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Term:
Parent Terms Term With Siblings Child Terms
chelator +   
dithiol +     
primary alcohol +     
(+)-(7'S,8S,8'S)-3',4-dihydroxy-2',3,4',5-tetramethoxy-6',9-epoxy-2,7'-cyclolignan-9'-ol 
(+)-(7R,7'R,7''R,7'''S,8S,8'S,8''S,8'''S)-4'',4'''-dihydroxy-3,3',3'',3''',5,5'-hexamethoxy-7,9':7',9-diepoxy-4,8'':4',8'''-bisoxy-8,8'-dineolignan-7'',7''',9'',9'''-tetraol 
(+)-(7R,7'R,7''S,7'''S,8S,8'S,8''S,8'''S)-4'',4'''-dihydroxy-3,3',3'',3''',5,5'-hexamethoxy-7,9':7',9-diepoxy-4,8'':4',8'''-bisoxy-8,8'-dineolignan-7'',7''',9'',9'''-tetraol 
(+)-(7R,7'R,8S,8'S)-4'-hydroxy-3,3',4,5,5'-pentamethoxy-7,7'-epoxylignan-9,9'-diol 
(+)-(7S,8R,8'R)-5,5'-dimethoxylariciresinol 
(+)-(7S,8S)-1',4-dihydroxy-3,3',5'-trimethoxy-7',8',9'-trinor-8,4'-oxyneolignan-7,9-diol 
(+)-(7S,8S)-4-hydroxy-3,3',5'-trimethoxy-8',9'-dinor-8,4'-oxyneolignan-7,9-diol-7'-oic acid 
(+)-copalol 
(+)-dexrazoxane +   
(+)-isolariciresinol 
(+)-lariciresinol +   
(+)-lyoniresinol +  
(+)-lyoniresinol 4,4'-bis-O-beta-D-glucopyranoside 
(+)-lyoniresinol-3-alpha-O-beta-D-glucopyranoside 
(-)-(7''R,8''S)-4'',5,7-trihydroxy-3',5'-dimethoxy-4',8''-oxyflavonolignan-7'',9''-diol 
(-)-(7''S,8''S)-4'',5,7-trihydroxy-3',3'',5'-trimethoxy-4',8''-oxyflavonolignan-7'',9''-diol 
(-)-(7''S,8''S)-4'',5,7-trihydroxy-3',5'-dimethoxy-4',8''-oxyflavonolignan-7'',9''-diol 
(-)-(7'S,8S,8'R)-4,4'-dihydroxy-3,3',5,5'-tetramethoxy-7',9-epoxylignan-9'-ol-7-one 
(-)-(7R,7'R,7''R,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5,5',5''-hexamethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 
(-)-(7R,7'R,7''R,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5,5'-pentamethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 
(-)-(7R,7'R,7''R,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5-tetramethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 
(-)-(7R,7'R,7''S,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5,5',5''-hexamethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 
(-)-(7R,7'R,7''S,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5,5'-pentamethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 
(-)-(7R,7'R,7''S,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5-tetramethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 
(-)-(7R,8S,7''S,8''R)-3,3'',5,5'-tetramethoxy-4''-hydroxy-4',7-epoxy-8',9'-dinor-4,8''-oxy-8,3'-sesquineolignan-7'',9,9''-triol-7'-al 
(-)-(7R,8S,7'E)-3,4,5,5'-tetramethoxy-4',7-epoxy-8,3'-neolign-7'-ene-9,9'-diol 
(-)-ent-copalol 
(11Z)-icos-11-en-1-ol 
(13E)-labda-7,13-dien-15-ol 
(20R)-28-hydroxylupen-30-al-3-one 
(2E)-3-(4-\{[3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-1-(sulfooxy)propan-2-yl]oxy\}-3-methoxyphenyl)prop-2-enoic acid 
(2E)-3-[4-(\{1,3-dihydroxy-1-[3-methoxy-4-(sulfooxy)phenyl]propan-2-yl\}oxy)-3-methoxyphenyl]prop-2-enoic acid 
(2E,6E,10E)-omega-hydroxyfarnesyl diphosphate 
(2R,3S)-dihydrodehydrodiconiferyl alcohol 
(2S,3R)-dihydrodehydrodiconiferyl alcohol 
(2S,3S)-2,3-dihydro-3-hydroxymethyl-2-(4-hydroxyphenyl)-5-(E)-propenylbenzofuran 
(3,4-dimethoxyphenyl)methanol +  
(3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one 
(3R,4R)-3-acyl-4-(hydroxymethyl)oxolan-2-one 
(3Z,6Z,9Z)-dodecatrienol 
(4S)-4,16-dihydroxyretinoic acid 
(6S)-6-methyloctan-1-ol 
(E)-3-decen-1-ol 
(E,E)-2-methyl-6-oxohepta-2,4-dienol 
