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Term:
cyclosporin A metabolite M1A (CHEBI:140178)
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Parent Terms Term With Siblings Child Terms
(+)-DCA-CL 
(-)-DCA-CL 
(13R)-13-dihydrocarminomycin 
(1R,2S)-nortilidine +  
(1S,2R)-nortilidine +  
(2-trans,6-cis)-dodeca-2,6-dienoic acid +  
(2E)-11-hydroxy-2-dodecenoic acid 
(2E)-11-hydroxyundec-2-enoic acid +  
(2E)-12-hydroxydodec-2-enoic acid +  
(2E)-13-hydroxytridec-2-enoic acid +  
(2E)-14-hydroxytetradec-2-enoic acid +  
(2E)-15-hydroxypentadec-2-enoic acid +  
(2E)-16-hydroxyhexadec-2-enoic acid +  
(2E)-17-hydroxyheptadec-2-enoic acid +  
(2E)-18-hydroxyoctadec-2-enoic acid +  
(2E)-19-hydroxynonadec-2-enoic acid +  
(2E)-2-heptadecenoic acid +  
(2E)-20-hydroxyicos-2-enoic acid +  
(2E)-21-hydroxyhenicos-2-enoic acid +  
(2E)-3-methylhex-2-enoic acid 
(2E)-7-hydroxyhept-2-enoic acid +  
(2E)-9-hydroxynon-2-enoic acid +  
(2E,10R)-10-hydroxyundec-2-enoic acid +  
(2E,11R)-11-hydroxydodec-2-enoic acid +  
(2E,12R)-12-hydroxytridec-2-enoic acid +  
(2E,13R)-13-hydroxytetradec-2-enoic acid +  
(2E,14R)-14-hydroxypentadec-2-enoic acid +  
(2E,15R)-15-hydroxyhexadec-2-enoic acid +  
(2E,16R)-16-hydroxyheptadec-2-enoic acid +  
(2E,17R)-17-hydroxyoctadec-2-enoic acid +  
(2E,18R)-18-hydroxynonadec-2-enoic acid +  
(2E,19R)-19-hydroxyicos-2-enoic acid +  
(2E,20R)-20-hydroxyhenicos-2-enoic acid +  
(2E,24R)-24-[(alpha-L-ascarosyl)oxy]-2-methylpentacos-2-enoic acid 
(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoic acid 
(2E,4E)-hexa-2,4-dienoic acid +   
(2E,4E,6R,8Z)-6-hydroxytetradeca-2,4,8-trienoic acid 
(2E,4Z)-2-hydroxy-7-methyl-6-oxo-2,4-octadienoic acid 
(2E,4Z)-6-(4-chlorophenyl)-2-hydroxy-6-oxohexa-2,4-dienoic acid 
(2E,4Z)-8-hydroxydeca-2,4-dienoic acid +  
(2E,6E,10E)-geranylgeranic acid +  
(2E,6E,10E,14E)-omega-hydroxygeranylgeranic acid 
(2E,6E,10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoic acid 
(2E,6R)-6-hydroxyhept-2-enoic acid +  
(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoic acid +  
(2E,7R)-7-hydroxyoct-2-enoic acid +  
(2E,8R)-8-hydroxynon-2-enoic acid +  
(2E,9R)-9-hydroxydec-2-enoic acid +  
(2S)-2-(4-\{[(1R,2S)-2-hydroxycyclopentyl]methyl\}phenyl)propanoic acid 
(2S,3R)-glycosmisic acid 
(2Z)-2,3-dihydroxyacrylic acid 
(2Z,4E)-4-hydroxymuconic semialdehyde 
(2Z,4Z)-2-hydroxyhexa-2,4-dienoic acid 
(3R)-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylic acid 
(3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carboxylic acid 
(5-hydroxyindol-3-yl)acetic acid  
(6-methoxy-2-naphthyl)acetic acid 
(E)-10-hydroxydec-2-enoic acid +   
(E)-11-methyldodec-2-enoic acid 
(E)-2,4,6-trimethyltetracos-2-enoic acid 
(E)-3-(indol-2-yl)acrylic acid 
(E)-3-(indol-3-yl)acrylic acid 
(E)-endo-beta-bergamoten-12-oic acid 
(E)-hexadec-2-enoic acid +  
(E)-non-2-enoic acid 
(E,E)-piperic acid +   
(Z)-13-methyltetradec-2-enoic acid 
(Z)-14-methylpentadec-2-enoic acid 
(Z)-3-amino-2-methylacrylic acid +  
(Z)-3-aminoacrylic acid 
(Z)-tetradec-2-enoic acid 
