Ontology Browser

Term:
paroxysmal nocturnal hemoglobinuria (DOID:0060284)
Annotations: Rat: (17) Mouse: (17) Human: (18) Chinchilla: (13) Bonobo: (15) Dog: (15) Squirrel: (14)
Parent Terms Term With Siblings Child Terms
hemoglobinuria +     
hemolytic anemia +     
6-Phosphogluconolactonase Deficiency 
Adenylate Kinase Deficiency, Hemolytic Anemia due to  
Alpha-Thalassemia Myelodysplasia Syndrome  
autoimmune hemolytic anemia +   
CD59 Deficiency  
congenital hemolytic anemia +   
Distal Renal Tubular Acidosis with Hemolytic Anemia  
Elevated Adenosine Deaminase, Hemolytic Anemia Due To 
Gamma-Glutamylcysteine Synthetase Deficiency, Hemolytic Anemia due to  
Glutathione Peroxidase Deficiency, Hemolytic Anemia possibly due to  
Glutathione Reductase, Hemolytic Anemia due to Deficiency of, in Red Cells  
Glutathione Synthetase Deficiency of Erythrocytes, Hemolytic Anemia due to  
Heme Oxygenase 1 Deficiency  
hemoglobinuria +   
Hemolytic Anemia with Thermal Sensitivity of Red Cells 
HEMOLYTIC ANEMIA, CONGENITAL, X-LINKED  
Hemolytic Poikilocytic Anemia due to Reduced Ankyrin Binding Sites 
hemolytic-uremic syndrome +   
Hexokinase Deficiency Hemolytic Anemia 
Monosomy 7 of Bone Marrow 
Myelodysplasia, Immunodeficiency, Facial Dysmorphism, Short Stature, and Psychomotor Delay 
Nonspherocytic Hemolytic Anemia, due to Hexokinase Deficiency  
Paroxysmal Exertion-Induced Dyskinesia and Hemolytic Anemia 
paroxysmal nocturnal hemoglobinuria +   
A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.
Primary Lymphedema with Myelodysplasia  
Refractory Anemia +   
Rh deficiency syndrome  
sideroblastic anemia +   

Synonyms
Exact Synonyms: Cold Paroxysmal Hemoglobinuria ;   Hemoglobinuria, Paroxysmal ;   Marchiafava Micheli Syndrome ;   PAROXYSMAL NOCTURNAL HEMOGLOBINURIA 1 ;   PNH1
Related Synonyms: ECULIZUMAB, POOR RESPONSE TO
Primary IDs: MESH:D006457
Alternate IDs: OMIM:300818 ;   OMIM:615749 ;   RDO:0002195
Xrefs: GARD:7337 ;   OMIM:PS300818 ;   ORDO:447
Definition Sources: MESH:D006457, https://en.wikipedia.org/wiki/Paroxysmal_nocturnal_hemoglobinuria

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