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Ontology Browser

Term:
Hrd1p ubiquitin ligase complex (GO:0000836)
Annotations: Rat: (8) Mouse: (7) Human: (9) Chinchilla: (9) Bonobo: (9) Dog: (8) Squirrel: (9) Pig: (8)
Parent Terms Term With Siblings Child Terms
CUE1-UBC7 ubiquitin-conjugating enzyme complex 
Doa10p ubiquitin ligase complex 
Hrd1p ubiquitin ligase complex +   
A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. In mammals, this complex contains the ubiquitin ligase HRD1 (Synoviolin) or AMFR (gp78).

Synonyms
Related Synonyms: HRD1 ubiquitin ligase complex
Definition Sources: GOC:bf, GOC:elh, PMID:16619026, PMID:16873066, PMID:21454652

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.