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Term:
all-trans-4,16-dihydroxyretinoic acid (CHEBI:139259)
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Parent Terms Term With Siblings Child Terms
(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol 
(+)-isoepoxydon 
(13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid 
(18R)-resolvin E3 
(18S)-resolvin E1 
(18S)-resolvin E2 
(2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal 
(2R,3R)-2,3-dihydroxy-3-methylpentanoic acid 
(2Z)-2,3-dihydroxyacrylic acid 
(3R)-3,10-dihydroxydecanoic acid +  
(3R)-3,11-dihydroxyundecanoic acid +  
(3R)-3,12-dihydroxylauric acid +  
(3R)-3,13-dihydroxytridecanoic acid +  
(3R)-3,14-dihydroxymyristic acid +  
(3R)-3,15-dihydroxypentadecanoic acid +  
(3R)-3,17-dihydroxymargaric acid +  
(3R)-3,18-dihydroxyoctadecanoic acid +  
(3R)-3,19-dihydroxynonadecanoic acid +  
(3R)-3,20-dihydroxyicosanoic acid +  
(3R)-3,21-dihydroxyhenicosanoic acid +  
(3R)-3,22-dihydroxybehenic acid +  
(3R)-3,22-dihydroxytricosanoic acid +  
(3R)-3,9-dihydroxynonanoic acid +  
(3R)-all-trans-3-hydroxyretinal 
(3R,10R)-3,10-dihydroxyundecanoic acid +  
(3R,11R)-3,11-dihydroxylauric acid +  
(3R,12R)-3,12-dihydroxytridecanoic acid +  
(3R,13R)-3,13-dihydroxymyristic acid +  
(3R,14R)-3,14-dihydroxypentadecanoic acid +  
(3R,15R)-3,15-dihydroxypalmitic acid +  
(3R,16R)-3,16-dihydroxymargaric acid +  
(3R,18R)-3,18-dihydroxynonadecanoic acid +  
(3R,19R)-19-dihydroxyicosanoic acid +  
(3R,20R)-3,20-dihydroxyhenicosanoic acid +  
(3R,21R)-3,21-dihydroxybehenic acid +  
(3R,22R)-3,22-dihydroxytricosanoic acid +  
(3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid +   
(3R,6E,8S,10E)-3,8-dihydroxyhexadeca-6,10-dienoic acid 
(3R,8R)-3,8-dihydroxynonanoic acid +  
(3R,9R)-3,9-dihydroxydecanoic acid +  
(3S)-11-cis-3-hydroxyretinal 
(3S)-all-trans-3-hydroxyretinal 
(4S)-2,3-dehydroleucocyanidin 
(4S)-2,3-dehydroleucopelargonidin 
(4S)-4,16-dihydroxyretinoic acid 
(4S,5S)-4,5-dihydroxy-2,6-dioxohexanoic acid 
(4Z,7Z,10S,11E,13Z,15E,17S,19Z)-10,17-dihydroxydocosahexaenoic acid 
(4Z,7Z,10Z,12E,14R,16Z,19Z)-14,22-dihydroxydocosahexaenoic acid 
(4Z,7Z,10Z,12E,14R,16Z,19Z,21R)-dihydroxydocosahexaenoic acid 
(4Z,7Z,10Z,12E,14R,16Z,19Z,21S)-dihydroxydocosahexaenoic acid 
(4Z,7Z,10Z,12E,14S,16Z)-14-hydroxydocosapentaenoic acid 
(4Z,7Z,10Z,12E,14S,16Z,19Z)-14,22-dihydroxydocosahexaenoic acid 
(4Z,7Z,10Z,12E,14S,16Z,19Z,21S)-dihydroxydocosahexaenoic acid 
(4Z,7Z,10Z,13Z,15E,17S)-17-hydroxydocosapentaenoic acid 
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid +   
(4Z,7Z,10Z,14E,16Z,19Z)-13-hydroxydocosahexaenoic acid 
(5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-icosatetraenoic acid 
(5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-icosatetraenoic acid 
(5Z,11Z,14Z)-8,9-dihydroxyicosatrienoic acid +  
(5Z,8Z,11Z)-14,15-dihydroxyicosatrienoic acid +  
(6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid +   
(6E,8Z,11Z,13E,15S)-15-hydroxy-5-oxoicosatetraenoic acid 
(7R,14S)-dihydroxy-(4Z,8E,10E,12Z,16Z,19Z)-docosahexaenoic acid 
(7R,14S)-dihydroxy-(8E,10E,12Z,16Z,19Z)-docosapentaenoic acid 
(7S,14S)-dihydroxy-(4Z,8E,10E,12Z,16Z,19Z)-docosahexaenoic acid 
(7S,14S)-dihydroxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoic acid 
(8S)-cystein-S-yl-(7R,17S)-dihydroxy-(4Z,9,11,13Z,15E,19Z)-docosahexaenoic acid 
(8S)-glutathionyl-(7R,17S)-dihydroxy-(4Z,9,11,13Z,15E,19Z)-docosahexaenoic acid 