1',4-dihydroxymidazolam 
1'-deoxyabscisic acid 
1,1,1,3,3,3-hexafluoropropan-2-ol  
1,4,5,6-tetrahydro-6-oxonicotinic acid 
1-(3-chlorophenyl)piperazine  
1-carbapenem-3-carboxylic acid 
1-deoxy-11-oxopentalenic acid 
1-deoxypentalenic acid 
1-hydroxymidazolam +   
1-hydroxymidazolam beta-D-glucuronide  
10,11-trans-dihydroxy-10,11-dihydrocarbamazepine +  
12-hydroxynevirapine 
14-hydroxy-6,12-muuroloadien-15-oic acid 
2,3-dihydroxy-2,3-dihydrobenzoic acid +  
2,4-dihydroxy-5-methyl-6-oxo-2,4-hexadienoic acid 
2,6-dimethyl-5-methylenehept-2-enoic acid +  
2,6-dimethylaniline +   
2-acetamido-2-deoxy-3-O-(4-deoxy-alpha-L-threo-hex-4-enopyranosyluronic acid)-6-O-sulfo-D-galactopyranose +  
2-amino-5-chloro-cis,cis-muconic 6-semialdehyde 
2-aminoacrylic acid +  
2-aminomuconic 6-semialdehyde 
2-butenoic acid +   
2-chloroacrylic acid 
2-decenoic acid +  
2-dodecenoic acid +  
2-ethylacrylic acid 
2-formylbenzoic acid 
2-heptenoic acid +  
2-hexacosenoic acid +  
2-hydroxy-3-methyl-2-butenoic acid 
2-hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene) but-2-enoic acid 
2-hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene) but-2-enoic acid 
2-hydroxy-5-methyl-cis,cis-muconic semialdehyde 
2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoic acid 
2-hydroxy-6-oxo-2,4-heptadienoic acid +  
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid 
2-hydroxy-6-oxohexa-2,4-dienoic acid +  
2-hydroxyacrylic acid 
2-hydroxyibuprofen 
2-hydroxypenta-2,4-dienoic acid +  
2-methoxyacetaminophen glucuronide 
2-methoxyacetaminophen glucuronide(1-) 
2-methoxyacetaminophen sulfate 
2-methoxyacetaminophen sulfate(1-) 
2-methylbut-2-enoic acid +  
2-tetradecenoic acid +  
2-trans-4'-dihydroabscisic acid 
2-undecenoic acid +  
3'-hydroxy-4'-methoxydiclofenac 
3'-hydroxydiclofenac 
3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid 
3,4-dihydroxymandelic acid  
3,5-dihydroxyphenylacetic acid 
3,7-dimethylocta-2,6-dienoate(1-) 
3-(4,6-dihydroxy-3-oxocyclohexa-1,4-dien-1-yl)acrylic acid 
3-chlorobenzoic acid 
3-dehydroshikimic acid 
3-hydroxy-2,2-dimethylbutyric acid 
3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oic acid +  
3-hydroxybut-2-enoic acid +   
3-hydroxymethylantipyrine 
3-methylbut-2-enoic acid +  
3-nitroacrylic acid 
3alpha,7beta-dihydroxy-5beta-cholest-24-en-26-oic acid 
4',5-dihydroxydiclofenac 
4'-hydroxydiclofenac  
4,4'-diapolycopen-4-oic acid 
4,4'-diaponeurosporenoic acid 
4-(acetylamino)-3-hydroxyphenyl hydrogen sulfate 
4-(acetylamino)-3-hydroxyphenyl sulfate 
4-(methylamino)antipyrine 
4-(trifluoromethyl)phenol 
4-acetamidoantipyrine 
4-aminoantipyrine 
4-coumaroylshikimic acid 
4-deoxy-Delta(4)-beta-D-GlcpA 
4-ethoxyaniline +   
4-formylaminoantipyrine 
4-hydroxy-2,6-dimethylaniline 
4-hydroxy-6-methylaniline 
4-hydroxymidazolam +   
4-hydroxymidazolam beta-D-glucuronide 
4-hydroxypropofol 
5'-hydroxyomeprazole  
5-[(E)-caffeoyl]shikimic acid 
5-aminocyclohexa-1,3-diene-1-carboxylic acid +  
5-carboxy-2'-deoxyuridine 
5-fluorouridine 5'-monophosphate 
5-hydroxydiclofenac  
5-hydroxydiclofenac quinone imine 
