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Ontology Browser

Term:
Parent Terms Term With Siblings Child Terms
cytoplasmic pattern recognition receptor signaling pathway +   
endosomal signal transduction 
hippo signaling +   
I-kappaB kinase/NF-kappaB signaling +   
inositol lipid-mediated signaling +   
intracellular signal transduction involved in positive regulation of cell growth 
intrinsic apoptotic signaling pathway +   
MAPK cascade +   
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
negative regulation of intracellular signal transduction +   
NIK/NF-kappaB signaling +   
phosphorelay signal transduction system +   
PKR signal transduction 
positive regulation of intracellular signal transduction +   
protein kinase A signaling +   
protein kinase B signaling +   
protein kinase C signaling +   
protein kinase D signaling +   
RAM/MOR signaling pathway 
regulation of intracellular signal transduction +   
second-messenger-mediated signaling +   
signal transduction by cis-phosphorylation 
signal transduction by p53 class mediator +   
signal transduction by trans-phosphorylation  
signal transduction downstream of smoothened +   
signal transduction in response to DNA damage +   
signal transduction involved in cell cycle checkpoint +   
signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle 
small GTPase mediated signal transduction +   
stress-activated protein kinase signaling cascade +   
TOR signaling +   
TRAF-mediated signal transduction 

Synonyms
Exact Synonyms: MAP kinase cascade ;   MAP kinase kinase kinase cascade ;   MAPK signal transduction ;   MAPKKK cascade ;   mitogen-activated protein kinase cascade
Narrow Synonyms: ERK/MAPK cascade ;   MAPKKK cascade during sporulation
Related Synonyms: MAPK signaling ;   MAPK signalling
Xrefs: MIPS_funcat:30.01.05.01.03 ;   Wikipedia:MAPK_cascade ;   Wikipedia:Mitogen-activated_protein_kinase
Only In Taxon: NCBITaxon:2759 ! Eukaryota
Definition Sources: GOC:bf, GOC:mtg_signaling_feb11, PMID:20811974, PMID:9561267

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.