(8S)-glycinylcystein-S-yl-(7R,17S)-dihydroxy-(4Z,9,11,13Z,15E,19Z)-docosahexaenoic acid 
(9R,10S)-dihydroxyoctadecanoic acid 
(9S,10R)-dihydroxyoctadecanoic acid 
(9Z,12Z)-11-hydroxyoctadecadienoic acid 
(E)-4-hydroxynon-2-en-1-ol 
(E)-dec-3-en-2-ol 
(R)-2,4-dihydroxy-3-oxobutanoic acid 
(R)-3,4-dihydroxy-2-oxobutanoic acid 
(R,R)-3,17-dihydroxyoctadecanoic acid +  
(S)-2,4-dihydroxy-3-oxobutanoic acid 
(S)-3,4-dihydroxy-2-oxobutanoic acid 
(Z)-6-amino-2-hydroxy-4-(2-oxovinyl)hept-3-enedioic acid 
(Z,S)-cinerolone 
(Z,S)-jasmolone 
1,4-dihydroxy-2-naphthoic acid +   
1-O-(5,6-epoxyretinoyl)-beta-D-glucuronic acid 
1-O-all-trans-retinoyl-beta-glucuronic acid 
1-oxo-3beta,23-dihydroxyolean-12-en-28-oic acid 
10,11-dihydroleukotriene B4 
10-HETE 
11 hydroxy-(14R,15S)-epoxy-(5Z,8Z,12E)-icosatrienoic acid 
11,12,15-trihydroxy-(5Z,8Z,13E)-icosatrienoic acid 
11,14,15-trihydroxy-(5Z,8Z,12E)-icosatrienoic acid 
11-cis-3-Hydroxyretinal 
12,20-dioxoleukotriene B4 
12-epi-leukotriene B4 
13,14(S)-dihydroxy-(7Z,9E,11E,16Z,19Z)-docosapentaenoic acid 
13,14,15-trihydroxy-(5Z,8Z,11Z)-icosatrienoic acid 
13-HETE +  
13-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-icosatrienoic acid +  
14(S),21-dihydroxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoic acid 
14-HDoHE +  
16,16-dimethylprostaglandin E2  
16-HETE +  
16-oxoresolvin D2 
17-oxoresolvin D1 
18-hydroxycarbocyclic thromboxane A2 
18-hydroxyleukotriene B4 
18-hydroxythromboxane A2 
19-hydroxycarbocyclic thromboxane A2 
19-hydroxyleukotriene B4 
19-hydroxyprostaglandin I2 
19-hydroxythromboxane A2 
2,3-dihydroxy-2-methylpropanoic acid 
2,3-dihydroxy-3-methylbutanoic acid +  
2,3-dihydroxydodecanoic acid 
2,4-dihydroxy-5-methyl-6-oxo-2,4-hexadienoic acid 
2-[(9S,11R)-epidioxy-(15S)-hydroxy-(5Z,13E)-prostadienoyl]-sn-glycero-3- phosphocholine 
2-[(9S,11R)-epidioxy-(15S)-hydroxy-(5Z,13E)-prostadienoyl]-sn-glycero-3-phosphoethanolamine 
2-hydroxy-3-butenyldesulfoglucosinolate 
2-trans-4'-dihydroabscisic acid 
20-hydroxyprostaglandin A1 
20-hydroxyprostaglandin E1 
20-hydroxyprostaglandin E2 
20-oxoleukotriene B4 
23-hydroxyursolic acid +  
2alpha,3beta-dihydroxy-20(29)-lupen-28-oic acid 
2alpha,3beta-dihydroxyolean-13(18)-en-28-oic acid 
3,12-dihydroxylauric acid 
3,16-dihydroxyhexadecanoic acid +  
3,18-dihydroxyoctadecanoic acid 
3,4-dihydroxy-4-methylhexadecanoic acid +  
3-(3-hydroxyphenyl)-3-hydroxypropanoic acid 
3-deoxycapsidiol 
3alpha,7alpha-dihydroxy-5beta-cholestan-26-oic acid +  
3alpha,7beta-dihydroxy-5beta-cholest-24-en-26-oic acid 
3beta-hydroxy-15,16-epoxydolabrene 
3beta-hydroxycostunolide 
4-epihederagenin 
4-hydroxyphenyl retinamide  
5(S),8(R)-DiHODE 
5,20-diHEPE 
5,6-epoxyretinoic acid +  
6-isopropenyl-4,4a-dimethyl-2,3,4,4a,5,6,7,8-octahydronaphthalen-2-ol +  
6-trans-leukotriene B4 +  
7(S),8(S)-DiHODE 
7-HETE 
7-oxoresolvin D2 
9,10-dihydroxyoctadecanoic acid +  
9-(3-hydroxy-2,6,6-trimethyl-1-cyclohexenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid 
9-cis-4-hydroxyretinoic acid 
9-cis-4-oxoretinoic acid 
acetic acid [3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenyl] ester 
acitretin +   
all-trans-16-hydroxyretinoic acid 
all-trans-18-hydroxyretinoic acid 
all-trans-3,4-didehydro-13,14-dihydroretinol 
all-trans-3,4-didehydroretinoic acid 
all-trans-3,4-didehydroretinol +  
all-trans-3-Hydroxyretinal 
all-trans-4,16-dihydroxyretinoic acid 
A retinoid that consists of all-trans-retinoic acid bearing two hydroxy substituents at positions 4 and 16.