5-O-desmethyldonepezil 
6-azauridine +   
6-imino-5-oxocyclohexa-1,3-dienecarboxylic acid 
6:2 fluorotelomer unsaturated carboxylic acid 
6beta,16beta-diacetoxy-25-hydroxy-3,7-dioxy-29-nordammara-1,17(20)-dien-21-oic acid 
7-deoxyloganetic acid +  
7-deoxyloganic acid 
7-hydroxyticlopidine 
7beta-aminocephalosporanic acid  
8,8a-epoxymorellic acid 
8:2 fluorotelomer unsaturated carboxylic acid 
8alpha,19-dihydroxylabd-13E-ene-15-oic acid 
abscisic acids +   
acetaminophen O-beta-D-glucosiduronic acid  
acetohydrazide +   
acrivastine  
acrylic acid +   
ACT-132577 +   
ACT-333679 +  
adefovir +   
all-trans-7-hydroxyhexadeca-2,4,8,10-tetraenoic acid +  
all-trans-acitretin  
alloxanthine +   
alpha-bergamotenoic acid 
alpha-santalenoic acid 
aripiprazole  
ascr#13 
ascr#15 +  
ascr#17 +  
ascr#19 +  
ascr#21 +  
ascr#23 
ascr#25 
ascr#29 
ascr#3 +  
ascr#31 
ascr#33 
ascr#35 
ascr#37 
ascr#7 +  
atenolol acid 
atenolol-desisopropyl 
azure B  
beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-D-GlcpNAc +  
caffeic acid quinone 
carbamazepine-10,11-epoxide  
carbapenem MM22383 
carboxyibuprofen 
carboxyibuprofen(2-) 
ceftaroline +  
cinnamic acids +   
cis-5,6-dihydroxy-4-isopropylcyclohexa-1,3-dienecarboxylic acid 
clopidogrel carboxylic acid 
CNDAC +  
cotinine N-oxide 
cuevaene A 
Cyclohex-1-enecarboxylic acid 
cyclohexa-1,5-diene-1-carboxylic acid +  
cyclosporin A metabolite M1 +  
cyclosporin A metabolite M10 
cyclosporin A metabolite M13 
cyclosporin A metabolite M16 +  
cyclosporin A metabolite M17 +  
cyclosporin A metabolite M18 +  
cyclosporin A metabolite M1A 
A cyclosporin A derivative that is cyclosporin A in which the allylic methyl group of residue 1 [(2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)oct-6-enoic acid] has been oxidised to the corresponding carboxylic acid.
cyclosporin A metabolite M1cAL 
cyclosporin A metabolite M21 +  
cyclosporin A metabolite M25 
cyclosporin A metabolite M26 
cyclosporin A metabolite M8 +  
cyclosporin A metabolite M9 
D617 
desmethyl loperamide 
desmethyldoxepin +  
desmethylnaproxen  
desmethylnaproxen sulfate 
desmethylnaproxen(1-) 
desmethylranitidine 
diclofenac beta-D-glucosiduronic acid 
didesethylflurazepam 
dihydrophaseic acid 
dioxoaminopyrine 
dodeca-2,6,10-trienoic acid +   
doxorubicinol 
enbucrilate 
enol-phenylpyruvic acid 
epi-dihydrophaseic acid 
ethisterone 
farnesoic acid +   
fenofibric acid 
fusidic acid  
gamendazole 
gaudichaudiic acid F 
gaudichaudiic acid G 
geranic acid  
glycinexylidide +  
glycosmisic acid +  
glycosmisic acid 4'-sulfate 
glycosmisic acid sulfate 
guvacine +  
hbas#3 
hepta-2,4,6-trienoic acid +  
hydroxyalbendazole 
hydroxyfenbendazole 
hygrolidin 
icas#15 
icas#17 
icas#19 
icas#21 
icas#3 
icas#7 
icos#15 
icos#17 
icos#3 
imidaprilat  
indometacin +   
ixazomib +   
kalimantacin B 
leptomycin +   
loganic acid 
maleamic acid 
mbas#3 
meropenem +   
methacrylic acid +   
mevinolinic acid 
monoethylglycinexylidide +   
myrtenic acid 
N,N-didesmethylvenlafaxine 
N,O-didesmethylvenlafaxine 
