D-glucuronide) 
lucensimycin E 
luteolin-7-O-[beta-D-glucuronosyl-(1->2)-beta-D-glucuronide] 
mesaconic acid +  
methotrexate  
mevinolinic acid 
mitchellene D 
mono(3-carboxypropyl) phthalate 
mono(6-carboxy-2-methylheptyl) phthalate 
mono(7-carboxy-2-methyloctyl) phthalate 
mono[2-(carboxymethyl)hexyl] phthalate 
monoethylglycinexylidide +   
mycobilin a 
mycobilin b 
N,N-didesmethylvenlafaxine 
N,O-didesmethylvenlafaxine 
N-(4-aminobenzoyl)-L-glutamic acid 
N-acetylsulfamethoxazole 
N-acyl-aspartic acid +   
N-amidinoaspartic acid +  
N-carboxy-beta-alanine 
N-desmethylvenlafaxine 
N-formimidoyl-L-glutamic acid 
N-formylisoglutamic acid 
N-malonyltryptophan 
naphthalene-2,6-dicarboxylic acid 
nedocromil  
nigranoic acid 
nitrazepam +   
nitrososulfadiazine 
nitrososulfapyridine 
nocardicin A 
nocardicin C 
Nonate 
norfentanyl 
nortriptyline  
norverapamil  
O-desethyl candesartan 
O-desmethylvenlafaxine 
octenedioic acid +  
olsalazine 
oxidopamine  
oxo dicarboxylic acid +   
oxyphenbutazone +   
p-coutaric acid +  
paliperidone 
pamoic acid  
paracetamol sulfate +   
penillic acid +  
pentenedioic acid +  
Perazine dimalonate 
perindoprilat 
phenazine-1,6-dicarboxylic acid 
polyunsaturated dicarboxylic acid +   
poricoic acid A 
poricoic acid C 
poricoic acid G 
poricoic acid H 
porphobilinogen  
prednisolone +   
procainamide 4-hydroxylamine 
proglumide +  
promazine sulfoxide 
psilocin +  
pyrandicarboxylic acid +  
pyrazine-2-carboxylic acid  
pyridine N-oxide +   
pyridinedicarboxylic acid +   
pyrimidinedicarboxylic acid +  
pyrroledicarboxylic acid +  
pyrrolidinedicarboxylic acid +  
quinaprilat  
quinolinedicarboxylic acid 
rac-nortilidine 
ramiprilat  
ranitidine N-oxide 
ranitidine-S-oxide 
ritalinic acid  
S-(5-acetamido-2-hydroxyphenyl)-N-acetyl-L-cysteinate 
S-(5-acetamido-2-hydroxyphenyl)-N-acetyl-L-cysteine 
salvianolic acid B  
shinorine 
sinapoyltartronic acid 
SN-38 +   
spiraprilat +   
SQ 26,992 
succimer  
sulfadiazine hydroxylamine 
sulfanegen 
sulfapyridine hydroxylamine 
tedizolid 
tenofovir (anhydrous) +   
tensyuic acid B +  
tensyuic acid C 
tensyuic acid E 
tensyuic acid F 
teriflunomide  
Tetrahydro-2,5-furan-diacetic acid 
theophylline  
thiazepinedicarboxylic acid +  
thiazolidinedicarboxylic acid +  
thiodiacetic acid 
thiodiacetic acid sulfoxide 
thiomorpholine-3,5-dicarboxylic acid +  
trandolaprilat 
traumatic acid +  
uridine +   
WR-1065  
zofenoprilat 

Synonyms
Exact Synonyms: 3-[4-(1-carboxyethyl)phenyl]-2-methylpropanoic acid
Related Synonyms: 2,4'-(2-Carboxypropyl)phenylpropionic acid ;   2-(4-(2-Carboxypropyl)phenyl)propionic acid ;   Carboxy-ibuprofen ;   Formula=C13H16O4 ;   Ibuprofen COOH ;   InChI=1S/C13H16O4/c1-8(12(14)15)7-10-3-5-11(6-4-10)9(2)13(16)17/h3-6,8-9H,7H2,1-2H3,(H,14,15)(H,16,17) ;   InChIKey=DIVLBIVDYADZPL-UHFFFAOYSA-N ;   SMILES=C=1C=C(C=CC1C(C(=O)O)C)CC(C(=O)O)C
Xrefs: CAS:15935-54-3 "ChemIDplus" ;   HMDB:HMDB0060564 ;   PMID:21079932 "Europe PMC" ;   PMID:9094205 "Europe PMC" ;   Reaxys:5951324 "Reaxys"
Cyclic Relationships: is_conjugate_acid_of CHEBI:133198 ;   is_conjugate_acid_of CHEBI:133200

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.