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Term:
Factor XII activation (GO:0002542)
Annotations: Rat: (2) Mouse: (1) Human: (2) Chinchilla: (2) Bonobo: (2) Dog: (0) Squirrel: (0) Pig: (1)
Parent Terms Term With Siblings Child Terms
Factor XII activation  
Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade.
negative regulation of plasma kallikrein-kinin cascade 
positive regulation of acute inflammatory response to antigenic stimulus +   
positive regulation of acute inflammatory response to non-antigenic stimulus  
positive regulation of fever generation +   
positive regulation of kinin cascade +  
positive regulation of peptide hormone processing 
positive regulation of plasma kallikrein-kinin cascade 
positive regulation of plasminogen activation  
positive regulation of protein processing in phagocytic vesicle  
positive regulation of sterol regulatory element binding protein cleavage 
regulation of plasma kallikrein-kinin cascade +  

Synonyms
Exact Synonyms: Hageman factor activation
Definition Sources: GOC:jal, ISBN:0721601871

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.