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Term:
cyclosporin A metabolite M18 (CHEBI:140175)
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Parent Terms Term With Siblings Child Terms
(+)-(7R,7'R,8S,8'S)-4'-hydroxy-3,3',4,5,5'-pentamethoxy-7,7'-epoxylignan-9,9'-diol 
(+)-(7S,8R,8'R)-5,5'-dimethoxylariciresinol 
(+)-3'-hydroxylarreatricin 
(+)-5'-methoxylariciresinol 
(+)-lariciresinol +   
(+)-larreatricin 
(+)-tephrorin A 
(+)-tephrorin B 
(-)-lariciresinol  
(-)-larreatricin 
(13R)-13-dihydrocarminomycin 
(1R,2S)-nortilidine +  
(1S,2R)-nortilidine +  
(1S,3R)-dihydroxy-(20S)-[(5'R)-(2"-hydroxy-2"-propyl)-(2'S)-tetrahydrofuryl]-22,23,24,25,26,27-hexanor-1alpha-hydroxyvitamin D3 
(1S,3R)-dihydroxy-(20S)-[(5'S)-(2"-hydroxy-2"-propyl)-(2'R)-tetrahydrofuryl]-22,23,24,25,26,27-hexanor-1alpha-hydroxyvitamin D3 
(1S,3R)-dihydroxy-(20S)-[(5'S)-(2"-hydroxy-2"-propyl)-(2'S)-tetrahydrofuryl]-22,23,24,25,26,27-hexanor-1alpha-hydroxyvitamin D3 
(2R,5S)-linalyl oxide 
(2S)-2-(4-\{[(1R,2S)-2-hydroxycyclopentyl]methyl\}phenyl)propanoic acid 
(5-hydroxyindol-3-yl)acetic acid  
(6-methoxy-2-naphthyl)acetic acid 
(7R)-7-hydroxylariciresinol 
(7R)-7-hydroxytaxiresinol 
(±)-cis-Linalyl oxide 
1',4-dihydroxymidazolam 
1,1,1,3,3,3-hexafluoropropan-2-ol  
1-(3-chlorophenyl)piperazine  
1-[1-(1-adamantyl)butyl]-3-(2-oxolanylmethyl)thiourea 
1-hydroxymidazolam +  
1-hydroxymidazolam beta-D-glucuronide 
10,11-trans-dihydroxy-10,11-dihydrocarbamazepine +  
12-Epoxyobtusallene IV 
12-hydroxynevirapine 
2,3,4-trihydroxytetrahydrofuran +  
2,6-dimethylaniline +   
2-(3,5-dioxo-4-phenyl-2-oxolanylidene)-2-phenylacetic acid methyl ester 
2-(dichloromethyl)tetrahydrofuran 
2-[5-(2-hydroxypropyl)oxolan-2-yl]propanoic acid 
2-\{2-chloro-4-(methylsulfonyl)-3-[(tetrahydrofuran-2-ylmethoxy)methyl]benzoyl\}cyclohexane-1,3-dione +  
2-formylbenzoic acid 
2-hydroxyibuprofen 
2-methoxyacetaminophen glucuronide 
2-methoxyacetaminophen glucuronide(1-) 
2-methoxyacetaminophen sulfate 
2-methoxyacetaminophen sulfate(1-) 
3'-hydroxy-4'-methoxydiclofenac 
3'-hydroxydiclofenac 
3,4-dihydroxymandelic acid  
3,5-dihydroxyphenylacetic acid 
3-[5-[2-[4-(2-carboxyethenyl)-3-oxo-5-propyl-2-furanyl]propan-2-yl]-4-oxo-2-propyl-3-furanyl]-2-propenoic acid 
3-chlorobenzoic acid 
3-hydroxy-2,2-dimethylbutyric acid 
3-hydroxymethylantipyrine 
3-Ketoapotrichothecene 
4',5-dihydroxydiclofenac 
4'-hydroxydiclofenac  
4-(acetylamino)-3-hydroxyphenyl hydrogen sulfate 
4-(acetylamino)-3-hydroxyphenyl sulfate 
4-(methylamino)antipyrine 
4-(trifluoromethyl)phenol 
4-acetamidoantipyrine 
4-aminoantipyrine 
4-ethoxyaniline +   
4-formylaminoantipyrine 
4-hydroxy-2,6-dimethylaniline 
4-hydroxy-6-methylaniline 
4-hydroxymidazolam +  
4-hydroxymidazolam beta-D-glucuronide 
4-hydroxypropofol 
