Ontology Browser

Term:
Experimental Autoimmune Myasthenia Gravis (DOID:9008286)
Annotations: Rat: (17) Mouse: (15) Human: (15) Chinchilla: (13) Bonobo: (15) Dog: (13) Squirrel: (15)
Parent Terms Term With Siblings Child Terms
congenital myasthenic syndrome 6  
Experimental Autoimmune Encephalomyelitis +   
Experimental Autoimmune Myasthenia Gravis  
Any autoimmune animal disease model used in the study of MYASTHENIA GRAVIS. Injection with purified neuromuscular junction acetylcholine receptor (AChR) (see RECEPTORS, CHOLINERGIC) components results in a myasthenic syndrome that has acute and chronic phases. The motor endplate pathology, loss of acetylcholine receptors, presence of circulating anti-AChR antibodies, and electrophysiologic changes make this condition virtually identical to human myasthenia gravis. Passive transfer of AChR antibodies or lymphocytes from afflicted animals to normals induces passive transfer experimental autoimmune myasthenia gravis. (From Joynt, Clinical Neurology, 1997, Ch 54, p3)
Experimental Autoimmune Neuritis  
Limb-Girdle Myasthenia, Autoimmune 
Myasthenia Gravis with Thymus Hyperplasia 
neonatal myasthenia gravis 

Synonyms
Exact Synonyms: EAMG ;   Experimental Myasthenia ;   Experimental Myasthenia Gravis ;   Experimental Myasthenias ;   Passive Transfer Experimental Autoimmune Myasthenia Gravis
Primary IDs: MESH:D020720
Alternate IDs: RDO:0007422
Definition Sources: MESH:D020720

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.