(R)-3-phosphomevalonic acid 
(R)-5-phosphomevalonic acid 
(R)-DRF053 +  
(R)-isodihydrodehydrodiconiferyl alcohol 
(R)-tetrahydrodehydrodiconiferyl alcohol 
(S)-1-(4-bromoacetamidobenzyl)EDTA 
(S)-2-aminopropan-1-ol +  
(S)-4,5-dihydroxy-2-oxopentanal 
(S)-isodihydrodehydrodiconiferyl alcohol 
(S)-tetrahydrodehydrodiconiferyl alcohol 
(S,S,S)-nicotianamine 
(Z)-hex-3-en-1-ol +   
1,2-dehydrogeissoschizoline 
1,2-dibutyrin  
1,2-dinitroglycerol 
1,4-dithiothreitol +   
1-(3,4-dimethoxyphenyl)ethane-1,2-diol 
1-(4-\{[1,3-dihydroxy-1-(4-hydroxy-3-methoxyphenyl)propan-2-yl]oxy\}-3,5-dimethoxyphenyl)propane-1,2,3-triol 
1-[(1S,2S,4S,5R)-4-hydroxy-5-(hydroxymethyl)bicyclo[3.1.0]hexan-2-yl]thymine 
1-[(1S,3S,4R,5S)-3-hydroxy-4-(hydroxymethyl)bicyclo[3.1.0]hexan-1-yl]thymine 
1-[(2-hydroxyethoxy)methyl]-6-(phenylsulfanyl)thymine 
1-[4-carboxy-2-(3-pentylamino)phenyl]-5,5-bis(hydroxymethyl)pyrrolidin-2-one 
1-heptanol  
1-hydroxy-5-phenyl-3-pentanone 
10-deoxysarpagine 
10-undecen-1-ol 
11,20-dihydroxyferruginol +  
11,20-dihydroxysugiol 
11beta,13-dihydro-8-deoxylactucin 
11beta,13-dihydrolactucin 
11beta,13-dihydrolactucopicrin 
12-deoxyphorbol-13-(3E,5E-decadienoate) 
12-hydroxyjasmonic acid +  
12-oxo-20-hydroxyleukotriene B4 
13-hydroxy-alpha-tocopherol 
13-hydroxy-gamma-tocopherol 
15-hydroxysolavetivone 
15alpha-stemmadenine 
15beta-stemmadenine 
16-hydroxytriptolide 
16beta,17-dihydroxy-ent-kaurane-19-oic acid 
17alpha(H),21beta(H)-bishomohopanol 
17beta(H),21beta(H)-bishomohopanol 
2,2':6',2''-terpyridine 
2,2-bis(4-chlorophenyl)ethanol 
2,2-Bis(bromomethyl)propane-1,3-diol  
2,3-bis(hydroxymethyl)-7-hydroxy-6-methoxy-1-tetralone 
2,3-dihydro-3beta-methoxy withaferin A 
2,3-dihydro-3beta-O-sulfate withaferin A 
2,3-dihydrowithaferin A 
2,3-disulfanylpropane-1-sulfonic acid 
2,5-bis(2-hydroxyethylamino)-3,6-diaziridinylbenzoquinone 
2,6-dimethyl-5-hepten-1-ol 
2,6-dimethylheptan-1-ol +  
2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)hexan-2-ol +   
2-(2-hydroxy-4-methoxyphenyl)-5-(3-hydroxypropyl)benzofuran 
2-(4-hydroxy-3,5-dimethoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-7H-pyrano[2,3-g][1,4]benzodioxin-7-one 
2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-7H-pyrano[2,3-g][1,4]benzodioxin-7-one 
2-(hydroxymethyl)-4-(1-hydroxy-2-\{[6-(4-phenylbutoxy)hexyl]amino\}ethyl)phenol +  
2-(morpholin-4-yl)ethanol +  
2-(piperidin-1-yl)ethanol +  
2-butoxyethanol +   
2-butyl-1-octanol 
2-chloro-2'-hydroxytriethylamine 
2-diethylaminoethanol +   
2-ethoxyethanol +   
2-Ethyl-4-methyl-1-pentanol 
2-ethylhexan-1-ol +   
2-hydroxy-3-methoxybenzaldehyde 2-pyridylhydrazone 
2-hydroxyacetophenone 
2-hydroxyethyl hexadecanoate 
2-hydroxyethyl salicylate 
2-hydroxyethyl sulfonate 
2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone 
2-isopropyl-5-methyl-1-heptanol 
2-methylbutan-1-ol +  
2-methylpropane-1,2-diol 
2-methylthioethanol 
2-phenoxyethanol +  
2-phenylethanol +   
20-epi-isoiguesterinol 
20-hydroxy-leukotriene E4 
20-hydroxyprostaglandin A1 
20-hydroxyprostaglandin E1 
20-hydroxyprostaglandin E2 
22-deacetylyanuthone A +  
29-hydroxyfriedelan-3-one 
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  
3,4,5-trimethoxy cinnamyl alcohol 
3,4-dimethoxycinnamyl alcohol 
3,5-dimethoxy-4-hydroxybenzyl alcohol-4-O-beta-D-glucopyranoside 