5'-hydroxyomeprazole  
5-carboxy-2'-deoxyuridine 
5-fluorouridine 5'-monophosphate 
5-hydroxydiclofenac  
5-hydroxydiclofenac quinone imine 
5-O-desmethyldonepezil 
6-(tetrahydrofuran-2-ylmethoxy)-9H-purin-2-amine 
6-azauridine +   
7-hydroxyticlopidine 
9-(tetrahydrofuryl)adenine  
acetaminophen O-beta-D-glucosiduronic acid  
acetohydrazide +   
ACT-132577 +   
ACT-333679 +  
adefovir +   
alborixin  
alkyltetrahydrofuran +  
alloxanthine +   
AMCR277A 
AMCR277B 
aripiprazole  
aryltetrahydrofuran +  
astragaloside I 
astragaloside II 
atenolol acid 
atenolol-desisopropyl 
aureothin 
azure B  
Bisabolol oxide B 
bromuconazole  
cabraleadiol 
cabraleadiol monoacetate 
cabraleone 
carbamazepine-10,11-epoxide  
carboxyibuprofen 
carboxyibuprofen(2-) 
ceftaroline +  
Chalcogran 
clopidogrel carboxylic acid 
CNDAC +  
cornusalterin L 
cotinine N-oxide 
cycloastragenol +   
cyclosporin A metabolite M1 +  
cyclosporin A metabolite M10 
cyclosporin A metabolite M13 
cyclosporin A metabolite M16 +  
cyclosporin A metabolite M17 +  
cyclosporin A metabolite M18 +  
A cyclosporin A derivative that is cyclosporin A metabolite M17 in which the hydroxy group at position 3 of residue 1 [(2S,3R,4R,6E)-3,8-dihydroxy-4-methyl-2-(methylamino)oct-6-enamide] has undergone addition to the double bond at position 6 to afford the corresponding dioxolane ring.
cyclosporin A metabolite M1A 
cyclosporin A metabolite M1cAL 
cyclosporin A metabolite M21 +  
cyclosporin A metabolite M25 
cyclosporin A metabolite M26 
cyclosporin A metabolite M8 +  
cyclosporin A metabolite M9 
D617 
Dehydrongaione 
deoxyflindissone 
desmethyl loperamide 
desmethyldoxepin +  
desmethylnaproxen  
desmethylnaproxen sulfate 
desmethylnaproxen(1-) 
desmethylranitidine 
diclofenac beta-D-glucosiduronic acid 
didesethylflurazepam 
dinotefuran +   
dioxoaminopyrine 
doxorubicinol 
Esulatin H, (rel)- 
ethisterone 
Euphorbiaproliferin C 
Euphorbiaproliferin G 
faropenem +  
faropenem(1-) +  
fenofibric acid 
futokadsurin A 
futokadsurin B 
futokadsurin C 
gigantetronenin 
gigantrionenin 
glycinexylidide +  
hydroxyalbendazole 
hydroxyfenbendazole 
imidaprilat  
indometacin +   
Ipomoeamarone 
Isobenzan 
ixazomib +   
Jatrophone 
linalool 3,6-oxide primeveroside 
Linalyl oxide 
manassantin A 
manassantin B 
meso-3,3'-didemethoxynectandrin B 
mevinolinic acid 
monoethylglycinexylidide +   
mutalomycin 
N,N-didesmethylvenlafaxine 
N,O-didesmethylvenlafaxine 
N-acetylsulfamethoxazole 
N-desmethylvenlafaxine 
nitrazepam +   
nitrososulfadiazine 
nitrososulfapyridine 
norfentanyl 
nortriptyline  
norverapamil  
nucleoside +   
O-desethyl candesartan 
O-desmethylvenlafaxine 
Obtusallene X, (rel)- 
ocotillone 
oxidopamine  
oxolane +   
oxyphenbutazone +   
paliperidone 
paracetamol sulfate +   
perindoprilat 
