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marginal zone B cell differentiation (GO:0002315)
Annotations: Rat: (9) Mouse: (10) Human: (9) Chinchilla: (9) Bonobo: (9) Dog: (9) Squirrel: (9) Pig: (9)
Parent Terms Term With Siblings Child Terms
follicular B cell differentiation  
germinal center B cell differentiation  
marginal zone B cell differentiation  
The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL).
memory B cell differentiation  
plasma cell differentiation +   

Exact Synonyms: marginal zone B lymphocyte differentiation
Related Synonyms: marginal zone B cell development
Definition Sources: GOC:jal, ISBN:0781735149

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.