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Experimental Autoimmune Encephalomyelitis (DOID:9002763)
Annotations: Rat: (212) Mouse: (145) Human: (145) Chinchilla: (128) Bonobo: (141) Dog: (139) Squirrel: (131)
Parent Terms Term With Siblings Child Terms
acute disseminated encephalomyelitis +   
acute hemorrhagic leukoencephalitis 
Alpers syndrome +   
Balo concentric sclerosis 
chronic fatigue syndrome  
Equine Encephalomyelitis +  
Experimental Autoimmune Encephalomyelitis +   
An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)
Experimental Autoimmune Myasthenia Gravis  
Experimental Autoimmune Neuritis  
multiple sclerosis +   
neuromyelitis optica  
Progressive Encephalomyelitis with Rigidity 
Transverse Myelitis +   

Exact Synonyms: Allergic Encephalomyelitis ;   EAE ;   Experimental Allergic Encephalomyelitides ;   Experimental Allergic Encephalomyelitis
Primary IDs: MESH:D004681
Alternate IDs: RDO:0005474
Definition Sources: MESH:D004681

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.