posaconazole  
prednisolone +   
procainamide 4-hydroxylamine 
proglumide +  
promazine sulfoxide 
psilocin +  
pyrazine-2-carboxylic acid  
pyridine N-oxide +   
rac-nortilidine 
ramiprilat  
ranitidine N-oxide 
ranitidine-S-oxide 
rel-(-)-(7S,7'R,8S,8'R)-4,4'-dihydroxy-3,3',5'-trimethoxy-7,7'-epoxylignan 
ritalinic acid  
S-(5-acetamido-2-hydroxyphenyl)-N-acetyl-L-cysteinate 
S-(5-acetamido-2-hydroxyphenyl)-N-acetyl-L-cysteine 
sapinmusaponin Q 
sapinmusaponin R 
SN-38 +   
spectinabilin 
spiraprilat +   
sulfadiazine hydroxylamine 
sulfapyridine hydroxylamine 
taxiresinol 
tedizolid 
tenofovir (anhydrous) +   
teriflunomide  
tetrahydrofurancarboxylic acid +  
tetrahydrofuranol +   
tetrahydrofuranone +   
tetrahydrofurfuryl alcohol +  
tetrahydrofuryl ester +   
tetrahydrofuryl ether +  
tetrahydrofurylmethyl ester +  
theophylline +   
trandolaprilat 
trans-furan linalool oxide 
uridine +   
Vitex norditerpenoid 1 
Vitex norditerpenoid 2 
vladinol D 
WR-1065  
zofenoprilat 

Synonyms
Exact Synonyms: (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(2R,3R)-5-(2-hydroxyethyl)-3-methyltetrahydrofuran-2-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
Related Synonyms: AM1c ;   Formula=C62H111N11O13 ;   InChI=1S/C62H111N11O13/c1-24-43-58(81)67(17)32-48(75)68(18)44(27-33(2)3)55(78)66-49(37(10)11)61(84)69(19)45(28-34(4)5)54(77)63-40(15)53(76)64-41(16)57(80)70(20)46(29-35(6)7)59(82)71(21)47(30-36(8)9)60(83)72(22)50(38(12)13)62(85)73(23)51(56(79)65-43)52-39(14)31-42(86-52)25-26-74/h33-47,49-52,74H,24-32H2,1-23H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/t39-,40+,41-,42?,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1 ;   InChIKey=OPQZHVFVHOLQNE-JFGKHBSWSA-N ;   M18 ;   SMILES=[C@H]1(N(C([C@@H](N(C([C@@H](N(C)C([C@@H](N(C([C@H](NC([C@@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C)C(CN(C([C@@H](NC1=O)CC)=O)C)=O)CC(C)C)=O)C(C)C)=O)C)CC(C)C)=O)C)=O)C)=O)C)CC(C)C)=O)CC(C)C)=O)C)C(C)C)=O)C)[C@]2([C@H](C)CC(O2)(CCO)[H])[H] ;   cyclosporin A metabolite AM1c ;   cyclosporin metabolite AM1c ;   cyclosporin metabolite M18 ;   cyclosporine A metabolite AM1c ;   cyclosporine A metabolite M18 ;   cyclosporine metabolite AM1c ;   cyclosporine metabolite M18
Xrefs: PMID:1362930 "Europe PMC" ;   PMID:17301005 "Europe PMC" ;   PMID:1834063 "Europe PMC" ;   PMID:1895678 "Europe PMC" ;   PMID:1943052 "Europe PMC" ;   PMID:1971578 "Europe PMC" ;   PMID:2060135 "Europe PMC" ;   PMID:22210099 "Europe PMC" ;   PMID:2297901 "Europe PMC" ;   PMID:2950629 "Europe PMC" ;   PMID:2966788 "Europe PMC" ;   PMID:3311467 "Europe PMC" ;   PMID:3538573 "Europe PMC" ;   PMID:7624874 "Europe PMC" ;   PMID:8400080 "Europe PMC" ;   PMID:8894806 "Europe PMC" ;   PMID:8971957 "Europe PMC"

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.