3,7,11-trimethyldodecan-1-ol 
3-(acetamidomethylidene)-2-(hydroxymethyl)succinic acid 
3-(hydroxymethyl)-6-[4-(3-methylbut-2-enyloxy)benzyl]piperazine-2,5-dione 
3-Bromo-1-propanol 
3-epi-fagomine 
3-hydroxy-2-hydroxymethyl-9,10-anthraquinone 
3-hydroxymethyl-4-methyl-furan-2(5H)-one 
3-mercapto-2-mercaptomethylpropanoic acid 
3-mercaptohexanol +  
3-methylbenzyl alcohol  
3-methylpentanol 
3-O-[2,3-di-O-acetyl-alpha-L-arabinopyranosyl]-hederagenin 28-O-alpha-L-rhamnopyranosyl-(1->4)-beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranoside 
3-O-[3,4-di-O-acetyl-alpha-L-arabinopyranosyl]hederagenin 28-O-alpha-L-rhamnopyranosyl-(1->4)-beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranoside 
3-O-trans-p-coumaroyl actinidic acid 
3alpha,6alpha-epoxy-4beta,5beta,27-trihydroxy-1-oxowitha-24-enolide 
4,7-diphenyl-1,10-phenanthroline +   
4-Bromo-1-butanol 
4-chlorobutanol 
4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one 
4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one 
4-hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one 
4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one 
4-hydroxycinnamyl alcohol +  
4-methylpent-3-en-1-ol +  
4-methylpentan-1-ol 
5''-hydroxycannabidiol 
5,5'-dibromo-BAPTA 
5,5'-dimethyl-BAPTA 
5-(2-hydroxyethyl)-1,3-thiazole +  
5-(2-hydroxyethyl)-4-methylthiazole 
5-(3-hydroxypropyl)-2-(2-methoxy-4-hydroxyphenyl)benzofuran 
5-(4-hydroxybutyl)hydantoin 
5-benzyl-1-(2-hydroxyethoxymethyl)uracil  
5-benzyloxybenzylacyclouridine 
5-chloro-7-iodoquinolin-8-ol  
5-hydroxymethylfurfural  
5-hydroxymethyluracil +  
6-(3-hydroxypropyl)thymine 
6-[3]-ladderane-1-hexanol 
6-\{[(4R,5R)-4-(hydroxymethyl)thymin-5-yl]methyl\}thymine 
6-methylheptan-1-ol +  
7'-hydroxyabscisic acid 
7-demethoxyegonol 
7-deoxyloganetic alcohol 
7-hydroxycannabidiol 
8'-epi-cleomiscosin A 
9'-hydroxyabscisic acid 
9-methyldecan-1-ol 
9beta-pimara-7,15-dien-19-ol 
[3-(2,2,3-trimethylcyclopent-3-enyl)cyclohex-3-enyl]methanol 
[4-(2,2,3-trimethylcyclopent-3-enyl)cyclohex-3-enyl]methanol 
ajaconine 
alatolide 
all-trans-3,4-didehydro-13,14-dihydroretinol 
all-trans-7,8-dihydroretinol 
andrastin B +   
andrographolide  
ankorine 
aplysinoplide A 
aplysinoplide B 
aplysinoplide C 
aromatic primary alcohol +   
aryllmethyl dialkyl phosphate 
BAPTA +   
bathocuproine disulfonic acid  
benserazide  
bidenlignaside A 
biphenyl-4,4'-dithiol 
bosentan +   
buddlenol A 
buddlenol B 
buddlenol C 
butan-1-ol +   
butyn-1-ols +  
cafestol  
calcium acetate +  
calcium acetate monohydrate 
caracurine VII 
celasdin B 
cetoniacytone A 
chanoclavine-I +  
chelate-forming peptide +   
chrysanthemol +   
chrysobactin 
chrysogedone B 
cinnamyl alcohol +   
citric acid +   
cleomiscosin A 
clopenthixol +   
crotyl alcohol +   
cyclohexadienol +  
cyclooctatin +  
Cys-Ser 
cytosporic acid 
D-gluconic acid +   
D-penicillamine +   
daedalin A 
danielone 
decan-1-ol +   
decarbamoylsaxitoxin 
dehydrodiconiferyl alcohol +  
deoxylimonoic acid D-ring-lactone 
deoxynivalenol  
desferricoprogen 
desferricoprogen B 
dexrazoxane hydrochloride 
dicerandrol A 
dicerandrol B 
diethylene glycol monoethyl ether  
dihydroconiferyl alcohol +  
dihydroconiferyl alcohol glucoside 
dihydrolipoamide +   
dihydrostemphyloxin I 
dimercaprol +   
A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury.
