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Ontology Browser

Term:
desensitization of G protein-coupled receptor signaling pathway by arrestin (GO:0002032)
Annotations: Rat: (3) Mouse: (3) Human: (3) Chinchilla: (3) Bonobo: (3) Dog: (3) Squirrel: (3) Pig: (3)
Parent Terms Term With Siblings Child Terms
desensitization of G protein-coupled receptor signaling pathway by arrestin  
The process that inhibits the signaling function of a G protein-coupled receptor by uncoupling the receptor from its downstream G proteins.
G protein-coupled receptor internalization +   
inhibitory G protein-coupled receptor phosphorylation +   
negative regulation of actin binding +   
negative regulation of apolipoprotein binding  
negative regulation of C-C chemokine binding  
negative regulation of guanyl-nucleotide exchange factor activity +   
negative regulation of heparan sulfate proteoglycan binding 
negative regulation of microtubule binding +   
negative regulation of protein homodimerization activity  
negative regulation of Ras GTPase binding +   
negative regulation of receptor binding +   

Synonyms
Exact Synonyms: arrestin mediated desensitisation of G-protein coupled receptor protein signalling pathway ;   arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway ;   desensitization of G-protein coupled receptor protein signaling pathway by arrestin
Definition Sources: GOC:dph, GOC:tb, PMID:8396717

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.