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Ontology Browser

transcription coactivator activity (GO:0003713)
Annotations: Rat: (268) Mouse: (260) Human: (347) Chinchilla: (322) Bonobo: (324) Dog: (181) Squirrel: (12) Pig: (199)
Parent Terms Term With Siblings Child Terms
transcription coactivator activity +   
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
transcription corepressor activity +   

Exact Synonyms: transcription co-activator activity
Related Synonyms: RNA polymerase II transcription co-activator activity ;   RNA polymerase II transcription coactivator activity ;   RNA polymerase II transcription mediator activity
Alternate IDs: GO:0001105
Definition Sources: GOC:txnOH-2018, PMID:10213677, PMID:16858867

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.