docebenone  
dodec-10-yn-1-ol 
dodecan-1-ol +   
DOTA +  
drimenol +   
EDTA disodium salt (anhydrous) +  
EDTA disodium salt dihydrate 
EDTA methidiumpropylamide 
EDTA monocalcium salt 
EDTA monomagnesium salt 
egonol +  
entecavir (anhydrous) +  
equisetin 
ergometrine +  
ergothioneine +   
erucifoline +  
erucifoline N-oxide 
erythrodiol +  
ethanol +   
ethanolamine +   
ethanols +   
ethylene glycol bis(2-aminoethyl)tetraacetic acid  
ethylene glycol monododecyl ether 
ethylenediaminediacetic acid 
ethylenediaminetetraacetic acid  
ethylenediaminetriacetic acid 
etidronate disodium 
etidronic acid  
everolimus  
farnesol +   
ficusequilignan A 
filiforminol 
fingolimod phosphate 
FluoZin-3 
flupenthixol  
furfuryl alcohol +   
ganoderone A 
ganoderone C 
GDC-0879 
geissoschizoline 
geraniol +   
glomosporin 
Gly-His-Lys  
glycidol +   
glycolic acid +   
glycosmisic acid +  
glycosmisic acid 4'-sulfate 
guaiacylglycerol beta-coniferyl ether 
guaiacylglycerol beta-scopoletinyl ether 
guignardone N 
Helminthosporol 
hentriacontan-1-ol 
heptadecan-1-ol +  
hexaconazole  
hexadecan-1-ol +  
hexan-1-ol +   
hexane-1,6-diol +  
hydroxyacetone +  
hydroxyalbendazole 
hydroxychloroquine  
hydroxytyrosol +   
idebenone  
imidazole-4-methanol 
iminodiacetic acid +  
iminodimethanethiol 
indicanone 
indolyl alcohol +   
integrastatin A 
iron chelator +   
isoamylol +   
isobrucine 
isobrucine N-oxide 
isobutanol +   
isogeraniol +  
isopentenyl alcohol +  
isopseudostrychnine 
isoretuline 
isostrychnine 
isostrychnine N-oxide 
isotanshinone IIB 
isotaxiresinol 
jaspamide L 
kahweol  
KN-93  
kojic acid  
L-phenylalaninol +  
laccaic acid B +  
lactucin +  
lactucopicrin 
lamivudine  
laureth-5 
lavandulol +  
long chain primary alcohol +   
loprodiol 
loxtidine  
lyratol C 
marianoside A 
medronic acid 
mercaptoethanol +   
methanol +   
methyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate 
methyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate 
methyl 5-(hydroxymethyl)pyrrolidine-2-carboxylate 
methyl 5-(hydroxymethyl)pyrrolidine-3-carboxylate 
methyl tuberonate 
metronidazole +   
myriaporone 3 
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  
N,N,N',N'-tetramethylethylenediamine 
N-(2-hydroxyethyl)-beta-alanine 
N-(2-hydroxyethyl)iminodiacetic acid 
N-(hydroxymethyl)phthalimide +   
N-[(+)-12-hydroxy-7-isojasmonyl]isoleucine 
N-acetylneuraminol +  
N-acylethanolamine +   
N-benzoyl-L-phenylalaninol +  
N-butyl-N-(4-hydroxybutyl)nitrosamine +   
N-ethyl-N-(2-hydroxyethyl)nitrosamine 
N-ethyldiethanolamine 
naphthylmethanol +  
negundin B 
neocuproine  
NTA +   
octadecan-1-ol +   
octadienol +   
octan-1-ol +   
omega-hydroxy fatty acid +   
omega-hydroxymenaquinone-4 
omega-hydroxyphylloquinone 