N-acetylsulfamethoxazole 
N-desmethylvenlafaxine 
N-formylmaleamic acid 
nitrazepam +   
nitrososulfadiazine 
nitrososulfapyridine 
norfentanyl 
nortriptyline  
norverapamil  
O-desethyl candesartan 
O-desmethylvenlafaxine 
octadec-2-enoic acid +  
oscr#15 +  
oscr#17 +  
oscr#19 +  
oscr#21 +  
oscr#23 +  
oscr#25 +  
oscr#27 +  
oscr#29 +  
oscr#3 +  
oscr#31 +  
oscr#33 +  
oscr#35 +  
oscr#37 +  
oscr#7 +  
oxidopamine  
oxyphenbutazone +   
paliperidone 
paracetamol sulfate +   
pent-2-enoic acid +  
penta-2,4-dienoic acid +   
pentalenolactone 
pentalenolactone D 
pentalenolactone E 
pentalenolactone F 
perillic acid +   
perindoprilat 
phaseic acid +  
phenylpropiolic acid 
prednisolone +   
procainamide 4-hydroxylamine 
proglumide +  
promazine sulfoxide 
propynoic acid +  
psilocin +  
pyrazine-2-carboxylic acid  
pyridine N-oxide +   
rac-nortilidine 
ramiprilat  
ranitidine N-oxide 
ranitidine-S-oxide 
retinoic acid +   
ritalinic acid  
S-(5-acetamido-2-hydroxyphenyl)-N-acetyl-L-cysteinate 
S-(5-acetamido-2-hydroxyphenyl)-N-acetyl-L-cysteine 
sedanonic acid 
shikimic acid +   
SN-38 +   
sorbic acid +   
spiraprilat +   
sulfadiazine hydroxylamine 
sulfapyridine hydroxylamine 
tedizolid 
tenofovir (anhydrous) +   
teriflunomide  
theophylline  
torvanol A hydrogen sulfate 
trandolaprilat 
trans-2-icosenoic acid +  
trans-2-pentadecenoic acid +  
trichostatic acid +   
triptobenzene D 
triptobenzene H 
triptoditerpenic acid B 
triptohairic acid 
triptoquinone A 
TX-1875 
unsaturated heparin disaccharide +  
uridine +   
urocanic acid +   
valanimycin 
WR-1065  
zealexin A1 
zofenoprilat 

Synonyms
Exact Synonyms: (2E,5R,6R)-6-[(2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-ethyl-11,17,26,29-tetraisobutyl-14,32-diisopropyl-1,7,10,16,20,23,25,28,31-nonamethyl-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl]-6-hydroxy-5-methylhex-2-enoic acid
Related Synonyms: AM1A ;   Formula=C62H109N11O14 ;   InChI=1S/C62H109N11O14/c1-24-42-58(83)67(17)32-47(74)68(18)43(28-33(2)3)55(80)66-49(37(10)11)61(86)69(19)44(29-34(4)5)54(79)63-40(15)53(78)64-41(16)57(82)70(20)45(30-35(6)7)59(84)71(21)46(31-36(8)9)60(85)72(22)50(38(12)13)62(87)73(23)51(56(81)65-42)52(77)39(14)26-25-27-48(75)76/h25,27,33-46,49-52,77H,24,26,28-32H2,1-23H3,(H,63,79)(H,64,78)(H,65,81)(H,66,80)(H,75,76)/b27-25+/t39-,40+,41-,42+,43+,44+,45+,46+,49+,50+,51+,52-/m1/s1 ;   InChIKey=BEDOPNJARNLRIQ-ZGBBRUJZSA-N ;   M1A ;   SMILES=[C@H]1(N(C([C@@H](N(C([C@@H](N(C)C([C@@H](N(C([C@H](NC([C@@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C)C(CN(C([C@@H](NC1=O)CC)=O)C)=O)CC(C)C)=O)C(C)C)=O)C)CC(C)C)=O)C)=O)C)=O)C)CC(C)C)=O)CC(C)C)=O)C)C(C)C)=O)C)[C@@H]([C@@H](C/C=C/C(=O)O)C)O ;   cyclosporin A metabolite AM1A ;   cyclosporin metabolite AM1A ;   cyclosporin metabolite M1A ;   cyclosporine A metabolite AM1A ;   cyclosporine A metabolite M1A ;   cyclosporine metabolite AM1A ;   cyclosporine metabolite M1A
Xrefs: PMID:1679393 "Europe PMC" ;   PMID:1804640 "Europe PMC" ;   PMID:1804641 "Europe PMC"

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.