all-trans-4,18-dihydroxyretinoic acid 
all-trans-4-hydroxyretinal 
all-trans-4-hydroxyretinoic acid +   
all-trans-4-hydroxyretinol 
all-trans-4-oxo-16-hydroxyretinoic acid 
all-trans-4-oxo-18-hydroxyretinoic acid 
all-trans-4-oxoretinal  
all-trans-4-oxoretinoic acid +   
all-trans-4-oxoretinol  
all-trans-7,8-dihydroretinol 
all-trans-acitretin  
all-trans-retinol-R 
alpha-(hydroxymethyl)serine 
arotinoid acid  
aspirin-triggered protectin D1 
aspirin-triggered resolvin D1 
aspirin-triggered resolvin D2 
aspirin-triggered resolvin D3 
aspirin-triggered resolvin D4 
aspirin-triggered resolvin D5 
aspirin-triggered resolvin D6 
atorvastatin 
auxin a 
Avermectin B2a aglycone 
bexarotene  
carbocyclic thromboxane A2 +   
cerivastatin  
Delta(6)-trans,Delta(8)-cis-leukotriene B4 
Delta(6)-trans-12-epi-leukotriene B4 
DHET +  
DiHDPE +  
DiHOME +  
dihydro-N-retinylidene-N-retinylphosphatidylethanolamine 
dihydromonacolin L acid +  
dihydropyriculariol 
dihydropyriculol 
dihydroxydocosahexaenoic acid +  
dihydroxyicosatetraenoic acid +  
dihydroxyphenylacetic acid +   
epi-maslinic acid 
etretinate 
gibberellin A98 
hederagenin +   
hydroxyretinoic glucuronide +  
ketoretinoic acid glucuronide +  
leukotriene B4 +   
leukotriene B5  
marinolic acid C 
maslinic acid +   
mevalonic acid +   
mevinolinic acid 
monacolin L acid 
motretinide 
N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenamide 
N-retinylidene-N-retinylethanolamine 
N-retinylidene-N-retinylphosphatidylethanolamine 
N-retinylidenephosphatidylethanolamine 
pantoic acid +  
piericidin A  
pitavastatin  
prostaglandin A3 
prostaglandin D2 1-glyceryl ester 
prostaglandin D2 2-glyceryl ester 
prostaglandin E2 1-glyceryl ester 
prostaglandin E2 2-glyceryl ester 
prostaglandin F1alpha alcohol 
prostaglandin F2alpha 2-glyceryl ester 
prostaglandin I2 2-glyceryl ester 
prostaglandin J3 +  
protectin D1 +  
pyriculariol 
pyriculol +  
resolvin D2  
resolvin D3 
resolvin D4 
resolvin D5 
resolvin D6 
resolvin E2 
resolvin E3 
retinals +   
retinoic acid +   
retinol +   
Retinyl beta-glucuronide 
retinyl ester +   
rosuvastatin  
tamibarotene  
tazarotene  
tazarotenic acid +   
TX-1875 
vitamin A +  

Synonyms
Exact Synonyms: (2E,4E,6E,8E)-9-[3-hydroxy-6-(hydroxymethyl)-2,6-dimethylcyclohex-1-en-1-yl]-3,7-dimethylnona-2,4,6,8-tetraenoic acid
Related Synonyms: 4,16-dihydroxy-all-trans-retinoic acid ;   4,16-dihydroxyretinoic acid ;   Formula=C20H28O4 ;   InChI=1S/C20H28O4/c1-14(6-5-7-15(2)12-19(23)24)8-9-17-16(3)18(22)10-11-20(17,4)13-21/h5-9,12,18,21-22H,10-11,13H2,1-4H3,(H,23,24)/b7-5+,9-8+,14-6+,15-12+ ;   InChIKey=DGCPGJKPROZYMN-ZMNXUKPGSA-N ;   SMILES=C1(C)(CO)CCC(C(=C1\\C=C\\C(=C\\C=C\\C(=C\\C(=O)O)\\C)\\C)C)O
Xrefs: PMID:22020119 "SUBMITTER"
Cyclic Relationships: is_conjugate_acid_of CHEBI:139260

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.