ospemifene  
oxetanocin A +  
paeonilactinone 
pamapimod 
peloruside A 
pentadecan-1-ol 
pentaerythritol 
pentalen-13-ol 
pentan-1-ol +   
penten-1-ols +  
phytochelatin +   
platensimycin A4 methyl ester 
plaunotol  
prenderol 
primary allylic alcohol +   
primary alpha-hydroxy ketone +   
primary fatty alcohol +   
propan-1-ols +   
propane-1,3-dithiol 
propenol +   
propynol +   
prosolanapyrone II 
prostaglandin F1alpha alcohol 
protostrychnine 
pyranonigrin H 
pyranonigrin I 
pyranonigrin J 
quercetin +   
retinol +   
retuline 
riddelliine N-oxide 
rostratin D 
rotiorinol C 
sarpagine +  
scalusamide A 
sch 725432 
SCH51344 
schisanwilsonene A 
sciscllascilloside E-1 
scoparic acid A 
SD-06 
sequestrant 
Ser-Tyr 
sesterstatin 2 
sesterstatin 3 
simulanol 
sinapyl alcohol +  
sinularolide B 
sinularolide C 
sinularolide D 
sodium diphosphate 
sodium gluconate 
solanesol  
sordaricin 
stemphyloxin I +  
stemphyloxin II 
strychnogucine B 
stryvomitine 
succimer  
sulfocholine +  
syn-copalol 
syringin 
tedizolid 
terpenol +   
TETA 
tetradecan-1-ol +  
tetrahydrofurfuryl alcohol +  
tetrahydroxysqualene 
theaflavin  
TMC-86A 
TMC-86B 
TMC-89A 
TMC-89B 
TMC-96 
trans-2,3-epoxydeca-4,6,8-triyn-1-ol 
trichosetin +  
triethylene glycol +  
triptobenzene A 
triptonoterpenol 
triptoquinone B 
tuberonic acid +  
undecane-1,11-diol 
undecanol 
Unsaturated alcohol 
usaramine N-oxide 
veratrone +  
vinylamycin 
viscosalactone B 
vladinol D 
voachalotine 
withaferin A +   
withalongolide A 
withalongolide B 
withalongolide C 
withalongolide D 
withalongolide E 
withalongolide G 
yanuthone F +  
yanuthone I 
yanuthone L 
zymosterol intermediate 1a 

Synonyms
Exact Synonyms: 2,3-disulfanylpropan-1-ol
Related Synonyms: 1,2-dimercapto-3-propanol ;   1,2-dithioglycerol ;   2,3-Mercaptopropanol ;   2,3-dimercaptol-1-propanol ;   2,3-dimercaptopropanol ;   2,3-dithiopropanol ;   2,3-mercaptopropan-1-ol ;   3-hydroxy-1,2-propanedithiol ;   BAL ;   British anti-Lewisite ;   British antilewisite ;   Formula=C3H8OS2 ;   InChI=1S/C3H8OS2/c4-1-3(6)2-5/h3-6H,1-2H2 ;   InChIKey=WQABCVAJNWAXTE-UHFFFAOYSA-N ;   SMILES=OCC(S)CS ;   alpha,beta-dithioglycerol ;   dimercaprolum ;   dimercaptopropanol ;   dithioglycerine ;   dithioglycerol ;   sulfactin
Xrefs: CAS:59-52-9 "ChemIDplus" ;   CAS:59-52-9 "KEGG COMPOUND" ;   CAS:59-52-9 "NIST Chemistry WebBook" ;   DrugBank:DB06782 ;   Drug_Central:3150 "DrugCentral" ;   KEGG:C02924 ;   KEGG:D00167
Xref Mesh: MESH:D004112
Xrefs: PMID:12605205 "Europe PMC" ;   PMID:14882450 "Europe PMC" ;   PMID:21006485 "Europe PMC" ;   PMID:21803782 "Europe PMC" ;   PMID:9292286 "Europe PMC" ;   Patent:US2402665 ;   Reaxys:1732058 "Reaxys" ;   Wikipedia:Dimercaprol

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.